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Showing 1–24 of 170 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Completed Not applicable Interventional Results available

THRIVE: Culturally AdapTed Harm Reduction Intervention

NCT06609278
Conditions
Opioid Use, Stimulant Use
Interventions
harm reduction intervention
Behavioral
Lead sponsor
Brittany Miller-Roenigk
Other
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
3
States / cities
Louisville, Kentucky • Cincinnati, Ohio
Conditions
Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
Interventions
More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
805 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana • Seattle, Washington
Completed No phase listed Observational

Development of a Tracheal Sound Sensor

NCT05506267
Conditions
Respiratory Insufficiency, Opioid Overdose, Hypoventilation
Interventions
Trachea Sound Sensor (TSS)
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Active, not recruiting Not applicable Interventional

Mobile Peer Support for OUD Recovery

NCT05405712
Conditions
Opioid Use Disorder
Interventions
Mobile Phone App
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
1,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Indianapolis, Indiana • Providence, Rhode Island
Conditions
Arthropathy of Knee, Post Operative Pain, Opioid Use, Opioid Abuse, Opioid Misuse
Interventions
Opioid education in person, Opioid education via video
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Conditions
Opiate Addiction
Interventions
Onsite treatment, Enhanced referral, Buprenorphine
Behavioral · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
3
States / cities
New York, New York • The Bronx, New York
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids

NCT05503186
Conditions
Opioid Misuse
Interventions
Text Message, Standard of Care
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Conditions
Opioid Overdose
Interventions
Extensive training
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
New York, New York
Conditions
Opioid Misuse
Interventions
CPMRx
Behavioral
Lead sponsor
Jessica Morgan
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficiency And Quality In Post-Surgical Pain Therapy After Discharge

NCT05221866
Conditions
Opioid Use, Opioid Dependence, Opioid Misuse, Post-Surgical Complication
Interventions
Empowering Patient to Steer Their Pain Management After Surgery, Provider-facing Prescription Aid
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 89 Years
Enrollment
711 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Omaha, Nebraska
Completed Not applicable Interventional Accepts healthy volunteers

E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs

NCT06443385
Conditions
Opioid Prescribing, Prescription Drug Misuse
Interventions
PDMP Legal Mandate E-mail, PDMP Clinical Benefit E-mail
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
7,872 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Recruiting No phase listed Observational Accepts healthy volunteers

Emergency Medicine Peer Outreach Worker Engagement for Recovery

NCT06320015
Conditions
Substance Use Disorders, Overdose, Opioid Use Disorder, Alcohol Use Disorder
Interventions
Substance Misuse Assistance Response Team (SMART), Usual Care Group
Behavioral · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Overdose, Risk Behavior
Interventions
Naloxone Navigator (NN)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,004 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Denver, Colorado
Conditions
Accidental Overdose of Opiate
Interventions
Take home rapid drug test
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 35 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Providence, Rhode Island
Completed Not applicable Interventional Accepts healthy volunteers Results available

Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder

NCT02669901
Conditions
Opiate Antagonist Overdose, Opioid-Related Disorders
Interventions
Naloxone Auto-Injector
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
395 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Albuquerque, New Mexico
Conditions
Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse, Substance Abuse, Opioid Use, Unspecified, Opioid Dependence, Drug Overdose
Interventions
TTIP-PRO
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Cincinnati, Ohio
Conditions
Pain, Acute, Opioid Misuse, Obstetric Pain, Cesarean Section Complications
Interventions
Deterra activated charcoal pouch
Other
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Danville, Pennsylvania
Suspended Phase 2 Interventional Accepts healthy volunteers

Reducing Opioid Use and Misuse After Wisdom Molar Extractions

NCT04414917
Conditions
Pain, Postoperative
Interventions
Twin block, iPill dispenser
Drug · Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
New Brunswick, New Jersey
Conditions
Opioid Overdose
Interventions
Observation only
Other
Lead sponsor
Member Companies of the Opioid PMR Consortium
Industry
Eligibility
18 Years to 79 Years
Enrollment
808,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
4
States / cities
Wilmington, Delaware • Boston, Massachusetts • Portland, Oregon + 1 more
Conditions
Opioid Overdose
Interventions
Enhanced Overdose Education (EOE), Standard education
Behavioral
Lead sponsor
Hartford Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Hartford, Connecticut
Conditions
Opioid Misuse, Older Adults, HIV
Interventions
Choacot: Behavioral Intervention for Chronic Opioid Use, Health Education
Behavioral · Other
Lead sponsor
Butler Hospital
Other
Eligibility
50 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Drug Prescriptions
Interventions
Disposal pouch
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
313 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Not listed No phase listed Observational

Overdose Risk Management and Naloxone

NCT03933345
Conditions
Opioid Use
Interventions
Study provides naloxone to participants who wish to have it. Not required to accept naloxone and no control.
Other
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
18 Years and older
Enrollment
600 participants
Timeline
2019 – 2023
U.S. locations
2
States / cities
New York, New York
Conditions
Opiate Abuse, Opiate Overdose, Opioid-use Disorder
Interventions
Peer Addiction Counseling
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Greenville, South Carolina