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ClinicalTrials.gov public records Last synced Oct 31, 2026, 1:08 PM EDT

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Showing 289–312 of 10,293 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PAIN Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Liposomal Bupivacaine Versus Interscalene Nerve Block

NCT03929146
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Exparel, Interscalene Nerve Block
Drug · Procedure
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Phase 4 Interventional Results available

Optimizing Local Anesthetic Concentration for Continuous Lumbar Plexus Nerve Blocks

NCT00912873
View directory record Official record
Conditions
Hip Arthroplasty, Hip Pain
Interventions
0.1% Ropivacaine, 0.4% Ropivacaine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Simultaneous mRNA COVID-19 and IIV4 Vaccination Study

NCT05028361
View directory record Official record
Conditions
Quality of Life, Injection Site Reaction, Adverse Drug Event, Systemic Reaction
Interventions
mRNA COVID-19, IIV4, Placebo (saline)
Biological · Other
Lead sponsor
Duke University
Other
Eligibility
5 Years and older
Enrollment
348 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
3
States / cities
Baltimore, Maryland • Durham, North Carolina • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Oct 31, 2026, 1:08 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Psorcast Mobile Study

NCT05621369
View directory record Official record
Conditions
Psoriatic Arthritis, Psoriasis, Psoriatic Conditions, Dermatologic Disease, Rheumatologic Disease, Psoriatic Nail, Plaque Psoriasis, Joint Pain, Dactylitis
Interventions
Participant self-assessment surveys, Psoriasis Draw, Psoriasis Area Photo, Finger and Toe Photos, Digital Jar Open, 30 Second Walk, Psorcast mobile application
Behavioral · Other
Lead sponsor
Sage Bionetworks
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Active, not recruiting Not applicable Interventional

An Internet-based Program to Help Cancer Survivors Manage Pain

NCT04462302
View directory record Official record
Conditions
Cancer
Interventions
Internet-based pain coping skills program
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
456 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
149
States / cities
Fort Smith, Arkansas • Antioch, California • Dublin, California + 118 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional

Pain Resilience Therapy for Low Back Pain.

NCT06971809
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
Pain resilience, Pain education
Behavioral
Lead sponsor
Integrative Pain Science Institute
Industry
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion

NCT03480009
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
Drug
Lead sponsor
Study Investigator-Sponsor
Other
Eligibility
18 Years and older · Female only
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2020 · Synced Oct 31, 2026, 1:08 PM EDT
Withdrawn Not applicable Interventional

Peripheral Nerve Responses to Focal Vibration and Implications in Pain and Mobility for Patients With Diabetic Peripheral Neuropathy

NCT05041816
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy
Interventions
Focal vibration therapy
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
45 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D2, Muscle Damage, NASCAR Pitcrew

NCT01825616
View directory record Official record
Conditions
Muscle Function, Muscle Soreness, Vitamin D Status
Interventions
Vitamin D2 mushroom powder, Placebo
Dietary Supplement · Other
Lead sponsor
Appalachian State University
Other
Eligibility
20 Years to 40 Years · Male only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
3
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2013 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Phase 3 Interventional Results available

Effectiveness, Safety, and Tolerability Study of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects

NCT01210352
View directory record Official record
Conditions
Post Operative Pain
Interventions
oxymorphone HCl
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
0 Years to 12 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
8
States / cities
Tucson, Arizona • Little Rock, Arkansas • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2021 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional

Acupuncture for Pain and Sleep Disturbance in Knee Osteoarthritis

NCT00694447
View directory record Official record
Conditions
Sleep, Pain
Interventions
Acupuncture
Procedure
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2013 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993

NCT06508762
View directory record Official record
Conditions
Pain
Interventions
VX-993
Drug
Lead sponsor
Vertex Pharmaceuticals Incorporated
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 10, 2024 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Phase 3 Interventional

Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)

NCT06004388
View directory record Official record
Conditions
Migraine, Episodic Migraine, Headache, Headache, Migraine
Interventions
Click Digital Therapeutic
Device
Lead sponsor
Click Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Oct 31, 2026, 1:08 PM EDT
Terminated Phase 2 Interventional

The Study Assessing the Safety and Efficacy of OK-101 Treatment in Subjects With Neuropathic Corneal Pain

NCT06637527
View directory record Official record
Conditions
Neuropathic Pain
Interventions
OK-101 0.05%, OK-101 0.1%, Placebo
Drug
Lead sponsor
Okyo Pharma Ltd
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional

Respiratory-Gated Vagal Nerve Stimulation for Chronic Pain

NCT04053127
View directory record Official record
Conditions
Chronic Pain
Interventions
RAVANS
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2022 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery

NCT02487303
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Acetaminophen Intravenous, Acetaminophen Oral
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Female only
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 5, 2018 · Synced Oct 31, 2026, 1:08 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Ice Versus EMLA for Pain in Laser Hair Removal

NCT02318654
View directory record Official record
Conditions
Hair Removal
Interventions
Ice Pack, Topical EMLA cream
Other · Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Not yet recruiting Phase 2 Interventional

Semaglutide for Low Back Pain

NCT07731256
View directory record Official record
Conditions
Lower Back Pain, Obesity (BMI>30), Chronic Lower Back Pain, glp1 Agonist
Interventions
Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
2
States / cities
Birmingham, Alabama • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Immediate Neuromuscular Responses of the Obliquus Capitis Inferior Following Upper Cervical Manual Therapy

NCT07725198
View directory record Official record
Conditions
Head and Neck, Headache
Interventions
Thrust long-axis manipulation of C1-C2
Other
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Fort Myers, Florida
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional Results available

Pain Outcomes Comparing Yoga Versus Structured Exercise (POYSE) Trial

NCT01797263
View directory record Official record
Conditions
Fibromyalgia
Interventions
Yoga, Structured Exercise
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional Results available

A Study To Evaluate Methods To Evaluate Back Pain

NCT01045993
View directory record Official record
Conditions
Pain
Interventions
Heat Device, Sham Device, marketed analgesic, Placebo
Device · Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2013 · Synced Oct 31, 2026, 1:08 PM EDT
Recruiting Not applicable Interventional

The Impact of Yoga on Endometriosis-Related Pain

NCT06559852
View directory record Official record
Conditions
Endometriosis
Interventions
Yoga
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional

Interscalene Catheter vs. Interscalene Liposomal Bupivacaine for Arthroscopic Rotator Cuff Repair

NCT04571606
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Single injection peripheral nerve block with liposomal bupivacaine (Exparel), Single injection peripheral nerve block with 0.25% bupivacaine and subsequent peripheral nerve catheter with 0.2% bupivacaine infusion via onQ pain pump
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 31, 2026, 1:08 PM EDT
Completed Not applicable Interventional

Telephone Intervention for Pain Study (TIPS)

NCT00663663
View directory record Official record
Conditions
Chronic Pain, Multiple Sclerosis, Amputation, Spinal Cord Injury
Interventions
Telephone-Delivered Intervention 1, Telephone-Delivered Intervention 2
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 30, 2013 · Synced Oct 31, 2026, 1:08 PM EDT