Independent directory Public ClinicalTrials.gov records United States
Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 15, 2026, 5:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 505–528 of 1,212 matching trials from the live ClinicalTrials.gov search.
Conditions
Osteoarthritis, Knee
Interventions
Celecoxib, Naproxen, Placebo
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
40 Years and older
Enrollment
586 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
51
States / cities
Montgomery, Alabama • Phoenix, Arizona • Tempe, Arizona + 41 more
Completed No phase listed Observational

Antero-Posterior Knee Stability

NCT03387839
Conditions
Osteoarthritis, Total Knee Arthroplasty, Stability, Knee Osteoarthritis
Interventions
Stress X-Ray
Other
Lead sponsor
David F. Scott, MD
Other
Eligibility
21 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Spokane, Washington
Conditions
Osteo Arthritis Knee
Interventions
Injection of Autologous Adipose Tissue, Injection of lactated ringers
Other
Lead sponsor
Aestique Medical Center
Other
Eligibility
40 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Greensburg, Pennsylvania
Completed Not applicable Interventional Results available

Knee Bracing for People With Patellofemoral Osteoarthritis

NCT00381563
Conditions
Knee Osteoarthritis
Interventions
Patellofemoral realigning knee brace, Non-aligning knee brace
Device
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Boston, Massachusetts
Conditions
Osteoarthritis, Knee
Interventions
UBX0101, Placebo
Drug · Other
Lead sponsor
Unity Biotechnology, Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
7
States / cities
El Cajon, California • La Mesa, California • Miami, Florida + 4 more
Conditions
Osteoarthritis, Osteo Arthritis Knee
Interventions
OA-SYS
Drug
Lead sponsor
Ageless Biotech, Inc.
Industry
Eligibility
35 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Las Vegas, Nevada
Conditions
Knee Osteoarthritis
Interventions
PEP/Euflexxa, PEP
Combination Product · Drug
Lead sponsor
Rion Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Conditions
Osteoarthritis, Pain
Interventions
Placebo, Fulranumab 1 mg, Fulranumab 3 mg
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
26
States / cities
Phoenix, Arizona • Costa Mesa, California • Laguna Hills, California + 23 more
Not yet recruiting Not applicable Interventional

Boosting Exercise Adherence in Knee Osteoarthritis

NCT07219732
Conditions
Osteoarthritis, Knee
Interventions
Usual PT Care (UC), BOOST-OA
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Knee Osteoarthritis
Interventions
Kenalog with bupivacaine Injection
Drug
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tampa, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

Heel Wedges and Carbon Fiber Custom Dynamic Orthoses to Control Knee Biomechanics

NCT05209360
Conditions
Adult ALL, Healthy
Interventions
Medial or Lateral Wedge, Carbon Fiber Custom Dynamic Orthosis
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Iowa City, Iowa
Conditions
Osteoarthritis of Knee, Edema, Wounds and Injuries
Interventions
ODIN1, Standard Care, Diagnostic Device Testing
Device · Other
Lead sponsor
Bioelectric Research Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Las Vegas, Nevada
Conditions
Knee Osteoarthritis
Interventions
Implementation Strategy: Foundational Arm, Implementation Strategy: REACH Arm
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Osteoarthritis (OA) of the Knee, Fracture, Rheumatoid Arthritis
Interventions
total knee arthroplasty device
Device
Lead sponsor
LinkBio Corp.
Industry
Eligibility
18 Years to 79 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
2
States / cities
Birmingham, Alabama • Libertyville, Illinois
Conditions
Primary Knee Osteoarthritis
Interventions
Allocetra, Placebo
Drug · Other
Lead sponsor
Enlivex Therapeutics Ltd.
Industry
Eligibility
64 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Longwood, Florida • Miami, Florida • New Orleans, Louisiana + 1 more
Conditions
Osteoarthritis
Interventions
KBA exercise, strength training exercise, KBA and strength training, Control group
Other
Lead sponsor
University of Zululand
Other
Eligibility
50 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
St. Petersburg, Florida
Conditions
Pain Associated With Osteoarthritis of the Knee
Interventions
X0002
Drug
Lead sponsor
Techfields Pharma Co. Ltd
Industry
Eligibility
35 Years to 85 Years
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
33
States / cities
Phoenix, Arizona • Yuma, Arizona • Anaheim, California + 29 more
Enrolling by invitation Not applicable Interventional

Cemented vs. Cementless Unicompartmental Knee Arthroplasty

NCT05616884
Conditions
Partial Knee Replacement
Interventions
Cementless fixation
Procedure
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Alexandria, Virginia
Conditions
Knee Osteoarthritis, Obese, Depression
Interventions
Fisetin, GetHealthy-OA mind-body program, Placebo oral capsule, Health education booklet
Drug · Behavioral
Lead sponsor
Cale Andrew Jacobs, PhD
Other
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
Lexington, Kentucky
Conditions
Hip Osteoarthritis, Knee Osteoarthritis
Interventions
Brief interactive decision aid, Long video decision aid
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Newton, Massachusetts
Conditions
Knee Osteoarthritis
Interventions
Optimized Tai Chi intervention, Traditional Tai Chi intervention
Behavioral
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
40 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Conditions
Osteoarthritis of the Knee
Interventions
OLT1177 Gel, Placebo gel
Drug · Other
Lead sponsor
Olatec Therapeutics, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
3
States / cities
DeLand, Florida • South Miami, Florida • Raleigh, North Carolina
Conditions
Rheumatoid Arthritis, Traumatic Arthritis, Joint Disease Secondary to Osteoarthritis
Interventions
Encore 3DKnee™ system, Encore MJS™ Knee System
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fresno, California
Conditions
Knee Osteoarthritis
Interventions
focus motion knee brace
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
95 participants
Timeline
2022 – 2028
U.S. locations
1
States / cities
St Louis, Missouri