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ClinicalTrials.gov public records Last synced Oct 3, 2026, 10:25 AM EDT

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Showing 73–96 of 1,073 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis of the Knee Clear all
Completed Not applicable Interventional Results available

Tai Chi and Physical Therapy for Knee Osteoarthritis

NCT01258985
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Tai Chi, Physical Therapy
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
40 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2016 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Phase 1Phase 2 Interventional

Gait Retraining to Reduce Knee Osteoarthritis Pain

NCT01397981
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Gait retraining
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2013 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Phase 3 Interventional

Microfragmented Adipose Tissue Compared to Corticosteroid Injection for the Treatment of Knee Osteoarthritis

NCT05660772
View directory record Official record
Conditions
Knee Osteoarthritis, Osteo Arthritis Knee
Interventions
Microfragmented Adipose Tissue, Corticosteroid
Device · Drug
Lead sponsor
Lipogems International spa
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
18
States / cities
Encinitas, California • Redwood City, California • Gulf Breeze, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Phase 3 Interventional Results available

Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)

NCT03818737
View directory record Official record
Conditions
Osteoarthritis
Interventions
Bone Marrow Derived MSCs, Adipose-derived MSCs, Umbilical Cord Tissue (UCT) MSCs, Corticosteroid injection
Biological · Drug
Lead sponsor
Emory University
Other
Eligibility
40 Years to 70 Years
Enrollment
475 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
5
States / cities
Gulf Breeze, Florida • Atlanta, Georgia • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Not applicable Interventional Results available

Educational Intervention for Knee Pain

NCT00324857
View directory record Official record
Conditions
Osteoarthritis
Interventions
Decision Aid Video, Motivational Interviewing, MI plus Decision aid, Attention control
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
663 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
3
States / cities
Cleveland, Ohio • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Oct 3, 2026, 10:25 AM EDT
Terminated Phase 3 Interventional Results available

Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study

NCT01089725
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Pain
Interventions
Placebo IV, Placebo SC, Tanezumab SC, Tanezumab IV
Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
385 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
91
States / cities
Montgomery, Alabama • Mesa, Arizona • Phoenix, Arizona + 64 more
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Phase 1Phase 2 Interventional

A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee

NCT00944892
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
REGN475, Placebo
Drug · Other
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
40 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
3
States / cities
Anaheim, California • Tampa, Florida • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 8, 2011 · Synced Oct 3, 2026, 10:25 AM EDT
Recruiting Not applicable Interventional

Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

NCT07674901
View directory record Official record
Conditions
Knee Arthritis, Osteoarthritis
Interventions
Knee sleeve
Device
Lead sponsor
Margaret L Gourlay, MD, MPH
Other
Eligibility
50 Years to 64 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 3, 2026, 10:25 AM EDT
Not listed Phase 3 Interventional

A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty

NCT04298528
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Dronabinol, Placebo
Drug · Other
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
21 Years to 75 Years
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Oct 3, 2026, 10:25 AM EDT
Recruiting No phase listed Observational

Innovations in Genicular Outcomes Registry

NCT05495334
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Treatment for Knee OA
Procedure
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
Not listed
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2033
U.S. locations
19
States / cities
Phoenix, Arizona • Irvine, California • Los Angeles, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Not applicable Interventional Results available

Combined Application of Electrical Stimulated Antagonist Contraction During Walking (Walking Study)

NCT02730598
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Hybrid Training System (HTS), Sensory TENS
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
39 Years to 70 Years · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 3, 2026, 10:25 AM EDT
Recruiting Phase 4 Interventional

Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty

NCT07775248
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Grosse Pointe Farms, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 3, 2026, 10:25 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Blood-Flow Restriction Exercise Following a Knee Replacement

NCT04018638
View directory record Official record
Conditions
Knee Injuries, Knee Osteoarthritis, Knee Arthritis
Interventions
B-FREE
Other
Lead sponsor
Michigan Technological University
Other
Eligibility
40 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Houghton, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 3, 2026, 10:25 AM EDT
Completed No phase listed Observational

Do Knee Injections Offer Benefit With Knee Arthritis Pain

NCT04017949
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Corticosteroid injection
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 3, 2026, 10:25 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multicenter Bone and Joint Health Study

NCT03033238
View directory record Official record
Conditions
Osteoarthritis,Knee
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
45 Years to 79 Years
Enrollment
4,185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2020
U.S. locations
3
States / cities
Birmingham, Alabama • Iowa City, Iowa • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Phase 2 Interventional

Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)

NCT00667654
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
CNTX-4975
Drug
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
40 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 6, 2016 · Synced Oct 3, 2026, 10:25 AM EDT
Not yet recruiting Not applicable Interventional

Ketogenic Diet to Reduce Osteoarthritis Pain in MCI

NCT07417891
View directory record Official record
Conditions
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis, Mild Cognitive Impairment, MCI, Mild Cognitive Impairment (MCI), Dementia
Interventions
Well-formulated ketogenic diet
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
55 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fairway, Kansas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Not applicable Interventional Results available

OA Clinic-Community CARE Model

NCT05349500
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Overweight, Obesity, Physical Inactivity, Weight Loss
Interventions
OA CARE Intervention, Usual Care control group
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Oct 3, 2026, 10:25 AM EDT
Recruiting Phase 2 Interventional

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

NCT06859164
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Interventions
Genicular Artery Embolization, Lipiodol, Simple angiogram
Procedure · Device
Lead sponsor
University of Chicago
Other
Eligibility
40 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 3, 2026, 10:25 AM EDT
Terminated Not applicable Interventional

PB125, Osteoarthritis, Pain, Mobility, and Energetics

NCT04638387
View directory record Official record
Conditions
Osteoarthritis, Knee, Muscle Weakness, Pain, Joint
Interventions
PB125, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
50 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Oct 3, 2026, 10:25 AM EDT
Active, not recruiting Phase 1 Interventional

Study to Evaluate the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee

NCT04119687
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
FX201
Biological
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
30 Years to 80 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
6
States / cities
Phoenix, Arizona • Sarasota, Florida • Kansas City, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Not applicable Interventional

The Kaia Hip and Knee Pain Intervention for Self-management of the Pain in Patients With Osteoarthritis.

NCT04615377
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Kaia hip and knee pain application, Treatment as usual
Behavioral · Other
Lead sponsor
Kaia Health Software
Industry
Eligibility
22 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 16, 2022 · Synced Oct 3, 2026, 10:25 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Bracing on Knee Osteoarthritis (OA)

NCT01886144
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Knee OA Brace
Device
Lead sponsor
Stony Brook University
Other
Eligibility
35 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2014 · Synced Oct 3, 2026, 10:25 AM EDT
Completed Not applicable Interventional Results available

Tai Chi Mind-Body Therapy for Knee Osteoarthritis

NCT00362453
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Tai Chi versus Attention Control
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
55 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 3, 2026, 10:25 AM EDT