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ClinicalTrials.gov public records Last synced Oct 17, 2026, 7:45 PM EDT

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Showing 1–24 of 40 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Orthodontics Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions

NCT03440996
View directory record Official record
Conditions
White Spot Lesion, Orthodontic Treatment, Decalcification; Teeth
Interventions
Clinpro™ 5000, Clinpro™ Tooth Crème, MI-Paste Plus
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 17, 2026, 7:45 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Impact of Increased Body Mass Index on Adolescent Fixed Orthodontic Treatment. A Prospective Longitudinal Study

NCT07217756
View directory record Official record
Conditions
Obesity & Overweight, Orthodontic Treatment
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
12 Years to 18 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 17, 2026, 7:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effect of OrthoPulse™ Photobiomodulation on Tooth Movement and Treatment Time When Used With Invisalign Treatment

NCT02954133
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign (7 day), Invisalign (5 day), OrthoPulse, Invisalign (3.5 day)
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
4
States / cities
Chandler, Arizona • Maple Grove, Minnesota • Henderson, Nevada + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

Effect of Intra-Oral Photobiomodulation on Orthodontic Treatment Time

NCT02267850
View directory record Official record
Conditions
Malocclusion
Interventions
Fixed Orthodontic Appliance Treatment, OrthoPulse™, Non-Functional OrthoPulse™
Other · Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
12 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 21, 2018 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Class II Correction Study Using the Invisalign System

NCT02376829
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign System
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
11 Years to 19 Years
Enrollment
164 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
8
States / cities
Scottsdale, Arizona • Rocklin, California • Roseville, California + 5 more
Source: ClinicalTrials.gov public record
Updated May 6, 2023 · Synced Oct 17, 2026, 7:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Precision Orthodontics: Virtual Treatment Planning for Orthodontic Braces

NCT04002999
View directory record Official record
Conditions
Malocclusion, Malocclusion, Angle's Class
Interventions
3D printed ceramic bracket and tray, Stock ceramic bracket + 3D printed tray, Stock bracket, no tray
Device
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
11 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

Alveolar Microperforation for Inflammation-Enhanced Tooth Movement During Orthodontic Treatment

NCT01720797
View directory record Official record
Conditions
Malocclusion
Interventions
Micro-osteoperforation, Anesthestic, Chlorhexidine
Device · Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 19, 2015 · Synced Oct 17, 2026, 7:45 PM EDT
Recruiting No phase listed Observational

Inflammation in Clear Aligners With and Without Attachments

NCT07506993
View directory record Official record
Conditions
Periodontal Inflammation
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
14 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 17, 2026, 7:45 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

The Effect of Tooth Position During Orthodontic Treatment on the Apnea/ Hypopnea Index (AHI)

NCT03299023
View directory record Official record
Conditions
Obstructive Sleep Apnea, Orthodontic Tooth Movement, Apnea, Sleep Disordered Breathing
Interventions
Medibyte Portable Monitor
Other
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
8 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Oct 17, 2026, 7:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

OrthoPulse 2.0 and 2.1 Feasibility Evaluation

NCT03683017
View directory record Official record
Conditions
Malocclusion
Interventions
OrthoPulse 2.0, OrthoPulse 2.1, Invisalign 3.5 Day Wear, Fixed Orthodontic Appliances (Braces)
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
6
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

The Effect of OrthoPulse™ on the Rate of Orthodontic Tooth Movement

NCT02267811
View directory record Official record
Conditions
Malocclusion
Interventions
Orthodontic Treatment, OrthoPulse™
Other · Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2019 · Synced Oct 17, 2026, 7:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances

NCT04186065
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Hiroko Nagaoka
Other
Eligibility
10 Years to 70 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 24, 2020 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pre-emptive Analgesics in Orthodontic Treatment

NCT03523988
View directory record Official record
Conditions
NSAID, Pain Management
Interventions
Acetaminophen, Ibuprofen
Drug
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 59 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners

NCT01962012
View directory record Official record
Conditions
Malocclusion
Interventions
AcceleDent Aura, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Oct 17, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Miniscrew Stability and Peri-implant Inflammation When Precoated K21 vs Ethanol Control

NCT05639907
View directory record Official record
Conditions
Inflammation Caused by the Placement of a Temporary Anchorage Device
Interventions
K21 Cavity cleanser, Ethanol control
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 17, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive

NCT07091422
View directory record Official record
Conditions
Bracket Bonding, Orthodontic Treatment, Dental Adhesives/Restorations Performance, White Spot Lesion of Tooth
Interventions
Etch-Free Adhesive, Conventional Etch-and-Bond Adhesive
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

OrthoPulse™ and Its Effect on the Rate of Orthodontic Tooth Alignment: A Pilot Feasibility Study

NCT02267837
View directory record Official record
Conditions
Malocclusion
Interventions
OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 17, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study of the Use of Orthopulse Photobiomodulation

NCT05650359
View directory record Official record
Conditions
Orthodontics
Interventions
OrthoPulse, No intervention
Device · Other
Lead sponsor
Biolux Technology GmbH
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chandler, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 7, 2024 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment

NCT02745626
View directory record Official record
Conditions
Orthodontic Pathological Resorption of External Root, Complication of Personal Oral Hygiene
Interventions
Appliance
Device
Lead sponsor
UConn Health
Other
Eligibility
12 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2017 · Synced Oct 17, 2026, 7:45 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances

NCT03202355
View directory record Official record
Conditions
Malocclusion
Interventions
Fixed Appliance Orthodontic Treatment, OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
3
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT Comparing Invisalign and Traditional Orthodontic Treatment

NCT04556448
View directory record Official record
Conditions
Malocclusion, Angle Class II
Interventions
Aligners, Clear braces
Other
Lead sponsor
Texas A&M University
Other
Eligibility
17 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 17, 2026, 7:45 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Topical 10% Povidone-Iodine in Preventing White Spots

NCT06616207
View directory record Official record
Conditions
White Spot Lesions, Gingival Inflammation and Bleeding
Interventions
Placebo, Povidone-iodine solution
Drug
Lead sponsor
University of Washington
Other
Eligibility
10 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 17, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

Accelerated Tooth Movement With AcceleDent® and Aligners - a Pilot Project

NCT02438280
View directory record Official record
Conditions
Tooth Movement, Malocclusion
Interventions
AcceleDent, Vibrational Device
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Oct 17, 2026, 7:45 PM EDT