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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:41 PM EDT

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Showing 121–144 of 1,476 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Opioid Related Disorders Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Digital Health Intervention to Support Opioid Use Disorder Treatment

NCT03842384
View directory record Official record
Conditions
Opioid Use Disorder, Treatment Adherence
Interventions
iENDURE
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional

No Opioids PrescrIptions On Discharge After Surgery

NCT04469868
View directory record Official record
Conditions
Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
Interventions
No opioids at discharge
Behavioral
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Buprenorphine Naltrexone-P1 A-Cocaine

NCT00733720
View directory record Official record
Conditions
Cocaine-related Disorders
Interventions
Suboxone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 20, 2026, 11:41 PM EDT
Recruiting Phase 3 Interventional

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

NCT06387290
View directory record Official record
Conditions
Chronic Pain, Prescription Opioid Misuse, Substance-Related Disorders, Pain, Narcotic-Related Disorders, Chemically-Induced Disorders, Mental Disorders, Opioid-Related Disorders, Neurologic Manifestations
Interventions
Mindfulness Oriented Recovery Enhancement, Patient-Centered Chronic Pain Management Visits
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
La Jolla, California • New Brunswick, New Jersey • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Active, not recruiting Not applicable Interventional

Mobile Platform for Optimizing Wellness and Engagement in Recovery

NCT07178990
View directory record Official record
Conditions
Opioid Agonist Treatment, Alcohol Use Disorder, Opioid Use Disorder
Interventions
Digital Contingency Management Intervention Arm, Digital Wellness Arm
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
19 Years to 63 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Terminated Not applicable Interventional

Cognitive Functioning in Opioid Use Disorder

NCT05001789
View directory record Official record
Conditions
Opioid Use, Cognitive Change, Opioid-use Disorder
Interventions
CogMed
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 20, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

NCT06718491
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention

NCT03336268
View directory record Official record
Conditions
Substance Use Disorders, Overdose
Interventions
POINT
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional

START NOW in the Treatment of Opioid Addicted Individuals

NCT05552040
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
START NOW Group
Behavioral
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2022 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Alliances to Disseminate Addiction Prevention and Treatment (ADAPT)

NCT04499079
View directory record Official record
Conditions
Substance-Related Disorders, Recidivism, Opioid-Related Disorders, Substance Use, Criminal Behavior
Interventions
Learning Health System
Other
Lead sponsor
Indiana University
Other
Eligibility
11 Years and older
Enrollment
7,316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2

NCT07602218
View directory record Official record
Conditions
Opioid Use Disorder, Clinical Decision Support
Interventions
Refined EMBED CDS, Provider alert to order consultation with addiction counselor
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
3
States / cities
Guilford, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia

NCT00218374
View directory record Official record
Conditions
Hyperalgesia, Opioid-Related Disorders
Interventions
Gabapentin
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 20, 2026, 11:41 PM EDT
Recruiting Phase 4 Interventional

Low-dose Buprenorphine Initiation for Opioid Use Disorder

NCT05450718
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
buprenorphine-naloxone
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Not listed No phase listed Observational

Improving Treatment and Recovery Services for Individuals With Opioid Problems

NCT05129813
View directory record Official record
Conditions
Counseling
Interventions
Recovery Guide Counseling
Behavioral
Lead sponsor
Howard University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Oct 20, 2026, 11:41 PM EDT
Enrolling by invitation Not applicable Interventional

Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails

NCT07490717
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder, Stimulant Use & Co-occuring Opioid Use Disorders, Co-occurring Mental and Substance Use Disorders, Medications for Opioid Use Disorder
Interventions
Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Phase 1Phase 2 Interventional Results available

The Discriminative Effects of Tramadol in Humans

NCT00499746
View directory record Official record
Conditions
Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
Interventions
tramadol, placebo, Hydromorphone, Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Months to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Oct 20, 2026, 11:41 PM EDT
Completed No phase listed Observational

Study of Buprenorphine Maintenance Treatment for Opioid Dependence in Primary Care

NCT00471042
View directory record Official record
Conditions
Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
Interventions
Buprenorphine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional Results available

Assessing the Efficacy of Self-Driven Repetitive Artmaking Practice

NCT06554431
View directory record Official record
Conditions
Chronic Pain, Opioid Use Disorder, Opioid Misuse, Opioid-Related Disorders
Interventions
Self-Driven Repetitive Artmaking
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Phase 1 Interventional

Single Ascending Dose Study of RBP-6000

NCT03002961
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
RBP-6000, Suboxone
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 26, 2016 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Using Artificial Intelligence To Monitor Medication Adherence in Opioid Replacement Therapy

NCT02243670
View directory record Official record
Conditions
Opiate Addiction, Medication Non-adherence, Addiction, Opioid Dependence
Interventions
AiCure monitoring and intervention
Device
Lead sponsor
AiCure
Industry
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 12, 2017 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Phase 2 Interventional Results available

Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration

NCT01880086
View directory record Official record
Conditions
Hypogonadism, Opioid-Related Disorders, Male Infertility
Interventions
Clomiphene citrate, Placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Oct 20, 2026, 11:41 PM EDT
Active, not recruiting Not applicable Interventional

Mobile Peer Support for OUD Recovery

NCT05405712
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Mobile Phone App
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
1,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Indianapolis, Indiana • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 20, 2026, 11:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

INDV-2000 First in Human

NCT04413552
View directory record Official record
Conditions
Opioid Dependence
Interventions
INDV-2000, Placebo
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 20, 2026, 11:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Reported Outcomes for Opioid Use Disorder

NCT03985163
View directory record Official record
Conditions
Opioid-use Disorder, Overdose of Opiate, Patient Participation
Interventions
Patient Reported Outcomes Electronic Survey
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2024 · Synced Oct 20, 2026, 11:41 PM EDT