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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Opioid Use Disorder Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

AvertD Post-Approval Study

NCT07135323
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Opioid Used Disorder Risk Assessment
Genetic
Lead sponsor
Prescient Medicine Holdings, Inc.
Industry
Eligibility
18 Years and older
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use

NCT04808479
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
imFREE mCBT, mHealth ED
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Tarzana, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Not yet recruiting Not applicable Interventional

Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs

NCT07631559
View directory record Official record
Conditions
HEPATITIS C (HCV), Opioid Use Disorder, Substance Use Disorder (SUD), Drug Use Disorders, Healthcare Access, Harm Reduction
Interventions
Partner navigation intervention booster session
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Youth Opioid Recovery Support: Improving Care Systems

NCT04015115
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Youth Opioid Recovery Support service model
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 26 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 6, 2022 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP

NCT05108935
View directory record Official record
Conditions
Opioid Use, Opioid Use Disorder, Risk Reduction, Hiv, Hepatitis C
Interventions
Suboxone, Truvada, Mavyret
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Durham, North Carolina • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

Primary Care Intervention to Reduce Prescription Opioid Overdoses

NCT02464410
View directory record Official record
Conditions
Pain, Drug Overdose, Opioid Use Disorders
Interventions
Motivational intervention, Psycho-educational control, Long-term opioid therapy informed consent
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 23, 2026, 2:08 AM EDT
Withdrawn Not applicable Interventional

Virtual MOUD Treatment- Virtual POC Toxicology

NCT05448118
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Virtual POC Toxicology Test
Diagnostic Test
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
West Haven, Connecticut • Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 26, 2023 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

PRoducing Outcome Measures for OTP Quality Improvement

NCT07214389
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Quality Measures (Audit and Feedback), Quality Improvement (QI) Toolkit, External QI Facilitation
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
4,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

NavSTAR Implementation Effectiveness Trial Across a Health System

NCT07262190
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
NavSTAR (Philly adaptation)
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
720 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 1 Interventional

Medication-Assisted Treatment for Youth With Substance Use Disorders

NCT02593474
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Dependence
Interventions
Naltrexone
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
16 Years to 25 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Phase 4 Interventional

Injectable Buprenorphine in Prison: A Preference Trial

NCT06880718
View directory record Official record
Conditions
Opioid Use Disorder, Incarceration, Medications for Opioid Use Disorder, Buprenorphine
Interventions
Brixadi (Injectable Buprenorphine), Sublocade
Drug
Lead sponsor
Lifespan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Music Therapy in the Treatment of Perioperative Anxiety and Pain

NCT05263635
View directory record Official record
Conditions
Pain, Post Operative, Anxiety, Opioid Use
Interventions
Music therapy, Standard of Care Enhanced Recovery After Surgery (ERAS)
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

NCT06157840
View directory record Official record
Conditions
Opioid Use Disorder, Poor Quality Sleep
Interventions
mHealth application and sleep health education, Simplified mHealth application and sleep health education
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Adaptive Decision Support for Addiction Treatment Master

NCT06799117
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
EMBED CDS, Nurse prompt to complete COWS, Provider Prompt, Patient facing materials, Optimized EMBED, Name of Intervention
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
1,912 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Guilford, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 3 Interventional Results available

Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)

NCT02537574
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
20
States / cities
Oceanside, California • Orange, California • Lauderhill, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

NCT06573476
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
PRC supported text + AI driven CSDH-enhanced text, AI driven CSDH-enhanced text only, Treatment as Usual (TAU)
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 99 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 2Phase 3 Interventional

Tobacco Use in Opioid Agonist Treated Pregnant Women

NCT00497068
View directory record Official record
Conditions
Nicotine Dependence
Interventions
tobacco abstinent contingent, non-contingent, control
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2013 · Synced Jul 23, 2026, 2:08 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effective Caregiving for Neonatal Abstinence Syndrome: Testing an Instructional Mobile Technology Platform for High-Risk Pregnant Women

NCT04783558
View directory record Official record
Conditions
Neonatal Abstinence Syndrome, Opioid-use Disorder
Interventions
Mobile-based NAS Caregiving Tool
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 1 Interventional

Single Ascending Dose Study of ALA-1000

NCT04122755
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
ALA-1000, buprenorphine sublingual film
Drug
Lead sponsor
Alar Pharmaceuticals Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 29, 2021 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Phase 4 Interventional

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

NCT05669534
View directory record Official record
Conditions
Hiv, Opioid Use Disorder
Interventions
community-friendly health recovery program, Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis
Behavioral · Drug
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction

NCT07344233
View directory record Official record
Conditions
Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
Interventions
Real-time fMRI Neurofeedback, Sham Real-time fMRI Neurofeedback
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 64 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting No phase listed Observational

Cannabis Use and Outcomes in Black and White Patients With Cancer

NCT06037681
View directory record Official record
Conditions
Cancer
Interventions
Not listed
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
21 Years to 99 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
Buffalo, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 2 Interventional

Proof of Concept and Dose-ranging Study of INDV-2000 in Individuals With Moderate to Severe Opioid Use Disorder

NCT06384157
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
INDV-2000, Placebo
Drug · Other
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
35
States / cities
Hamilton, Alabama • Phoenix, Arizona • Oceanside, California + 29 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Night Respite for Postpartum Mothers With SUD

NCT05746507
View directory record Official record
Conditions
Opioid Use Disorder, Maternal Drugs Affecting Fetus, Postpartum Mood Disturbance, Sleep Disorder, Neonatal Opioid Withdrawal
Interventions
Night Respite Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Mattapan, Massachusetts • Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 23, 2026, 2:08 AM EDT