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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:01 AM EDT

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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Oral Microbiota Clear all
Recruiting Early Phase 1 Interventional

Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC

NCT06197308
View directory record Official record
Conditions
Primary Sclerosing Cholangitis
Interventions
oral vancomycin and oral amoxicillin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 76 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Orthodontic Varnish Microbiology Study

NCT04528134
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biogeography of the Oral Microbiome

NCT05672953
View directory record Official record
Conditions
Oral Microbiome
Interventions
Not listed
Lead sponsor
Viome
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers

NCT02439255
View directory record Official record
Conditions
Healthy Subject, Tobacco Use Disorder
Interventions
Laboratory Biomarker Analysis, Phytochemical, Placebo, Screening Questionnaire Administration
Other · Dietary Supplement
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 50 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 5, 2022 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Phase 1 Interventional

Chlorhexidine Gel Therapy for Cariogenic Oral Microflora

NCT01036412
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
1% Chlorhexidine Gluconate Gel, Surveys
Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 19, 2016 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults

NCT01376791
View directory record Official record
Conditions
Periodontal Disease, Atherosclerosis
Interventions
Not listed
Lead sponsor
San Diego State University
Other
Eligibility
21 Years to 40 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Valley Center, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2013 · Synced Oct 20, 2026, 7:01 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

New Functional Ingredient for Oral Care

NCT07771907
View directory record Official record
Conditions
Oral Health Related Quality of Life (OHRQoL)
Interventions
Botanical A, Botanical B, Vehicle (Placebo solution)
Dietary Supplement
Lead sponsor
Access Business Group
Industry
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Oral Microbiome and Pancreatic Cancer

NCT03302637
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
16S rRNA gene sequencing assay
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
55 Years to 74 Years
Enrollment
732 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational

Study of Variation Over Time in the Oral Microbiome

NCT02049398
View directory record Official record
Conditions
Microbiota, Oral Health, Body Mass Index
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 27, 2020 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Phase 4 Interventional

A Peri-intubation Oral Intervention to Reduce Oral Flora and VAP

NCT00248300
View directory record Official record
Conditions
Pneumonia
Interventions
Chlorhexidine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational

Topical Antisepsis in Head and Neck Cancer Surgery

NCT04721626
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Chlorhexidine Gluconate, Povidone-iodine, Tetracycline Ointment
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Probiotic for Oral Health (PRO Health) Study

NCT03748017
View directory record Official record
Conditions
Oral Microbiome
Interventions
Placebo-Control Supplement, Streptococcus-Containing Probiotic Supplement
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
21 Years to 45 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational

Long-Term Stability of Oral Microbiome Samples

NCT03068546
View directory record Official record
Conditions
Oral Microbiota, Long Term Sample Stability
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Phase 1 Interventional

Safety of FMT Using Oral Encapsulated PRIM-DJ2727 in HIV

NCT03329560
View directory record Official record
Conditions
HIV-1-infection
Interventions
Oral fecal microbiota transplantation
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Male only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Phase 1 Interventional

Evaluating the Safety and Efficacy of Oral Encapsulated Fecal Microbiota Transplant in Peanut Allergic Patients

NCT02960074
View directory record Official record
Conditions
Peanut Allergy
Interventions
Fecal Microbiota Capsule
Biological
Lead sponsor
Rima Rachid
Other
Eligibility
18 Years to 40 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 20, 2026, 7:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Mouthrinse on the Microbiome of the Oral Cavity and GI Tract

NCT05603650
View directory record Official record
Conditions
Oral Bacterial Infection, Oral Infection, Microbial Colonization, Viral Infection
Interventions
Lumineux Oral Essentials rinse, Listerine rinse
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 20, 2026, 7:01 AM EDT
Not listed Phase 1Phase 2 Interventional

Safety Evaluation of Fecal Microbiota Transplantation in Severe Alcoholic Hepatitis

NCT05006430
View directory record Official record
Conditions
Alcoholic Hepatitis
Interventions
Fecal Microbiota Transplantation, Placebo
Biological · Other
Lead sponsor
Prasun Kumar Jalal
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational

Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancies

NCT05462314
View directory record Official record
Conditions
Gastrointestinal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer, Rectal Cancer, Liver Cancer, Biliary Cancer
Interventions
Not listed
Lead sponsor
Viome
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer

NCT03304132
View directory record Official record
Conditions
Oral Cancer
Interventions
Classification of Oral Microbiome Using 16S rRNA gene sequence-based approach, Classification of Oral Microbiome Using taxonomic approach
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 92 Years
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2017 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)

NCT01198509
View directory record Official record
Conditions
Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
Interventions
doxycycline, vancomycin
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
178 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 13, 2015 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Probiotic Water on Oral Health in Adults

NCT04473404
View directory record Official record
Conditions
Oral Bacteria, Halitosis
Interventions
Streptococcus salivarius DB-B5 - 2 billion CFU/day, Streptococcus salivarius DB-B5 - 10 billion CFU/day, Placebo
Dietary Supplement · Other
Lead sponsor
Dose Biosystems Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 4, 2020 · Synced Oct 20, 2026, 7:01 AM EDT
Recruiting Phase 1Phase 2 Interventional

Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)

NCT06097468
View directory record Official record
Conditions
Oral Cavity Squamous Cell Carcinoma
Interventions
NisinZ® P, Surgery (non-interventional, standard of care)
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 20, 2026, 7:01 AM EDT
Completed Not applicable Interventional

The Oral Microbiome in OSCC

NCT04925700
View directory record Official record
Conditions
Oral Cancer
Interventions
ProDentis Lozenge, Placebo Lozenge
Dietary Supplement · Other
Lead sponsor
University of Iowa
Other
Eligibility
21 Years to 89 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 20, 2026, 7:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sweet Cheeks: How Early Nutrition Affects Oral Microbiota Populations and Disease Incidence

NCT01836952
View directory record Official record
Conditions
Health Behavior
Interventions
Not listed
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
2 Days to 7 Months
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Oct 20, 2026, 7:01 AM EDT