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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Orthodontic Treatment Clear all
Completed No phase listed Observational Accepts healthy volunteers

The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances

NCT04186065
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Hiroko Nagaoka
Other
Eligibility
10 Years to 70 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse

NCT04512482
View directory record Official record
Conditions
Dental Plaque, Dental Caries
Interventions
Bromelain, Powdered sugar
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
10 Years to 25 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficiency of Piezotome-Corticision Assisted Orthodontics

NCT02026258
View directory record Official record
Conditions
Mandibular Anterior Crowding, Piezocision, Pain Perception
Interventions
Piezotome-Corticision, Orthodontics
Procedure · Device
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 6, 2017 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients

NCT04560478
View directory record Official record
Conditions
White Spot Lesion
Interventions
Pro Seal Sealant, MI Varnish
Device
Lead sponsor
Texas A&M University
Other
Eligibility
12 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy

NCT02119455
View directory record Official record
Conditions
Tooth Movement
Interventions
Vibration Device
Device
Lead sponsor
UConn Health
Other
Eligibility
15 Years to 35 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Sep 29, 2026, 4:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Miniscrew Stability and Peri-implant Inflammation When Precoated K21 vs Ethanol Control

NCT05639907
View directory record Official record
Conditions
Inflammation Caused by the Placement of a Temporary Anchorage Device
Interventions
K21 Cavity cleanser, Ethanol control
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Results available

Accelerated Invisalign Therapy in Conjunction With Acceledent Aura

NCT02868554
View directory record Official record
Conditions
Malocclusion
Interventions
AcceleDent Aura, Accelerated Invisalign therapy
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 29, 2026, 4:49 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances

NCT03202355
View directory record Official record
Conditions
Malocclusion
Interventions
Fixed Appliance Orthodontic Treatment, OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
3
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 7, 2019 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners

NCT01962012
View directory record Official record
Conditions
Malocclusion
Interventions
AcceleDent Aura, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Sep 29, 2026, 4:49 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Comparison of the Alignment Achieved Using Computer-guided Indirect Bonding of Orthodontic Brackets to Conventional Appliance Placement

NCT02221856
View directory record Official record
Conditions
Malocclusion
Interventions
Motion View, Conventional Orthodontic Treatment
Procedure
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
Up to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Results available

Effect of Intra-Oral Photobiomodulation on Orthodontic Treatment Time

NCT02267850
View directory record Official record
Conditions
Malocclusion
Interventions
Fixed Orthodontic Appliance Treatment, OrthoPulse™, Non-Functional OrthoPulse™
Other · Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
12 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 20, 2018 · Synced Sep 29, 2026, 4:49 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

The Effect of Tooth Position During Orthodontic Treatment on the Apnea/ Hypopnea Index (AHI)

NCT03299023
View directory record Official record
Conditions
Obstructive Sleep Apnea, Orthodontic Tooth Movement, Apnea, Sleep Disordered Breathing
Interventions
Medibyte Portable Monitor
Other
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
8 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Sep 29, 2026, 4:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive

NCT07091422
View directory record Official record
Conditions
Bracket Bonding, Orthodontic Treatment, Dental Adhesives/Restorations Performance, White Spot Lesion of Tooth
Interventions
Etch-Free Adhesive, Conventional Etch-and-Bond Adhesive
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of the Efficacy of the Aerodentis System

NCT03421886
View directory record Official record
Conditions
Orthodontic Treatment, Tooth Crowding, Orthodontics
Interventions
Aerodentis system, Invisalign clear aligner system
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 29, 2026, 4:49 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

OrthoPulse 2.0 and 2.1 Feasibility Evaluation

NCT03683017
View directory record Official record
Conditions
Malocclusion
Interventions
OrthoPulse 2.0, OrthoPulse 2.1, Invisalign 3.5 Day Wear, Fixed Orthodontic Appliances (Braces)
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
6
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Sep 29, 2026, 4:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study of the Use of Orthopulse Photobiomodulation

NCT05650359
View directory record Official record
Conditions
Orthodontics
Interventions
OrthoPulse, No intervention
Device · Other
Lead sponsor
Biolux Technology GmbH
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chandler, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional

Effectiveness of Ortho-Buddy on Plaque Control in Orthodontic Patients

NCT07810868
View directory record Official record
Conditions
Dental Plaque Accumulation
Interventions
Standard Toothbrush, Ortho-Buddy
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
11 Years to 18 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 29, 2026, 4:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery

NCT06122805
View directory record Official record
Conditions
Toothbrushing, Gingivitis, Cleft Lip and Palate
Interventions
Toothbrush
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
6 Years to 20 Years
Enrollment
198 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 12, 2024 · Synced Sep 29, 2026, 4:49 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effect of Low Level Laser Therapy on Pain Induced by Placement of Orthodontic Separators in Pediatric Patients

NCT02211547
View directory record Official record
Conditions
Levels of Pain
Interventions
Epic 10 Diode Laser by Biolase Inc., Placebo
Device · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
6 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Sep 29, 2026, 4:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Class II Correction Study Using the Invisalign System

NCT02376829
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign System
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
11 Years to 19 Years
Enrollment
164 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
8
States / cities
Scottsdale, Arizona • Rocklin, California • Roseville, California + 5 more
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 29, 2026, 4:49 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effect of OrthoPulse™ Photobiomodulation on Tooth Movement and Treatment Time When Used With Invisalign Treatment

NCT02954133
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign (7 day), Invisalign (5 day), OrthoPulse, Invisalign (3.5 day)
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
4
States / cities
Chandler, Arizona • Maple Grove, Minnesota • Henderson, Nevada + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Sep 29, 2026, 4:49 PM EDT