- Conditions
- Opioid Use Disorder, Opioid Use, Insomnia, Orexin Antagonist
- Interventions
- Placebo, Lemborexant 10 MG
- Drug
- Lead sponsor
- Virginia Commonwealth University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2029
- U.S. locations
- 1
- States / cities
- Richmond, Virginia
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Showing 1–10
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- Conditions
- Shift-Work Related Sleep Disturbance
- Interventions
- Lemborexant, Placebo
- Drug
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 20 Years to 60 Years
- Enrollment
- 29 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
- Interventions
- Suvorexant 20 mg, Placebo oral tablet
- Drug
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 2
- States / cities
- Boston, Massachusetts • The Bronx, New York
- Conditions
- Opioid Use Disorder, Stimulant Use Disorder
- Interventions
- Suvorexant (dual orexin receptor antagonist), Placebo
- Drug
- Lead sponsor
- Johns Hopkins University
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Cue-reactivity, Cannabis Use Disorder, Functional MRI, Orexin Antagonist
- Interventions
- Suvorexant
- Drug
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Healthy Volunteers
- Interventions
- Almorexant, Zolpidem 10mg, Placebo
- Drug
- Lead sponsor
- Northern California Institute of Research and Education
- Other
- Eligibility
- 19 Years to 39 Years
- Enrollment
- 203 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2014
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Sleep Initiation and Maintenance Disorders, Stress Disorders, Posttraumatic
- Interventions
- Suvorexant, Placebo
- Drug · Other
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 190 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2025
- U.S. locations
- 4
- States / cities
- Long Beach, California • San Francisco, California • Salisbury, North Carolina + 1 more
- Conditions
- Suicide Risk, Major Depressive Disorder (MDD)
- Interventions
- Suvorexant (dual orexin receptor antagonist)
- Drug
- Lead sponsor
- Marianne Goodman
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 1
- States / cities
- The Bronx, New York
- Conditions
- Alzheimer Disease
- Interventions
- Lemborexant 10 mg, Lemborexant 20mg, Placebo
- Drug
- Lead sponsor
- University of Minnesota
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 201 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024 – 2030
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Advanced Malignant Solid Neoplasm, Delirium, Hematopoietic and Lymphatic System Neoplasm, Insomnia
- Interventions
- Best Practice, Electronic Health Record Review, Interview, Questionnaire Administration, Suvorexant
- Other · Drug
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota