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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Conditions
Opioid Overdose, Opiate Overdose
Interventions
Nalmefene Injection, Naloxone Injection
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Conditions
Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse, Drug Abuse in Pregnancy, Drug Addiction
Interventions
Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
Behavioral
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
6
States / cities
Jacksonville, Florida • Pittsburgh, Pennsylvania • Charleston, South Carolina + 3 more
Recruiting No phase listed Observational

Assessment of Methadone Dose Taken

NCT05981573
Conditions
Methadone Toxicity, Methadone Overdose, Pain, Chronic, Drug Metabolism, Poor, CYP2D6-Related, Metabolism Medication Toxicity
Interventions
Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo, Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo, ISF Extraction Device 2
Diagnostic Test · Drug · Device
Lead sponsor
Cari Health Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Lemon Grove, California
Completed No phase listed Observational Accepts healthy volunteers

Patient Reported Outcomes for Opioid Use Disorder

NCT03985163
Conditions
Opioid-use Disorder, Overdose of Opiate, Patient Participation
Interventions
Patient Reported Outcomes Electronic Survey
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Conditions
Occupational Health
Interventions
Stress First Aid (SFA)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 100 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Austin, Texas
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

NCT07179614
Conditions
Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
Interventions
Overdose Prevention Intervention Package (OPIP)
Behavioral
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Lexington, Kentucky
Conditions
Opioid Overdose
Interventions
Nalmefene HCl injection, Naloxone HCl intranasal
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Opioid Overdose, Substance Use Disorders
Interventions
Not listed
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Elmhurst, New York • New York, New York
Conditions
Opioid-use Disorder
Interventions
Recovery Initiation and Management after Overdose (RIMO), Passive Referral to Treatment Control
Behavioral · Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
Interventions
Community Paramedic Standard of Care (CP SOC), CROSSROADS
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
Miami, Florida • Boston, Massachusetts • Durham, North Carolina + 1 more
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Permanent Supportive Housing Overdose Prevention

NCT05786222
Conditions
Overdose
Interventions
CSH-Delivered Overdose Prevention Support
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
1,350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Conditions
Overdose, Substance Use
Interventions
TA Intervention
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
2,940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
New York, New York
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking

NCT07264582
Conditions
HIV Testing, STI, HCV, Overdose, Drug
Interventions
Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Conditions
Caregiver, Patient
Interventions
Survey Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Houston, Texas
Recruiting Not applicable Interventional

Families Left Behind

NCT06854757
Conditions
Grief, Grief Disorder, Prolonged, Overdose Accidental, Substance Use Disorders
Interventions
RIVER, Enhanced care as usual
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
4
States / cities
Birmingham, Alabama • San Diego, California • Farmington, Connecticut + 1 more
Completed Not applicable Interventional Results available

Evaluation of a Computerized Opioid Overdose Prevention Program

NCT02040077
Conditions
Computer + Fluency, Computer Only, Treatment as Usual
Interventions
Computer + Fluency, Computer Only, Treatment as Usual
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Opioid Overdose, Drug Overdose
Interventions
PROVIDENT
Behavioral
Lead sponsor
Brown University
Other
Eligibility
Not listed
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Overdose
Interventions
Peer Education, Narcan Nasal Product
Behavioral · Drug
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
614 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Opioid Use, Cognitive Change, Opioid-use Disorder
Interventions
CogMed
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Recruiting No phase listed Observational Accepts healthy volunteers

Emergency Medicine Peer Outreach Worker Engagement for Recovery

NCT06320015
Conditions
Substance Use Disorders, Overdose, Opioid Use Disorder, Alcohol Use Disorder
Interventions
Substance Misuse Assistance Response Team (SMART), Usual Care Group
Behavioral · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Opioid Dependence, Opioid Use Disorder
Interventions
Naloxone Education Intervention
Other
Lead sponsor
Edward Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Naperville, Illinois
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Opioid Overdose Mortality in the United States

NCT03924505
Conditions
Opioid Overdose
Interventions
Organize and Mobilize for Implementation Effectiveness, Dissemination
Other
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Berkeley, California
Conditions
Opiate Abuse, Opiate Overdose, Opioid-use Disorder
Interventions
Peer Addiction Counseling
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Greenville, South Carolina
Conditions
Opioid-use Disorder
Interventions
Case management
Behavioral
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 99 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Denver, Colorado