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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Open Fracture Wounds Clear all
Terminated Not applicable Interventional Results available

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

NCT01430182
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2016 · Synced Jul 22, 2026, 1:25 PM EDT
Recruiting No phase listed Observational

Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care

NCT04299022
View directory record Official record
Conditions
Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited, Fracture, Tibial, Fracture of Femur, Fracture Arm
Interventions
Vivigen Cellular Bone Matrix
Other
Lead sponsor
LifeNet Health
Industry
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Orlando, Florida • Jersey City, New Jersey • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Jul 22, 2026, 1:25 PM EDT
Terminated Phase 4 Interventional

Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens

NCT03560232
View directory record Official record
Conditions
Open Fracture, Post-Op Wound Infection
Interventions
Ceftriaxone, Ampicillin/sulbactam, Piperacillin/tazobactam, Cefazolin + Gentamicin, Clindamycin + Gentamicin
Drug
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Warren, Ohio • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Jul 22, 2026, 1:25 PM EDT
Withdrawn Phase 4 Interventional

Duloxetine Tibial Plateau

NCT04639011
View directory record Official record
Conditions
Tibial Plateau Fracture, Pain, Postoperative
Interventions
Duloxetine, Placebo, Standard of care (SOC) for tibial plateau surgery
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Jul 22, 2026, 1:25 PM EDT
Recruiting Not applicable Interventional

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

NCT05792189
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture, Koos Jr assesment on subjects with DFR of distal femur fracture
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 22, 2026, 1:25 PM EDT
Withdrawn Phase 2 Interventional

Efficacy of Tranexamic Acid (TXA) in Humerus ORIF

NCT05802238
View directory record Official record
Conditions
Fracture Humerus
Interventions
Tranexamic acid (TXA), Saline
Drug · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jul 22, 2026, 1:25 PM EDT
Recruiting Not applicable Interventional

Accelerated Flap Coverage in Severe Lower Extremity Trauma

NCT06293469
View directory record Official record
Conditions
Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
Interventions
Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
356 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
7
States / cities
Sacramento, California • Baltimore, Maryland • Largo, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 22, 2026, 1:25 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Retrospective Analysis on Distal Humerus Fractures

NCT03637621
View directory record Official record
Conditions
Distal Humerus Fracture
Interventions
ORIF
Other
Lead sponsor
The Orthopaedic Research & Innovation Foundation
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Edgewood, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Jul 22, 2026, 1:25 PM EDT
Completed Phase 3 Interventional Results available

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

NCT02480621
View directory record Official record
Conditions
Ankle Fracture
Interventions
Liposomal Bupivacaine with Bupivacaine
Drug
Lead sponsor
Jamaica Hospital Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Jul 22, 2026, 1:25 PM EDT
Completed No phase listed Observational

Percutaneous Screw Fixation vs. Open Fixation in the Treatment of Thoracolumbar Fractures

NCT04495400
View directory record Official record
Conditions
Lumbar Vertebral Fracture
Interventions
Thoracolumbar Fracture Fixation
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Not listed
Enrollment
485 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Jul 22, 2026, 1:25 PM EDT
Recruiting Phase 4 Interventional

Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

NCT06113211
View directory record Official record
Conditions
Opioid Use, Fractures, Bone, Trauma
Interventions
Narcotic pain medication, Nonnarcotic pain medications
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 22, 2026, 1:25 PM EDT
Not listed No phase listed Observational

Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds

NCT03872544
View directory record Official record
Conditions
Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection, Wound Complication, Wound Dehiscence, Wound of Skin, Wound Open, Wounds, Penetrating, Wounds, Nonpenetrating, Wounds and Injuries, Wounds, Disturbance of Wound Healing, Facial Bones Fracture, Soft Tissue Injuries, Skull Fractures, Surgical Wound, Surgical Wound Infection, Wound Healing
Interventions
Not listed
Lead sponsor
Dufresne, Craig, MD, PC
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Jul 22, 2026, 1:25 PM EDT
Recruiting No phase listed Observational

OCT in Open Fracture and Infected Fracture

NCT05785182
View directory record Official record
Conditions
Trauma Injury, Trauma, Open Fracture, Fracture Infection
Interventions
Open Fracture, Infected Fracture
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Jul 22, 2026, 1:25 PM EDT
Not listed No phase listed Observational

Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds

NCT03880188
View directory record Official record
Conditions
Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries, Skull Fractures, Surgical Wound, Surgical Wound Infection, Wound Healing, Disturbance of Wound Healing, Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Complication, Wound Dehiscence, Wound of Skin, Wound Open, Wounds, Penetrating, Wounds, Nonpenetrating, Wounds
Interventions
Not listed
Lead sponsor
Dufresne, Craig, MD, PC
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Jul 22, 2026, 1:25 PM EDT
Terminated Not applicable Interventional Results available

Single Shot vs Catheter Infraclavicular Brachial Plexus Block After Distal Radius Fracture Repair

NCT02744352
View directory record Official record
Conditions
Distal Radius Fracture, Post Operative Pain Control
Interventions
20ml bolus of 0.5% ropivicaine, 0.2% of ropivacaine at 8 milliliter/hour
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Jul 22, 2026, 1:25 PM EDT
Withdrawn Not applicable Interventional

Arthroscopic Assisted Open Reduction Internal Fixation Versus Open Reduction Internal Fixation in Ankle Fractures

NCT03084263
View directory record Official record
Conditions
Ankle Fractures
Interventions
Arthroscopic Assisted Open Reduction Internal Fixation, Open Reduction Internal Fixation
Procedure
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Jul 22, 2026, 1:25 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Proximal Humerus Fractures: A Retrospective Analysis

NCT03637608
View directory record Official record
Conditions
Proximal Humeral Fracture
Interventions
Not listed
Lead sponsor
The Orthopaedic Research & Innovation Foundation
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Edgewood, Kentucky
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Jul 22, 2026, 1:25 PM EDT
Recruiting Not applicable Interventional

The Treatment of Type I Open Fractures in Pediatrics

NCT00870064
View directory record Official record
Conditions
Fractures, Open
Interventions
Formal Operative Treatment, Emergency Department Treatment
Procedure
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
3 Years to 14 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 22, 2026, 1:25 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Application of Indocyanine Green Angiography for Closed Operative Calcaneus Fractures

NCT01693484
View directory record Official record
Conditions
Fractures, Comminuted, Surgical Wound Dehiscence, Necrosis
Interventions
ICG (Indocyanine Green)
Drug
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Jun 19, 2017 · Synced Jul 22, 2026, 1:25 PM EDT
Completed Phase 4 Interventional

Efficacy of DBM on Fractures of the Shinbone (Tibia)

NCT00299052
View directory record Official record
Conditions
Closed Fracture, Open Fracture
Interventions
Grafton DBM, Reamings
Device · Biological
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced Jul 22, 2026, 1:25 PM EDT
Completed Phase 2 Interventional

Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta

NCT01417091
View directory record Official record
Conditions
Osteogenesis Imperfecta
Interventions
BPS804
Drug
Lead sponsor
Ultragenyx Pharmaceutical Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Anaheim, California • Miramar, Florida
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Jul 22, 2026, 1:25 PM EDT
Not listed Not applicable Interventional

Intramedullary Bone Grafting for Open Tibial Shaft Fractures

NCT03891888
View directory record Official record
Conditions
Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
Interventions
Intramedullary Bone Graft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jul 22, 2026, 1:25 PM EDT
Not listed Not applicable Interventional

Sinus Tarsi Versus Extensile Lateral Approach for Calcaneus Fractures

NCT02446470
View directory record Official record
Conditions
Intra-articular Fractures
Interventions
Sinus Tarsi approach, Extensile Lateral approach
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Jul 22, 2026, 1:25 PM EDT
Completed Phase 3 Interventional Results available

Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption

NCT03710889
View directory record Official record
Conditions
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis Vertebral, Osteoporosis Risk, Osteoporosis Fracture, Osteoporosis Localized to Spine, Osteoporosis, Age-Related, Osteoporosis Senile, Osteoporosis of Vertebrae
Interventions
Abaloparatide
Drug
Lead sponsor
Radius Health, Inc.
Industry
Eligibility
50 Years to 85 Years · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
Golden, Colorado • Gainesville, Georgia • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Jul 22, 2026, 1:25 PM EDT