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ClinicalTrials.gov public records Last synced Nov 3, 2026, 2:31 PM EST

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Showing 625–648 of 10,295 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PAIN Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

NCT07222072
View directory record Official record
Conditions
Post Operative Pain, Spinal Surgery
Interventions
Methadone, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 72 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management During In-office Transcervical Sterilization

NCT02312739
View directory record Official record
Conditions
Contraception, Inhalation of Nitrous Oxide
Interventions
In-office Transcervical Sterilization (Essure®), Standard Oral pain medications, Intramuscular Ketorolac, Placebo pills, Oxygen, Nitrous Oxide
Procedure · Drug · Other
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 6, 2016 · Synced Nov 3, 2026, 2:31 PM EST
Completed Phase 3 Interventional Results available

Use of Perioperative Pain Blocks In Urological Surgery

NCT04426500
View directory record Official record
Conditions
Pain, Postoperative, Nerve Block, Robotic Surgical Procedures
Interventions
Bupivacain, Ultrasound-guided transversus abdominus plane block, Laparoscopic-guided transversus abdominus plane block
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Nov 3, 2026, 2:31 PM EST
Completed Phase 3 Interventional Results available

Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing

NCT01214811
View directory record Official record
Conditions
Inflammation, Burns, Ulcers
Interventions
Mepilex Border Ag
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
Momtgomery, Alabama • Iowa City, Iowa • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2013 · Synced Nov 3, 2026, 2:31 PM EST
Completed Phase 3 Interventional

Trial to Assess the Efficacy and Safety of SPM 927 (200, 400, and 600mg/Day) in Subjects With Painful Distal Diabetic Neuropathy

NCT00135109
View directory record Official record
Conditions
Diabetic Neuropathies
Interventions
SPM 927
Drug
Lead sponsor
UCB Pharma
Industry
Eligibility
18 Years and older
Enrollment
654 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
RTP, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2014 · Synced Nov 3, 2026, 2:31 PM EST
Active, not recruiting Not applicable Interventional

INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE

NCT06700109
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Neural Ice, Triamcinolone acetate
Device · Drug
Lead sponsor
Brixton Biosciences, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
15
States / cities
Larkspur, California • Washington D.C., District of Columbia • Gainesville, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional

Pain Resilience Therapy for Low Back Pain.

NCT06971809
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
Pain resilience, Pain education
Behavioral
Lead sponsor
Integrative Pain Science Institute
Industry
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Nov 3, 2026, 2:31 PM EST
Terminated Phase 2 Interventional Results available

Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy

NCT02062632
View directory record Official record
Conditions
Esophageal Carcinoma, Hypopharyngeal Carcinoma, Laryngeal Carcinoma, Lymphoma, Mesothelioma, Metastatic Malignant Neoplasm in the Lung, Metastatic Malignant Neoplasm in the Pleura, Metastatic Malignant Neoplasm in the Spinal Cord, Non-Small Cell Lung Carcinoma, Sarcoma, Small Cell Lung Carcinoma, Thymic Carcinoma, Thymoma, Thyroid Gland Carcinoma
Interventions
Doxepin Hydrochloride, Placebo, Quality-of-Life Assessment, Questionnaire Administration
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Rochester, Minnesota • Omaha, Nebraska • Green Bay, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Nov 3, 2026, 2:31 PM EST
Completed Phase 3 Interventional Results available

A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy

NCT04873232
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy
Interventions
Engensis, Placebo
Biological · Other
Lead sponsor
Helixmith Co., Ltd.
Industry
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Nov 3, 2026, 2:31 PM EST
Recruiting Not applicable Interventional

Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

NCT05176392
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Headache, Depression
Interventions
Active rTMS, Headache Management Therapy, Sham rTMS, Headache Education Control
Device · Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional Results available

Pain, Inflammation and Opioid Craving

NCT04190563
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Pain De-Catastrophizing, Pain Education
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Nov 3, 2026, 2:31 PM EST
Not yet recruiting Not applicable Interventional

Durability of Yoga for Veterans With Low Back Pain

NCT07053787
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Standard Yoga, Enhanced Yoga
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Nov 3, 2026, 2:31 PM EST
Completed Phase 3 Interventional Results available

A Phase 3 Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia

NCT04508621
View directory record Official record
Conditions
Fibromyalgia
Interventions
TNX-102 SL, Placebo SL Tablet
Drug
Lead sponsor
Tonix Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
36
States / cities
Birmingham, Alabama • Phoenix, Arizona • Oceanside, California + 33 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional Results available

PrEssure wiRe Compared to Microcatheter-based Sensing Technology For the Evaluation of FFR Measurements

NCT02648230
View directory record Official record
Conditions
Ischemia, Angina
Interventions
St. Jude Medical Pressure Wire, ACIST Navvus Microcatheter
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2019 · Synced Nov 3, 2026, 2:31 PM EST
Terminated Not applicable Interventional

Measuring Evoked Potentials From the Spinal Cord and Dorsal Root Ganglion

NCT03976219
View directory record Official record
Conditions
Neuropathic Pain
Interventions
ECAPS Closed Loop SCS
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Transversus Abdominis Plane Block

NCT06274307
View directory record Official record
Conditions
Anesthesia, Local
Interventions
Transversus abdominis plane block
Procedure
Lead sponsor
Justin Hruska
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Nov 3, 2026, 2:31 PM EST
Not listed Phase 4 Interventional

Dronabinol for Post-operative Pain After Lumbar Fusion

NCT04346407
View directory record Official record
Conditions
Post-operative Pain
Interventions
Dronabinol 2.5mg Cap, Placebo
Drug
Lead sponsor
Jeffrey L Gum MD
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 12, 2021 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lidocaine and Pain Management in First Trimester Abortions

NCT00613821
View directory record Official record
Conditions
Pain
Interventions
Lidocaine
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional

Opioid Use After Urogynecologic Procedures: Using a Predictive Calculator

NCT05571072
View directory record Official record
Conditions
Post Operative Pain, Opioid Use, Prolapse Genital
Interventions
Opioid calculator, Standard opioid prescription
Other
Lead sponsor
David Sheyn
Other
Eligibility
18 Years to 89 Years · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Nov 3, 2026, 2:31 PM EST
Active, not recruiting No phase listed Observational

Targeted Realtime Assessment of Chronic Pain in Youth

NCT06867757
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 24 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Nov 3, 2026, 2:31 PM EST
Not listed No phase listed Observational Accepts healthy volunteers

Subjective Observational Study of Patients Using Transdermal Cream Medication And/Or Transdermal Patches With Or Without Oral Non-Narcotic Medications

NCT03768011
View directory record Official record
Conditions
Pain, Chronic, Pain, Joint, Pain Syndrome
Interventions
transdermal cream and or patch
Combination Product
Lead sponsor
Data Collection Analysis Business Management
Other
Eligibility
18 Years to 64 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Land O' Lakes, Florida
Source: ClinicalTrials.gov public record
Updated Dec 7, 2018 · Synced Nov 3, 2026, 2:31 PM EST
Completed No phase listed Observational

Myofascial Pain and Central Sensitization

NCT04929171
View directory record Official record
Conditions
Myofascial Pain, Physical Therapy
Interventions
Physical Therapy
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Nov 3, 2026, 2:31 PM EST
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial for Partial Knee Arthroplasty

NCT05037734
View directory record Official record
Conditions
Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity, Knee Pain Chronic
Interventions
Persona Partial Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Nov 3, 2026, 2:31 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

A Care Management Intervention for Non-cardiac Chest Pain

NCT04904198
View directory record Official record
Conditions
Chest Pain
Interventions
Care Management Intervention for non-cardiac chest pain
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Nov 3, 2026, 2:31 PM EST