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Showing 1–24 of 570 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: PAD - Peripheral Arterial Disease Clear all
Recruiting Not applicable Interventional

Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease

NCT06182397
View directory record Official record
Conditions
Arterial Disease of Legs, Below-the-knee Obstruction, PAD - Peripheral Arterial Disease
Interventions
MagicTouch PTA Sirolimus drug coated balloon, Placebo balloon angioplasty
Device
Lead sponsor
Concept Medical Inc.
Industry
Eligibility
21 Years and older
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
29
States / cities
Scottsdale, Arizona • Los Angeles, California • Clearwater, Florida + 22 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Early Phase 1 Interventional

Chelation Therapy in Diabetic Patients With Critical Limb Ischemia

NCT03424746
View directory record Official record
Conditions
Critical Limb Ischemia, Peripheral Arterial Disease
Interventions
disodium EDTA
Drug
Lead sponsor
Mt. Sinai Medical Center, Miami
Other
Eligibility
50 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Miami Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jun 9, 2019 · Synced Jun 7, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional

Red Light Treatment in Peripheral Artery Disease

NCT03203239
View directory record Official record
Conditions
Peripheral Artery Disease, Claudication, Intermittent, Vasodilation
Interventions
Red Light (670 nm energy), Octafluoropropane
Device · Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Safety and Efficacy of K-134 for the Treatment of Intermittent Claudication

NCT00783081
View directory record Official record
Conditions
Intermittent Claudication
Interventions
K-134, Cilostazol 100 mg BID, Placebo
Drug
Lead sponsor
Kowa Research Institute, Inc.
Industry
Eligibility
40 Years and older
Enrollment
387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
30
States / cities
Tucson, Arizona • Little Rock, Arkansas • Beverly Hills, California + 27 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2012 · Synced Jun 7, 2026, 7:59 AM EDT
Active, not recruiting Not applicable Interventional Results available

LIFE-BTK PK Sub-study

NCT05208905
View directory record Official record
Conditions
Critical Limb Ischemia (CLI)
Interventions
Esprit BTK Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
3
States / cities
Jacksonville, Florida • South Dartmouth, Massachusetts • Bartlesville, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jun 7, 2026, 7:59 AM EDT
Not yet recruiting Not applicable Interventional

Shortwave Diathermy In-home Treatment for Indianapolis VA-only Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy

NCT07336381
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Neuropathy
Interventions
Replexa shortwave diathermy
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 7, 2026, 7:59 AM EDT
Recruiting No phase listed Observational

PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

NCT06567795
View directory record Official record
Conditions
Diabetes Mellitus Type 2, Cardiovascular Diseases, Coronary Artery Disease, Cerebrovascular Disease, Peripheral Artery Disease
Interventions
Hemotag
Device
Lead sponsor
Aventusoft, LLC.
Industry
Eligibility
40 Years and older
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Jun 7, 2026, 7:59 AM EDT
Active, not recruiting Not applicable Interventional Results available

LIFE-BTK Randomized Controlled Trial

NCT04227899
View directory record Official record
Conditions
Critical Limb Ischemia (CLI)
Interventions
Esprit BTK Device, Percutaneous Transluminal Angioplasty (PTA) Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
261 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
43
States / cities
Gilbert, Arizona • Little Rock, Arkansas • Deer Park, California + 36 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jun 7, 2026, 7:59 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

NCT06319339
View directory record Official record
Conditions
Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
Interventions
Vumerity, Placebo
Drug · Other
Lead sponsor
University of Nebraska
Other
Eligibility
50 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jun 7, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional

Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients

NCT05830721
View directory record Official record
Conditions
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
Interventions
MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
Device · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Phase 3 Interventional Results available

Antiplatelet Strategy for Peripheral Arterial Interventions for Revascularization of Lower Extremities

NCT02217501
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Clopidogrel, Acetylsalicylic acid (ASA)
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
4
States / cities
Denver, Colorado • Davenport, Iowa • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia

NCT00721006
View directory record Official record
Conditions
Critical Limb Ischemia, Severe Leg Ischemia, Peripheral Artery Disease, Peripheral Vascular Disease
Interventions
MESENDO, Placebo
Biological
Lead sponsor
TCA Cellular Therapy
Industry
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Covington, Louisiana
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Jun 7, 2026, 7:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease

NCT00380185
View directory record Official record
Conditions
Peripheral Vascular Diseases
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
40 Years and older
Enrollment
1,789 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2004
U.S. locations
2
States / cities
Stanford, California • New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Motivational Interviewing (MI) for African Americans With Peripheral Arterial Disease (PAD) Pilot

NCT01332058
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Motivational Interviewing
Behavioral
Lead sponsor
Tracie Collins, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2012 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Activity To Improve Outcomes in Peripheral Arterial Disease

NCT02189018
View directory record Official record
Conditions
Peripheral Arterial Occlusive Disease
Interventions
Active Exercise, Neuromuscular electrical stimulation, Weight loss and active exercise, Ad lib activity at home
Other
Lead sponsor
Baltimore VA Medical Center
Federal
Eligibility
21 Years to 90 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Comprehensive Magnetic Resonance of Peripheral Arterial Disease

NCT00587678
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Simvastatin, Ezetimibe, Simvastatin/Ezetimibe
Drug
Lead sponsor
University of Virginia
Other
Eligibility
30 Years to 85 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 20, 2017 · Synced Jun 7, 2026, 7:59 AM EDT
Terminated Phase 4 Interventional Results available

Cilostazol After Lower Extremity Arterial Revascularization Trial

NCT02374957
View directory record Official record
Conditions
Peripheral Arterial Disease, Claudication (Finding)
Interventions
Cilostazol
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
35 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 22, 2018 · Synced Jun 7, 2026, 7:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Validation of a Novel Oscillometric-Based Algorithm for Determination of the Ankle-Brachial Index

NCT01165437
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Blood Pressure Measurement
Device
Lead sponsor
Summit Doppler Systems, Inc.
Industry
Eligibility
50 Years and older
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 23, 2011 · Synced Jun 7, 2026, 7:59 AM EDT
Terminated No phase listed Observational

Short-term Perfusion Angiography Pilot Study (SPA)

NCT03054636
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Not listed
Lead sponsor
Volcano Corporation
Industry
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
4
States / cities
Miami, Florida • Wyoming, Michigan • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2020 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Phase 3 Interventional

Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease

NCT00059657
View directory record Official record
Conditions
Peripheral Vascular Disease
Interventions
Ecraprost in lipid emulsion
Drug
Lead sponsor
Tanabe Pharma Corporation
Industry
Eligibility
40 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
15
States / cities
Phoenix, Arizona • Tucson, Arizona • Glendale, California + 12 more
Source: ClinicalTrials.gov public record
Updated May 18, 2006 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

In-Stent Restenosis Post-Approval Study

NCT02542267
View directory record Official record
Conditions
Peripheral Artery Disease, Vascular Disease
Interventions
Gore VIABAHN Endoprosthesis
Device
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
20
States / cities
Miami, Florida • Honolulu, Hawaii • Rockford, Illinois + 16 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Phase 2 Interventional Results available

OHI--Randomized Control Trial to Evaluate Efficacy, Acceptability, and Perception of Benefit of an Innovative Custom AFO

NCT02819011
View directory record Official record
Conditions
Accidental Falls, Fall Due to Loss of Equilibrium, High Risk of Falls Due to Mobility Limitation, Diabetes, Arthritis, Cancer, Peripheral Arterial Disease, Parkinson's Disease, End Stage Renal Failure on Dialysis
Interventions
MBB AFO, Control
Device · Other
Lead sponsor
Bijan Najafi, PhD
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Jun 7, 2026, 7:59 AM EDT
Withdrawn No phase listed Observational

Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)

NCT04059536
View directory record Official record
Conditions
Chronic Total Occlusion, Atherosclerosis, Coronary Artery Disease, Peripheral Artery Disease
Interventions
Roxwood Anchoring Catheters, Acetylsalicylic Acid, Heparin
Device · Drug
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
25 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
11
States / cities
Phoenix, Arizona • Gainesville, Florida • Hobart, Indiana + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Jun 7, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease

NCT00443287
View directory record Official record
Conditions
Intermittent Claudication
Interventions
ataciguat (HMR1766), placebo, cilostazol
Drug
Lead sponsor
Sanofi
Industry
Eligibility
40 Years and older
Enrollment
553 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Jun 7, 2026, 7:59 AM EDT