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ClinicalTrials.gov public records Last synced Oct 7, 2026, 4:06 AM EDT

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Showing 49–72 of 480 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis Knee Pain Clear all
Completed Phase 2 Interventional

Muscle Strengthening Device for Knee Osteoarthritis

NCT00007241
View directory record Official record
Conditions
Osteoarthritis
Interventions
Isometric exercise
Device
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
6
States / cities
Trumbull, Connecticut • Moorestown, New Jersey • Rochester, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2007 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Not applicable Interventional

ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA)

NCT04497129
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Disease, Joint Pain, Osteo Arthritis Knee, Osteoarthritis, Knee
Interventions
ROMTech PortableConnect, Traditional Rehabilitation and CPM Device
Device
Lead sponsor
ROM Technologies, INC
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
Gilbert, Arizona • Aventura, Florida • Clearwater, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 7, 2026, 4:06 AM EDT
Active, not recruiting No phase listed Interventional Results available

Effects of tDCS and tUS on Pain Perception in OA of the Knee

NCT02723929
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
active low-intensity transcranial electrical stimulation/active transcranial ultrasound, Sham low-intensity transcranial electrical stimulation/sham transcranial ultrasound
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 7, 2026, 4:06 AM EDT
Active, not recruiting Not applicable Interventional

Pain & Aging: Combined Interventions for Fitness in the Community Study

NCT04099394
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Behavioral Health, Health Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
65 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 7, 2026, 4:06 AM EDT
Recruiting Not applicable Interventional

Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

NCT03711773
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Ankle
Interventions
Group Physical Therapy Classes
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

ROSA Robot Used in Total Knee Replacement Post Market Study

NCT03969654
View directory record Official record
Conditions
Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis
Interventions
PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
5
States / cities
Vail, Colorado • Westminster, Colorado • Springfield, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 3 Interventional Results available

Duloxetine Versus Placebo for Osteoarthritis Knee Pain

NCT00408421
View directory record Official record
Conditions
Osteoarthritis Knee Pain
Interventions
Duloxetine, placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
21
States / cities
Chandler, Arizona • Beverly Hills, California • Northridge, California + 18 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Not applicable Interventional

Acupuncture for Pain and Sleep Disturbance in Knee Osteoarthritis

NCT00694447
View directory record Official record
Conditions
Sleep, Pain
Interventions
Acupuncture
Procedure
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2013 · Synced Oct 7, 2026, 4:06 AM EDT
Withdrawn Phase 4 Interventional

The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

NCT06489626
View directory record Official record
Conditions
Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative
Interventions
Methylprednisolone 4 milligram Tab, Dexamethasone injection
Drug
Lead sponsor
F. Johannes Plate
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 2 Interventional Results available

A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control

NCT03528369
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain
Interventions
CGS-200-1, CGS-200-5, CGS-200 Vehicle
Drug
Lead sponsor
Propella Therapeutics
Industry
Eligibility
35 Years to 75 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
6
States / cities
Clearwater, Florida • Tampa, Florida • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Oct 7, 2026, 4:06 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

NCT02607579
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
Monmouth Medical Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Long Branch, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Oct 7, 2026, 4:06 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

The Safety and Efficacy of XytriX (Umbilical Cord-Derived Mesenchymal Stem Cells) in the Treatment of Knee Osteoarthritis

NCT07487766
View directory record Official record
Conditions
Osteoarthritis
Interventions
Mesenchymal Stem Cell Injection
Biological
Lead sponsor
TricelX Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 7, 2026, 4:06 AM EDT
Withdrawn Not applicable Interventional

Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators

NCT03664466
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
astaxanthin, Placebo
Dietary Supplement · Other
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Oct 7, 2026, 4:06 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty

NCT02341079
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Arthritis, Degenerative, Osteoarthrosis, Osteoarthrosis Deformans
Interventions
Bupivacaine Liposome Injection, Indwelling femoral nerve block
Drug
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2017 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 2 Interventional Results available

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee

NCT00689273
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
PF-04136309, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
18
States / cities
DeLand, Florida • South Miami, Florida • Overland Park, Kansas + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 7, 2026, 4:06 AM EDT
Not listed Not applicable Interventional

Effectiveness of a Walking Intervention on Impact Loading and Pain

NCT04148807
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Pain Chronic
Interventions
Progressive Walking with Gait Retraining, Progressive Walking Program
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
45 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 2 Interventional

A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee

NCT01444365
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ABT-652 NSAID, Placebo NSAID
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
40 Years to 75 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
31
States / cities
Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 27 more
Source: ClinicalTrials.gov public record
Updated May 15, 2013 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 2 Interventional Results available

Investigation of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee

NCT02958267
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
BMAC injection, PRP injection, Gel-One® hyaluronate injection
Biological · Device
Lead sponsor
OhioHealth
Other
Eligibility
40 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Not applicable Interventional Results available

Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA

NCT02730728
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Post Operative Pain Control
Interventions
20ml bolus of 0.5% ropivicaine, 0.2% Ropivicaine at 8 milliliter/hour, 5ml bolus of 0.5% ropivicaine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 2 Interventional

HKT-500-US12 In Adult Patients With OA Knee Pain

NCT00647231
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
HKT-500 Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
45 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2015 · Synced Oct 7, 2026, 4:06 AM EDT
Recruiting Phase 2 Interventional

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

NCT06884865
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Enekinragene Inzadenovec (PCRX-201), Placebo
Biological
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
45 Years to 80 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
40
States / cities
Birmingham, Alabama • Phoenix, Arizona • Beverly Hills, California + 34 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 7, 2026, 4:06 AM EDT
Withdrawn No phase listed Observational

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

NCT03893292
View directory record Official record
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 7, 2026, 4:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial for Partial Knee Arthroplasty

NCT05037734
View directory record Official record
Conditions
Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity, Knee Pain Chronic
Interventions
Persona Partial Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 7, 2026, 4:06 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis

NCT00426621
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Diclofenac Sodium Gel, Placebo
Drug
Lead sponsor
Novartis
Industry
Eligibility
35 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
64
States / cities
Mobile, Alabama • Tallassee, Alabama • Chandler, Arizona + 59 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2007 · Synced Oct 7, 2026, 4:06 AM EDT