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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: PDA Clear all
Not listed Phase 3 Interventional

Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT

NCT05011149
View directory record Official record
Conditions
Patent Ductus Arteriosus After Premature Birth
Interventions
Ibuprofen
Drug
Lead sponsor
IWK Health Centre
Other
Eligibility
Up to 72 Hours
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Orange, California • San Diego, California • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Photodynamic Therapy for PDA in NV AMD

NCT02452840
View directory record Official record
Conditions
Neovascular Age-related Macular Degeneration, Macular Degeneration
Interventions
No Intervention
Other
Lead sponsor
Duke University
Other
Eligibility
50 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 8, 2021 · Synced Jul 21, 2026, 10:10 PM EDT
Active, not recruiting Phase 3 Interventional Results available

Management of the PDA Trial

NCT03456336
View directory record Official record
Conditions
Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth
Interventions
Active Treatment, Expectant Management
Other
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
48 Hours to 21 Days
Enrollment
482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
19
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus

NCT03551600
View directory record Official record
Conditions
Infant, Premature, Congenital Heart Disease, Patent Ductus Arteriosus, Necrotizing Enterocolitis
Interventions
Near-infrared spectroscopy (NIRS)
Procedure
Lead sponsor
University of Utah
Other
Eligibility
12 Days to 6 Months
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
3
States / cities
Murray, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Phase 2 Interventional Results available

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus

NCT01958320
View directory record Official record
Conditions
Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
Interventions
pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID
Other · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
5 Days to 14 Days
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
13
States / cities
San Diego, California • San Francisco, California • San Jose, California + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional

Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants

NCT01758913
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Ibuprofen
Drug
Lead sponsor
Taipei Medical University Hospital
Other
Eligibility
Up to 6 Months
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 2, 2013 · Synced Jul 21, 2026, 10:10 PM EDT
Recruiting Not applicable Interventional

Adaptive Radiation for Locally Advanced Unresectable Pancreatic Cancer

NCT06984562
View directory record Official record
Conditions
Locally Advanced Pancreatic Ductal Adenocarcinoma (PDA)
Interventions
Adaptive Radiation Therapy
Radiation
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional

Chest Shielding in Premature Infants During Phototherapy

NCT02552927
View directory record Official record
Conditions
Patent Ductus Arteriosus in Premature Infants
Interventions
Chest shield with aluminum foil (CALF), SHIELD
Device
Lead sponsor
University of Rochester
Other
Eligibility
23 Weeks to 33 Weeks
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Jul 21, 2026, 10:10 PM EDT
Recruiting Not applicable Interventional

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

NCT05547165
View directory record Official record
Conditions
Ductus Arteriosus, Patent
Interventions
Percutaneous Patent Ductus Arteriosus Closure (PPC), Responsive Management Intervention, Echocardiogram, cardiac
Device · Combination Product · Diagnostic Test
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
7 Days to 32 Days
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
24
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 19 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Timing for the Medical Treatment of Patent Ductus Arteriosus in Preterm Infants

NCT00795990
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
Up to 3 Months
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 4, 2014 · Synced Jul 21, 2026, 10:10 PM EDT
Terminated Not applicable Interventional Results available

Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure

NCT00833365
View directory record Official record
Conditions
Patent Ductus Arteriosus, Prematurity
Interventions
Ibuprofen
Drug
Lead sponsor
University of Utah
Other
Eligibility
Up to 96 Hours
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 3, 2016 · Synced Jul 21, 2026, 10:10 PM EDT
Terminated Not applicable Interventional Results available

RNA Precision Oncology in Advanced Pancreatic Cancer

NCT04476537
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
OncoTreat
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Jul 21, 2026, 10:10 PM EDT
Terminated Phase 4 Interventional

Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates

NCT00961753
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
optimized ibuprofen, Standard Ibuprofen
Drug
Lead sponsor
OSF Healthcare System
Other
Eligibility
1 Day to 29 Days
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 27, 2014 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Phase 1 Interventional

Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus

NCT03103022
View directory record Official record
Conditions
Patent Ductus Arteriosus, Neonate
Interventions
Acetaminophen, ibuprofen
Drug
Lead sponsor
University of Florida
Other
Eligibility
23 Weeks to 30 Weeks
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional

Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants

NCT00728117
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
feeding, fasting
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
23 Weeks to 33 Weeks
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
14
States / cities
San Francisco, California • San Jose, California • Chicago, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2012 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Nit-Occlud PDA Post-Approval Study

NCT02100683
View directory record Official record
Conditions
Patent Ductus Arteriosus (PDA)
Interventions
PDA Coil
Device
Lead sponsor
PFM Medical, Inc
Industry
Eligibility
6 Months to 21 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
11
States / cities
Loma Linda, California • Los Angeles, California • Madera, California + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional Results available

AMPLATZER Duct Occluder II Additional Sizes

NCT03055858
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
ADO II AS (PDA closure)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
3 Days and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
9
States / cities
Los Angeles, California • Orlando, Florida • Detroit, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Jul 21, 2026, 10:10 PM EDT
Withdrawn No phase listed Observational

Brain, Gut and Kidney Blood Flow During Medical Closure of PDA

NCT00554307
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
INVOS Cerebral/Somatic oximeter
Device
Lead sponsor
University of Louisville
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Lousiville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Treatment of a PDA With Acetaminophen in Preterm Neonates: Exploring Various Indications

NCT03289390
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Acetaminophen
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
23 Weeks to 30 Weeks
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Jul 21, 2026, 10:10 PM EDT
Withdrawn Not applicable Interventional

Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD

NCT02457026
View directory record Official record
Conditions
Neovascular Age-related Macular Degeneration
Interventions
Aflibercept, Triamcinolone Acetonide, Verteporfin
Drug
Lead sponsor
Duke University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional

NIT-OCCLUD PDA Phase II Sentinel Trial

NCT00828334
View directory record Official record
Conditions
Ductus Arteriosus, Patent
Interventions
Transcatheter PDA Coil
Device
Lead sponsor
PFM Medical, Inc
Industry
Eligibility
6 Months to 21 Years
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
15
States / cities
Los Angeles, California • Madera, California • Orange, California + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Phase 2 Interventional Results available

PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Participants With Stage IV Untreated Pancreatic Cancer

NCT01839487
View directory record Official record
Conditions
Metastatic Pancreatic Cancer
Interventions
PEGPH20, Nab-paclitaxel, Gemcitabine, Dexamethasone, Enoxaparin
Drug
Lead sponsor
Halozyme Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
279 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
51
States / cities
Birmingham, Alabama • Mobile, Alabama • Gilbert, Arizona + 45 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2020 · Synced Jul 21, 2026, 10:10 PM EDT
Terminated Not applicable Interventional Results available

Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants

NCT03982342
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Cather closure of patent ductus arteriosus (PDA), Conservative management of patent ductus arteriosus (PDA)
Device · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
14 Days to 28 Days
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Columbus, Ohio • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Phase 1 Interventional

Autologous Redirected RNA Meso CAR T Cells for Pancreatic Cancer

NCT01897415
View directory record Official record
Conditions
Subjects With Metastatic Pancreatic Ductal Adenocarcinoma (PDA)
Interventions
Autologous T cells transfected with chimeric anti-mesothelin immunoreceptor SS1
Biological
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Jul 21, 2026, 10:10 PM EDT