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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:08 PM EDT

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Showing 49–72 of 79 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Opioid Prescribing Clear all
Completed Not applicable Interventional Accepts healthy volunteers

An Opioid Prescribing Nudge

NCT04069403
View directory record Official record
Conditions
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior, Benzodiazepine Abuse, Benzodiazepine Dependent
Interventions
Automated Reports on prescription patterns for their patients
Other
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
427 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Impact of OMT on Physician Pain

NCT05488158
View directory record Official record
Conditions
Pain
Interventions
Osteopathic manipulation
Other
Lead sponsor
Fort Wayne Medical Education Program
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy

NCT05182606
View directory record Official record
Conditions
Opioid Misuse, Chronic Pain
Interventions
Pilot study of algorithms implementation package
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 20, 2026, 11:08 PM EDT
Completed No phase listed Observational

Toward Safer Opioid Prescribing for Chronic Pain in High Risk Populations

NCT03669939
View directory record Official record
Conditions
HIV Disease, Chronic Pain
Interventions
Communication Strategy, Standard of Care
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2020 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nudging Providers to Curtail Dangerous Opioid Prescribing: A Trial to Investigate Mechanisms

NCT04628832
View directory record Official record
Conditions
Opioid Use
Interventions
PMP Use Mandate Letter, Prescribing Information Letter, Prescribing Information + PMP Use Mandate Letter
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
12,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 19, 2022 · Synced Oct 20, 2026, 11:08 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Reducing Concurrent Opioid-Benzodiazepine Prescriptions

NCT03887247
View directory record Official record
Conditions
Adverse Drug Effect of Opioids, Adverse Drug Effect of Benzodiazepines
Interventions
E-mail Alert
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older
Enrollment
2,234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Chronic Pain OneSheet Clinical Trial

NCT04295135
View directory record Official record
Conditions
Chronic Pain
Interventions
Chronic Pain OneSheet
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Indianapolis, Indiana • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 24, 2024 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating Interventions to Reduce Residual Opioids in the Home Following Legitimate Opioid Prescribing in Children.

NCT04219397
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Medication take back, Medication home disposal
Other
Lead sponsor
Indiana University
Other
Eligibility
12 Years to 18 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Indianapolis, Indiana • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 20, 2026, 11:08 PM EDT
Not yet recruiting Not applicable Interventional

Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support

NCT07073924
View directory record Official record
Conditions
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Interventions
Implementation strategy bundle
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
536 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

De-prescribing Program to Evaluate Falls in Older Adults

NCT04272671
View directory record Official record
Conditions
Opioid-Related Disorders, Benzodiazepine-Related Disorders, Falls Injury
Interventions
Educational Intervention
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
65 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 5, 2022 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Postoperative Nudges to Reduce Opioid Prescribing

NCT05070338
View directory record Official record
Conditions
Opioid Prescribing
Interventions
Guideline-Based (Injunctive Norm) Nudges, Peer-Based (Social Norm) Nudges
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Opioid-Naive Population

NCT04601493
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Use, Opioid Abuse
Interventions
Choice Architecture Nudge, PMP Integration & Nudge
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
Not listed
Enrollment
631 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Oct 20, 2026, 11:08 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery

NCT06532708
View directory record Official record
Conditions
Opioid Use, Postoperative Pain
Interventions
5x Oxycodone Oral Tablets, 16x Oxycodone Oral Tablets
Other
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 2, 2024 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Prescribing Vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients with Postoperative Pain:

NCT05370404
View directory record Official record
Conditions
Acute Pain, Surgery
Interventions
Prescription by surgical team, Recommendation by surgical team
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Peer Comparison Feedback on Opioid Prescribing

NCT03183882
View directory record Official record
Conditions
Opioid Use
Interventions
Personal Feedback, Peer Normative Comparison Feedback
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 99 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2017 · Synced Oct 20, 2026, 11:08 PM EDT
Completed No phase listed Observational

A Naturalistic Experiment Evaluating the Impact of Medicaid Treatment Reimbursement Changes on Opioid Prescribing and Patient Outcomes Among Patients With Back Pain

NCT03393143
View directory record Official record
Conditions
Back Pain, Neck Pain
Interventions
Not listed
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 65 Years
Enrollment
2,748 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Behavioral Insights to Encourage Judicious Prescribing of Opioids

NCT02790476
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Letters
Other
Lead sponsor
University of Southern California
Other
Eligibility
Not listed
Enrollment
851 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Oct 20, 2026, 11:08 PM EDT
Completed No phase listed Observational

Self Reported Deviations From Opioid Analgesic Prescription

NCT00907192
View directory record Official record
Conditions
Advanced Cancers
Interventions
Personal Interview, Questionnaire
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 1: EHR Nudges

NCT04477304
View directory record Official record
Conditions
Opioid Abuse, Unspecified
Interventions
Opioid Naive, OR, At-risk for long-term use, OR, Long-term opioid recipient
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
555 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Oct 20, 2026, 11:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Decision Support to Improve System Naloxone Co-prescribing

NCT06271668
View directory record Official record
Conditions
Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
Interventions
Naloxone Co-prescribing Clinical Decision Support (CDS)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 89 Years
Enrollment
114,272 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Strategies to Improve Pain and Enjoy Life

NCT03743402
View directory record Official record
Conditions
Chronic Pain
Interventions
Pain self-management training, video education, motivational interviewing, voluntary self-paced opioid taper, prescribing guidance for primary care provider, usual care
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2023 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Prescribing Opioid Pain Relievers in the Emergency Department: Understanding and Optimizing the Encounter

NCT02299024
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Additional Opioid Information
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Testing a Provider-Level Feedback Intervention to Optimize Postoperative Prescribing

NCT04776928
View directory record Official record
Conditions
Opioid Prescribing
Interventions
Push reports
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Oct 20, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

A Clinician-Focused Nudging Intervention to Optimize Post-Surgical Prescribing

NCT05299528
View directory record Official record
Conditions
Opioid Prescribing, Surgical Procedure, Unspecified
Interventions
Direct Feedback
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
465 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 20, 2026, 11:08 PM EDT