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ClinicalTrials.gov public records Last synced Oct 25, 2026, 5:42 AM EDT

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Showing 937–960 of 1,479 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Opioid Related Disorders Clear all
Completed Not applicable Interventional Results available

SMART Effectiveness Trial

NCT04464421
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Dependence, Treatment Adherence
Interventions
Contingency Management (CM), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM)
Behavioral
Lead sponsor
Karen Derefinko, PhD
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder

NCT04976855
View directory record Official record
Conditions
Healthy Volunteer, Opioid-use Disorder
Interventions
INDV-2000, Placebo, SUBOXONE® sublingual film
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
3
States / cities
Baltimore, Maryland • DeSoto, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 1 Interventional

Gradual Vs. Rapid Buprenorphine Detoxification - 2

NCT00000220
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Buprenorphine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
33 Years to 43 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1991 – 2001
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 25, 2026, 5:42 AM EDT
Not yet recruiting Phase 1 Interventional

Cannabis Effects on Opioid Self-Administration

NCT07668635
View directory record Official record
Conditions
Opioid Use Disorder, Cannabis Use
Interventions
Cannabis, Placebo Cannabis, Intranasal Opioid Agonist, Oral Opioid Agonist
Drug
Lead sponsor
Shanna Babalonis, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 3 Interventional Results available

Blinded Trial of Buprenorphine or Morphine in the Treatment of the Neonatal Abstinence Syndrome

NCT01452789
View directory record Official record
Conditions
Neonatal Abstinence Syndrome
Interventions
sublingual buprenorphine, oral morphine
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
Not listed
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention

NCT03336268
View directory record Official record
Conditions
Substance Use Disorders, Overdose
Interventions
POINT
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Oct 25, 2026, 5:42 AM EDT
Terminated No phase listed Observational

Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients

NCT03925610
View directory record Official record
Conditions
Morbid Obesity, Opioid-Related Disorders, Surgery--Complications, Sleep Apnea Syndromes
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients

NCT00577005
View directory record Official record
Conditions
Cocaine Dependence, Opioid Dependency
Interventions
levetiracetam, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 2 Interventional

Relational Parenting Group for Opioid-addicted Mothers

NCT00319241
View directory record Official record
Conditions
Substance Abuse, Child Abuse
Interventions
Parenting Intervention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Prospective Cohort of Opiate Dependent Patients on Buprenorphine/Naloxone for Maintenance

NCT00622596
View directory record Official record
Conditions
Opiate Dependence
Interventions
Mobile Access
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 24, 2016 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD

NCT03658642
View directory record Official record
Conditions
Clinical Decision Support, Buprenorphine, Opioid-use Disorder
Interventions
Clinical Decision Support (CDS)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
5,047 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
22
States / cities
Birmingham, Alabama • Gardendale, Alabama • Aurora, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Stress, Distress Intolerance, and Drug Dependence

NCT00430482
View directory record Official record
Conditions
Substance Dependence
Interventions
Cognitive Behavioral Therapy, Individual Counseling
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 70 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 4 Interventional Results available

Rapid Initiation of Drug Treatment Engagement

NCT03908437
View directory record Official record
Conditions
Opioid-use Disorder, Overdose
Interventions
buprenorphine/naloxone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aprepitant Effects on Oxycodone Response

NCT00999544
View directory record Official record
Conditions
Narcotic Abuse
Interventions
Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg, Oxycodone 0mg, p.o., Oxycodone 20mg, p.o., Oxycodone 40mg, p.o., Oxycodone 0mg, IN, Oxycodone 15mg, IN, Oxycodone 30mg, IN
Drug
Lead sponsor
Sharon Walsh
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 1, 2017 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 2 Interventional Results available

Glutamatergic Modulation to Facilitate Naltrexone Initiation in Opioid Dependence

NCT02437344
View directory record Official record
Conditions
Opioid Dependence
Interventions
CI-581aa, Naltrexone titration and XR-NTX initiation
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 1Phase 2 Interventional

Medication Adherence Therapy for Opioid Abusing Pain Patients

NCT00249587
View directory record Official record
Conditions
Pain, Chronic Disease, Prescription Opioid Abuse
Interventions
Methadone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 2 Interventional Results available

Naltrexone and Memantine Effects on Alcohol Drinking Behaviors

NCT01519063
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Naltrexone and memantine first, Naltrexone and Placebo first
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Phase 3 Interventional Results available

Extended-Release Naltrexone for Opioid Relapse Prevention Following Release From Jail

NCT01180647
View directory record Official record
Conditions
Opiate Dependence
Interventions
Extended-Release Naltrexone, Motivational Enhancement Counseling
Drug · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Cell Phone Technology Targeting ART Adherence and Drug Use

NCT01884233
View directory record Official record
Conditions
HIV, Opioid Abuse
Interventions
Standard Care, Text Messaging CBT (TXT-CBT)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Emergency Department Longitudinal Integrated Care

NCT03699085
View directory record Official record
Conditions
Opioid-use Disorder, Emergency Department
Interventions
ED-LINC
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sex and Female Empowerment

NCT02197715
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Computer-adaptive SAFE, Face-to-face SAFE, Usual Care
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Oct 25, 2026, 5:42 AM EDT
Not yet recruiting Not applicable Interventional

MedSMA℞T Mobile ED

NCT06848504
View directory record Official record
Conditions
Opiate-Related Disorders, Opiate Use Disorder, Opioid
Interventions
MedSMA℞T Mobile
Behavioral
Lead sponsor
Olufunmilola Abraham
Other
Eligibility
12 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
3
States / cities
Rockford, Illinois • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 25, 2026, 5:42 AM EDT
Active, not recruiting Not applicable Interventional

Peer Recovery Support Services for Individuals in Recovery Residences on MOUD

NCT05616949
View directory record Official record
Conditions
Opioid Use Disorder, Substance Use Disorder
Interventions
Treatment as Usual (TAU) (Arm 1), Peer Recovery Support Services (PRSS) + TAU (experimental- Arm 2)
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 25, 2026, 5:42 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder: CTN 0075

NCT03248947
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
buprenorphine/naloxone, Pharmacist-administered buprenorphine/naloxone maintenance care
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
6
States / cities
Durham, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 28, 2021 · Synced Oct 25, 2026, 5:42 AM EDT