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ClinicalTrials.gov public records Last synced Nov 7, 2026, 5:24 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 163 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Optical Imaging Clear all

Conditions: Squamous Cell Lung Cancer, Lung Cancer
Interventions: Not listed
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Barrett's Esophagus
Interventions: Optical Frequency Domain Imaging (OFDI); Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: Not listed
Enrollment: 109 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Retinal Vascular Disease
Interventions: Swept-Source Optical Coherence Tomography; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Hepatocellular Carcinoma
Interventions: Optical Molecular Imaging (OMI), Indocyanine Green (ICG), Electromagnetic Tracking; Device · Radiation
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Neuromyelitis Optica Spectrum Disorder, NMOSD
Interventions: Satralizumab 120 mg; Drug
Lead sponsor: Hoffmann-La Roche; Industry
Eligibility: 18 Years to 74 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
Interventions: Coronary PCI guided by OCT, Coronary PCI guided by Angiography; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 2,487 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 42
States / cities: Birmingham, Alabama • Scottsdale, Arizona • Burlingame, California + 37 more

Conditions: Carcinoma, Basal Cell, Carcinoma, Squamous Cell
Interventions: Polarization Enhanced Reflectance and Fluorescence System; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Breast Cancer
Interventions: DOSI; Procedure
Lead sponsor: American College of Radiology Imaging Network; Network
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Irvine, California • Lebanon, New Hampshire

Conditions: Retinal Disease, Glaucoma, Optic Nerve Diseases
Interventions: Investigational contact OCT system, Investigational noncontact OCT system:; Device
Lead sponsor: Duke University; Other
Eligibility: Not listed
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Amputation Wound, Peripheral Arterial Disease
Interventions: SpectralMD DeepView Wound Imaging System 2.0; Device
Lead sponsor: SpectralMD; Industry
Eligibility: 18 Years and older
Enrollment: 55 participants
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Plano, Texas

Conditions: Breast Cancer
Interventions: Optical coherence tomography; Device
Lead sponsor: Diagnostic Photonics, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 2
States / cities: Annapolis, Maryland • Baltimore, Maryland

Conditions: Collagen Fibril Alteration
Interventions: Tretinoin cream 0.1%; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 45 Years and older · Female only
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Irvine, California

Conditions: Port-wine Stain
Interventions: Photo Acoustic Microscopy and Optical Coherence tomography; Device
Lead sponsor: University of California, Irvine; Other
Eligibility: Not listed
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Irvine, California

Conditions: Pancreatic Carcinoma, Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type
Interventions: Optical Coherence Tomography, Therapeutic Conventional Surgery, Laboratory Evaluation; Procedure · Diagnostic Test
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Trauma Injury, Trauma, Open Fracture, Fracture Infection
Interventions: Open Fracture, Infected Fracture; Procedure
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Squamous Cell Lung Cancer, Lung Cancer, Pulmonary Disease
Interventions: Optical Frequency Domain Imaging (OFDI) System; Device
Lead sponsor: Lahey Clinic; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: Burlington, Massachusetts

Conditions: Myofascial Pain
Interventions: Multi-modal, multi-parametric, multiscale imaging of the myofascial unit; Diagnostic Test
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 80 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Adenocarcinoma of the Prostate, Stage IIB Prostate Cancer, Stage III Prostate Cancer, Stage IV Prostate Cancer
Interventions: anti-PSMA monoclonal antibody MDX1201-A488, robot-assisted laparoscopic surgery, diffuse optical imaging, pharmacological study, Laboratory Biomarker, Questionnaire; Biological · Procedure · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 36 Years to 74 Years · Male only
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2023
U.S. locations: 1
States / cities: Duarte, California

Conditions: Breast Cancer
Interventions: miniature spectral imaging system, Bench-top optical spectrometer, High resolution microendoscope; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 218 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 2
States / cities: Durham, North Carolina • Madison, Wisconsin

Conditions: Acute Myocardial Infarction, STEMI, Coronary Artery Disease, Atherosclerotic Plaque Disruption With Thrombosis of Artery
Interventions: Coronary Angiography; Procedure
Lead sponsor: Corewell Health East; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Blindness
Interventions: Not listed
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Hepatocellular Carcinoma
Interventions: ICG, Optical molecular imaging; Biological · Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Transthyretin Amyloid Cardiomyopathy
Interventions: Not listed
Lead sponsor: AstraZeneca; Industry
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 6
States / cities: Palo Alto, California • Jacksonville, Florida • Chicago, Illinois + 3 more

Conditions: Multiple Sclerosis
Interventions: Not listed
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Portland, Oregon

Search by objective public record fields.

Pilot Study to Evaluate Optical Frequency Domain Imaging for Diagnosis of Central Airway Disease

Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction

Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging

Electromagnetic Tracking and Optical Imaging With ICG for Hepatic Biopsies

A Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention

ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)

Optical Imaging for Preoperative Delineation of Nonmelanoma Skin Cancers

Monitoring and Predicting Chemotherapy Response Using DOSI

Optimize Pediatric OCT Imaging

Wound Imaging Study to Gather Clinical References for a Device to Assist Selecting Level-of-amputation in PAD Patients

Computed Optical Margin Assessment for Breast Cancer Surgery, Phase I (Part A)

Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

Evaluate the Port-wine Stain Birthmark Treatment Before and After Pulsed Dye Laser Treatment

Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

OCT in Open Fracture and Infected Fracture

Pilot Study To Evaluate Optical Frequency Domain Imaging For Diagnosis Of Central Airway Disease

Multi-modal Imaging of Myofascial Pain

Intra-operative Optical Imaging With MDX1201-A488 in Patients With Prostate Cancer

A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins

Multi-modality Imaging in Acute Myocardial Infarction

Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours

A Pilot Study of Optical Molecular Imaging for Percutaneous Biopsy of Hepatocellular Carcinoma Using Indocyanine Green

Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM

Using Optical Coherence Tomography to Capture Retinal Microvascular Changes Associated With Multiple Sclerosis