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ClinicalTrials.gov public records Last synced Oct 4, 2026, 1:01 AM EDT

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Showing 1–24 of 83 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteo Arthritis of the Knee Clear all
Not listed Phase 4 Interventional

High Versus Low Adductor Canal Block

NCT04155983
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Ropivacaine
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2020 · Synced Oct 4, 2026, 1:01 AM EDT
Recruiting Not applicable Interventional

Gait Rehabilitation to Treat FastOA

NCT05848622
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee, Knee Injuries, Cartilage, Articular, Gait
Interventions
Real-time gait biofeedback, Sham real-time gait biofeedback
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 35 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 4, 2026, 1:01 AM EDT
Recruiting Phase 2 Interventional

An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint

NCT06485843
View directory record Official record
Conditions
Osteoarthritis, Osteo Arthritis Knee
Interventions
OA-SYS
Drug
Lead sponsor
Ageless Biotech, Inc.
Industry
Eligibility
35 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Oct 4, 2026, 1:01 AM EDT
Not listed Not applicable Interventional

Post-op Ketamine Study

NCT03865550
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Isotonic saline, Ketamine Injectable Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
Not listed
Enrollment
75 participants
Timeline
2016 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteoarthritis Care Tools for Primary Care Providers

NCT06988163
View directory record Official record
Conditions
Arthritis, Osteo Arthritis Knee
Interventions
OACareTools+
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 4, 2026, 1:01 AM EDT
Withdrawn Phase 2 Interventional

Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee

NCT03271229
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Concentrated Bone Marrow Aspirate (BMAC), Platelet-Rich Plasma (PRP)
Biological
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 24, 2019 · Synced Oct 4, 2026, 1:01 AM EDT
Withdrawn Not applicable Interventional

rTMS for Relieving Chronic OA Pain

NCT05097729
View directory record Official record
Conditions
Chronic Pain, Osteo Arthritis Knee
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 4, 2026, 1:01 AM EDT
Not listed Phase 4 Interventional

EXPAREL IPSA Block in Knee Arthroplasty

NCT06619340
View directory record Official record
Conditions
Pain, Postoperative, Osteo Arthritis Knee
Interventions
Exparel
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Phase 1 Interventional Results available

Melatonin Use After Primary Total Joint Arthroplasty

NCT04795336
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Melatonin 5 mg, Placebo
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 95 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Phase 3 Interventional

Microfragmented Adipose Tissue Compared to Corticosteroid Injection for the Treatment of Knee Osteoarthritis

NCT05660772
View directory record Official record
Conditions
Knee Osteoarthritis, Osteo Arthritis Knee
Interventions
Microfragmented Adipose Tissue, Corticosteroid
Device · Drug
Lead sponsor
Lipogems International spa
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
18
States / cities
Encinitas, California • Redwood City, California • Gulf Breeze, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 4, 2026, 1:01 AM EDT
Active, not recruiting Not applicable Interventional

Geniculate Artery Embolization for Osteoarthritis

NCT04456569
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis, Osteoarthritis, Osteoarthritis, Knee
Interventions
Geniculate Artery Embolization
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 4, 2026, 1:01 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals

NCT06701461
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Electrodermal Activity signal
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Self Cranial Electrical Stimulation (CES) for Pain in Older Adults With Knee Osteoarthritis (Self CES for Knee Pain)

NCT04016259
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cranial Electrical Stimulation (CES), Sham-CES
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
50 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee

NCT03028870
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
V120083, Naproxen, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
40 Years to 80 Years
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
30
States / cities
Birmingham, Alabama • Tuscumbia, Alabama • North Hollywood, California + 24 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2019 · Synced Oct 4, 2026, 1:01 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee Joint

NCT04750252
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
StroMel
Biological
Lead sponsor
Akan Biosciences, LLC
Industry
Eligibility
25 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Gaithersburg, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 4, 2026, 1:01 AM EDT
Recruiting Not applicable Interventional

Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)

NCT06058169
View directory record Official record
Conditions
Whole Body Vibration, Osteo Arthritis Knee
Interventions
Sub Acute Whole Body Vibration Training
Device
Lead sponsor
Augusta University
Other
Eligibility
40 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)

NCT03362957
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Geniculate Artery Embolization, Sham Procedure
Device · Diagnostic Test
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Woodbridge, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Oct 4, 2026, 1:01 AM EDT
Recruiting Not applicable Interventional

MISHA Post-Market Clinical Study

NCT06118892
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
MISHA Knee System
Device
Lead sponsor
Moximed
Industry
Eligibility
25 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
4
States / cities
Sonoma, California • Raleigh, North Carolina • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty

NCT03653416
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Ipack, Bupivacaine, Peri Articular Infiltration
Device · Drug · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty

NCT03395990
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Active comparator: chloroprocaine, Sham comparator: saline
Procedure
Lead sponsor
Duke University
Other
Eligibility
56 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Oct 4, 2026, 1:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes

NCT06734845
View directory record Official record
Conditions
Orthopedic, Osteo Arthritis Knee, Hip Osteoarthritis, Protein-Energy Malnutrition, Energy Malnutrition Protein
Interventions
Total Knee Arthroplasty, Total Joint Arthroplasty
Procedure
Lead sponsor
University of Connecticut
Other
Eligibility
50 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Oct 4, 2026, 1:01 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Pregabalin for Central Sensitization in TKA

NCT05460871
View directory record Official record
Conditions
Osteo Arthritis Knee, Central Nervous System Sensitization
Interventions
Pregabalin 75mg
Drug
Lead sponsor
University of Iowa
Other
Eligibility
50 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 4, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty

NCT04730271
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 4, 2026, 1:01 AM EDT
Not listed Not applicable Interventional

Trial of Unicompartmental Versus Total Knee Arthroplasty

NCT03385759
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Unicompartmental knee arthroplasty, Total knee arthroplasty
Procedure
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Alexandria, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 4, 2026, 1:01 AM EDT