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ClinicalTrials.gov public records Last synced Oct 4, 2026, 11:54 AM EDT

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Showing 25–48 of 72 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Opioid Medication Assisted Treatment Clear all
Completed Not applicable Interventional Results available

Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes

NCT04433975
View directory record Official record
Conditions
Opioid-use Disorder, Medication Assisted Treatment, Chronic Pain
Interventions
Psychosocial Pain Management (PPMI), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Oct 4, 2026, 11:54 AM EDT
Active, not recruiting Not applicable Interventional

Supporting Treatment Access and Recovery Through Linkage and Support

NCT05713695
View directory record Official record
Conditions
Mental Health Disorders, Substance Use Disorders
Interventions
Full MISSION, Linkage Only Delivered by a Peer Specialist
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

By Potentially Adding a Century Old Therapeutic Measure to Pain Treatment Regimens Called Osteopathic Manipulative Treatment, Can Help Decrease Muscle and Bone Pain and the Usage of Opioid Pain Medication.

NCT06930196
View directory record Official record
Conditions
Osteopathic Manipulative Treatment
Interventions
Counterstrain, Muscle Energy, High Velocity Low Amplitude, The Ultralign SA201 used for measuring tissue texture changes, IsoTouch
Other · Device
Lead sponsor
Skagit Regional Health
Other
Eligibility
18 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional

Examining an Adaptive Approach to Providing Psychosocial Support to Buprenorphine Patients

NCT04650386
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Psychosocial support determined by adaptive treatment algorithm
Behavioral
Lead sponsor
Public Health Management Corporation
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 6, 2024 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery

NCT00877799
View directory record Official record
Conditions
Acute Pain
Interventions
CR845, Placebo
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
21 Years to 60 Years · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
12
States / cities
Mobile, Alabama • Sheffield, Alabama • Phoenix, Arizona + 7 more
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Oct 4, 2026, 11:54 AM EDT
Completed No phase listed Observational

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study

NCT03911739
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opiate Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
Not listed
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
10
States / cities
Jacksonville, Florida • Boston, Massachusetts • Portland, Oregon + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Active, not recruiting Not applicable Interventional

Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder

NCT04257214
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Psychosocial treatment
Behavioral
Lead sponsor
Philadelphia College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
5
States / cities
Atlantic City, New Jersey • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 4, 2026, 11:54 AM EDT
Recruiting Not applicable Interventional

Evaluating a Culinary Curriculum Program for Residents of Medication Assisted Therapy (MAT) Recovery Houses

NCT07251205
View directory record Official record
Conditions
Cooking Skills
Interventions
Culinary curriculum
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 4, 2026, 11:54 AM EDT
Active, not recruiting Not applicable Interventional

Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

NCT05733442
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Treatment as usual (TAU), CHaRRM-CN
Other
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Tahlequah, Oklahoma • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder

NCT04664062
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Dependence
Interventions
Medication Assisted Treatment
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
16 Years to 89 Years
Enrollment
303 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
2
States / cities
Denver, Colorado • Leawood, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional Results available

Usability Testing for the Reward-based Technology to Improve OUD Treatment

NCT05159362
View directory record Official record
Conditions
Opioid-use Disorder, Contingency Management, Medication for Opioid-use Disorder
Interventions
Software Application
Other
Lead sponsor
Q2i, LLC
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Oct 4, 2026, 11:54 AM EDT
Completed No phase listed Observational

Medications for Opioid Use Disorders (MOUD) Via Telemedicine

NCT03566459
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
CBOC offering Tele-MOUD to Veterans, CBOC not offering Tele-MOUD to Veterans
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
West Haven, Connecticut • Augusta, Maine
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Oct 4, 2026, 11:54 AM EDT
Completed No phase listed Observational

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study

NCT03911466
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
12
States / cities
Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional

Recovery Initiation and Management After Overdose (RIMO) Experiment

NCT03895827
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Recovery Initiation and Management after Overdose (RIMO), Passive Referral to Treatment Control
Behavioral · Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional Results available

Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment

NCT04178551
View directory record Official record
Conditions
Opioid Medication Assisted Treatment
Interventions
Implementation Facilitation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
11
States / cities
Birmingham, Alabama • West Los Angeles, California • Aurora, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Phase 4 Interventional Results available

Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings

NCT02978417
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Naltrexone for extended-release injectable suspension, Oral naltrexone
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Phase 1 Interventional

Medication-Assisted Treatment for Youth With Substance Use Disorders

NCT02593474
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Dependence
Interventions
Naltrexone
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
16 Years to 25 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Oct 4, 2026, 11:54 AM EDT
Terminated Not applicable Interventional Results available

Reward-based Technology to Improve OUD Treatment

NCT05180669
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
OARSCM Software Application, MyMAT Software Application
Other
Lead sponsor
Q2i, LLC
Industry
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Phase 3 Interventional Results available

Medication Treatment for Opioid Use Disorder in Expectant Mothers

NCT03918850
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional Results available

Start Treatment and Recovery for Opioid Use Disorder

NCT04505540
View directory record Official record
Conditions
Opioid-use Disorder, Mental Disorder, Opioid Medication Assisted Treatment
Interventions
Bridge Clinic
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Oct 4, 2026, 11:54 AM EDT
Recruiting Not applicable Interventional

Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

NCT06732596
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Embodied conversational agent (ECA), Technical support, Additional ECA messages, Additional incentives
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact on Opioid Use of Bundling Medication-assisted Treatment With mHealth

NCT02712034
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
MAT + A-CHESS, MAT
Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional

Pilot Test of Patient Decision Aid for Opioid Use Disorder

NCT03394261
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Patient Decision Aid
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Tarzana, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Oct 4, 2026, 11:54 AM EDT
Completed Not applicable Interventional Results available

reSET-O RCT (Randomized Controlled Trial)

NCT04129580
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
reSET-O app
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Harrisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Oct 4, 2026, 11:54 AM EDT