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ClinicalTrials.gov public records Last synced Nov 7, 2026, 4:14 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 163 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Optical Imaging Clear all

Conditions: Ulcer Foot, Diabetes
Interventions: SFDI Imaging; Device
Lead sponsor: Modulated Imaging Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Non-Melanoma Skin Cancer (NMSC)
Interventions: OFDI; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Epilepsy, Neurologic Manifestations
Interventions: intraoperative infrared (IR) neuroimaging; Device
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: Not listed
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2000
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Dehydration
Interventions: GENPOP Passive dehydration (75% reduction in fluid intake, GENPOP Ad lib fluid intake, EXERCISE without fluid replacement, EXERCISE with fluid replacement; Other
Lead sponsor: PepsiCo Global R&D; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: Valhalla, New York • Plano, Texas

Conditions: Hematologic Malignancy
Interventions: AM4113-N5UT Dino-Lite; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Eye Diseases, Healthy Volunteers
Interventions: Not listed
Lead sponsor: National Eye Institute (NEI); NIH
Eligibility: 12 Years to 120 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2028
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: AMD, Cancer, Cataract
Interventions: Not listed
Lead sponsor: National Eye Institute (NEI); NIH
Eligibility: 50 Years and older
Enrollment: 709 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Fuch's Dystrophy, Corneal Disorders, Prior Surgery
Interventions: Not listed
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2024
U.S. locations: 2
States / cities: New York, New York • Pittsburgh, Pennsylvania

Conditions: Retinal Vasculitis
Interventions: Not listed
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Barrett's Esophagus
Interventions: MGH OFDI marking; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Undergoing Esophagogastroduodenoscopy (EGD)
Interventions: Not listed
Lead sponsor: NinePoint Medical; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Breast Cancer
Interventions: Disease Group, Control Group; Device
Lead sponsor: University of California, Irvine; Other
Eligibility: 21 Years to 90 Years · Female only
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2017
U.S. locations: 1
States / cities: Irvine, California

Conditions: Barrett's Esophagus, Eosinophilic Esophagitis
Interventions: OFDI Capsule; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 16 Years and older
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Kidney Disease
Interventions: Procedure/Surgery: Transplantation: OCT of Kidney Transplant; Procedure
Lead sponsor: Georgetown University; Other
Eligibility: Not listed
Enrollment: 169 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Barrett's Esophagus
Interventions: Experimental OFDI Imaging; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 85 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: Observation of Ocrelizumab as Treatment in RRMS Patients; Other
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
Interventions: Not listed
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Coronary Artery Disease
Interventions: Evolocumab Injections; Drug
Lead sponsor: Annapoorna Kini; Other
Eligibility: 18 Years and older
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Breast Cancer
Interventions: 3-D Optical Surface Scan, Mechanical Testing, Cutaneous Ultrasound, Breast MRI and/or CT; Procedure
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Sickle Cell Disease, Cerebral Stroke
Interventions: Carbon Dioxide; Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 6 Years to 70 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2032
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Retinal Vein Occlusions
Interventions: Not listed
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Multiple Sclerosis
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Bethesda, Maryland • Salt Lake City, Utah

Conditions: Characterize Gel Distribution in the Vagina, Study Women's Sensory Perceptions and Preferences of Gel
Interventions: vaginal gel imaging, computer aided self interview; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 45 Years · Female only
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Oral Tumors
Interventions: FastEEM4 System, Multispectral Digital Microscope; Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2017
U.S. locations: 1
States / cities: Houston, Texas

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Optical Imaging For Assessment of Foot Perfusion

Optical Frequency Domain Imaging for Non-melanoma Skin Cancers

Infrared Camera for Brain Mapping During Surgery

Utility of Transdermal Optical Imaging (TOI) as a Non-invasive Measure of Hydration Status: Phase 3a for Model Development

Non Invasive Optical Imaging of WBC Count

Adaptive Optics Retinal Imaging

Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On

Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye

Optical Coherence Tomography (OCT) in Retinal Vasculitis

Optical Frequency Domain Imaging (OFDI) Surveillance and Image Guided Biopsy of the Esophagus

High Resolution Optical Imaging of the Esophagus Using the Nvision Volumetric Laser Endomicroscopy (VLE™) Imaging System

Combined MRI and Optical Imaging to Improved Breast Cancer Diagnosis

Study to Image the Esophagus Using the OFDI Capsule

Non-Invasive Evaluation of Transplant Kidney Using OCT

Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System

Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis

PIONEER: Intraoperative and Perioperative OCT Study

Effect of Evolocumab on Coronary Plaque Characteristics

3-Dimensional Form and Soft Tissue Biomechanics of the Breast

Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography

OCT in Retinal Vein Occlusions

Natural History of Optic Neuritis

Optical Imaging and User Perception Study of Vaginal Gel

Oral Margin Spectroscopy Detection Using Optical Spectroscopy