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ClinicalTrials.gov public records Last synced Oct 31, 2026, 7:09 AM EDT

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Showing 217–240 of 10,293 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PAIN Clear all
Recruiting Not applicable Interventional

Binaural Beats for Postoperative Pain and Anxiety Reduction

NCT07437469
View directory record Official record
Conditions
TKA, THA, Anxiety, Binaural Beats, Music Exposure, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Total Knee Replacement, Total Hip Replacement
Interventions
Binaural Beats Audio Intervention, Music of Choice
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 31, 2026, 7:09 AM EDT
Not yet recruiting Phase 2 Interventional

Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster Headache

NCT07714369
View directory record Official record
Conditions
Cluster Headache
Interventions
Zavegepant 20 mg
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 31, 2026, 7:09 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Nitrous Oxide as Treatment for Fibromyalgia

NCT05357066
View directory record Official record
Conditions
Fibromyalgia, Central Neuropathic Pain
Interventions
Nitrous oxide gas for inhalation, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 31, 2026, 7:09 AM EDT
Recruiting Phase 4 Interventional

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

NCT07316166
View directory record Official record
Conditions
Postoperative Pain Management
Interventions
Dexmedetomidine, Ropivacaine
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 31, 2026, 7:09 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Topical CBD for Musculoskeletal Pain

NCT05170451
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
CBD, Control
Drug · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 31, 2026, 7:09 AM EDT
Not listed Phase 1Phase 2 Interventional

Embolization for the Treatment of Pain Secondary to Adhesive Capsulitis

NCT03676829
View directory record Official record
Conditions
Frozen Shoulder, Adhesive Capsulitis
Interventions
Arterial Embolization of the Shoulder
Device
Lead sponsor
Vascular Institute of Virginia
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Woodbridge, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 21, 2018 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Phase 2 Interventional Results available

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee

NCT00689273
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
PF-04136309, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
18
States / cities
DeLand, Florida • South Miami, Florida • Overland Park, Kansas + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 31, 2026, 7:09 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Age-dependent Effects of Smoked and Oral Delta-9-THC

NCT05865470
View directory record Official record
Conditions
Pain, Abuse, Drug, Intoxication; Cannabinoids
Interventions
Cannabis, Dronabinol, Smoked Placebo, Oral Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Not applicable Interventional

A Trial Comparing Different Dosing Regimens of Morphine in Patients With Moderate to Severe Pain

NCT00293969
View directory record Official record
Conditions
Pain
Interventions
Morphine 0.1mg/kg versus morphine 0.15 mg/kg
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 20, 2006 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Phase 2 Interventional

Efficacy/Safety Study of ACTIQ® for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP)

NCT00236041
View directory record Official record
Conditions
Cancer, Breakthrough Pain
Interventions
ACTIQ®
Drug
Lead sponsor
Cephalon
Industry
Eligibility
3 Years to 15 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
30
States / cities
Little Rock, Arkansas • Los Angeles, California • Orange, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 9, 2014 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Not applicable Interventional

Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia

NCT01528566
View directory record Official record
Conditions
Osteoarthritis, Knee, Dementia
Interventions
Tai Chi, Attention control
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
60 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2012 · Synced Oct 31, 2026, 7:09 AM EDT
Recruiting Not applicable Interventional

TMS for Complex Regional Pain Syndrome

NCT03137472
View directory record Official record
Conditions
Complex Regional Pain Syndromes
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2028
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 31, 2026, 7:09 AM EDT
Recruiting Not applicable Interventional

Eastern Principles Acceptance and Commitment Therapy For Injury Prevention Among Nurses and Nursing Aides

NCT06813495
View directory record Official record
Conditions
Well-Being, Psychological, Work Injury, Musculoskeletal Pain, High Frequency Heart Rate Variability, Burnout, Mindfulness, Self-Compassion, Acceptance and Commitment Therapy, Heart Rate Variability
Interventions
Eastern Principles Acceptance and Commitment Therapy for Nurses and Nursing Aids (EPACT NNA), Acceptance and Commitment Therapy for Nurses and Nursing Aids (ACT NNA)
Behavioral
Lead sponsor
Bowling Green State University
Other
Eligibility
18 Years and older
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Bowling Green, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Not applicable Interventional

I-COPE Study: Opioid Use and Pain Management in Older Adults

NCT04878562
View directory record Official record
Conditions
Chronic Pain, Opioids, Opioid-use Disorder
Interventions
I-COPE
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
65 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Phase 3 Interventional

Use of a Dual-agent Local Analgesic (Bupivacaine-meloxicam) for Abdominal Incisions in Patients Undergoing Retropubic Mid-urethral Sling Surgery

NCT05702827
View directory record Official record
Conditions
Stress Urinary Incontinence, Surgical Incision, Pain Vulva
Interventions
Bupivacaine-Meloxicam
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 22, 2024 · Synced Oct 31, 2026, 7:09 AM EDT
Terminated Phase 3 Interventional Results available

Open-Label Safety and Tolerability of Oxymorphone IR and ER in Opioid Tolerant Pediatric Subjects

NCT00765856
View directory record Official record
Conditions
Chronic Pain
Interventions
Oxymorphone ER
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
6 Years to 17 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
13
States / cities
Little Rock, Arkansas • Stanford, California • Aurora, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)

NCT04203537
View directory record Official record
Conditions
Postsurgical Pain
Interventions
CA-008, Placebo
Drug
Lead sponsor
Concentric Analgesics
Industry
Eligibility
18 Years to 80 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
4
States / cities
Pasadena, California • Carrollton, Texas • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Oct 31, 2026, 7:09 AM EDT
Terminated Phase 2 Interventional Results available

Study to Assess the Efficacy, Safety, and Tolerability of ADL5747 in Participants With Postherpetic Neuralgia

NCT01058642
View directory record Official record
Conditions
Postherpetic Neuralgia
Interventions
ADL5747, Placebo, Pregabalin
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 75 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 31, 2026, 7:09 AM EDT
Terminated Phase 3 Interventional Results available

Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

NCT05172570
View directory record Official record
Conditions
Thoracotomy, Pain, Postoperative
Interventions
Gabapentin
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 21, 2024 · Synced Oct 31, 2026, 7:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Dissecting the Heterogeneity of Oral Cancer Pain

NCT05024383
View directory record Official record
Conditions
Oral Squamous Cell Carcinoma
Interventions
Chemical sensitivity, Mechanical sensitivity
Other
Lead sponsor
NYU College of Dentistry
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Not applicable Interventional

Psychosocial Support for Acute Hospital Pain and Distress

NCT02590029
View directory record Official record
Conditions
Acute Pain
Interventions
Mindfulness, Suggestion, Psychoeducation
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Phase 3 Interventional Results available

Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children With Moderate to Severe Malignant and/ or Nonmalignant Pain Requiring Opioids

NCT01192295
View directory record Official record
Conditions
Pain
Interventions
Oxycodone HCl controlled-release tablets
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
6 Years to 16 Years
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
35
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 31 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Oct 31, 2026, 7:09 AM EDT
Terminated Phase 4 Interventional Results available

Study of Ranexa in Patients With Coronary Artery Disease and Painful Polyneuropathy

NCT00832572
View directory record Official record
Conditions
Coronary Artery Disease, Pain, Peripheral Nervous System Diseases, Polyneuropathy
Interventions
Ranolazine, Placebo
Drug
Lead sponsor
Gilead Sciences
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Houma, Louisiana
Source: ClinicalTrials.gov public record
Updated Jun 30, 2014 · Synced Oct 31, 2026, 7:09 AM EDT
Completed Phase 1 Interventional Results available

To Evaluate the Blockade of CGRP in Preventing PACAP-38 Induced Migraine-like Attacks With AMG 334 in Migraine Patients

NCT02542605
View directory record Official record
Conditions
Migraine
Interventions
Erenumab, Placebo, PACAP-38 Challenge Agent
Drug
Lead sponsor
Amgen
Industry
Eligibility
18 Years to 45 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Oct 31, 2026, 7:09 AM EDT