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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:49 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 1,843 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: POSTOPERATIVE PAIN Clear all

Conditions: Pain, Postoperative
Interventions: Single injection peripheral nerve block with liposomal bupivacaine (Exparel), Single injection peripheral nerve block with 0.25% bupivacaine and subsequent peripheral nerve catheter with 0.2% bupivacaine infusion via onQ pain pump; Procedure
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Pelvic Organ Prolapse, Abdominal Surgery, Laparoscopic Surgery, Post Operative Pain
Interventions: Abdominal binder; Device
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Thumb Basal Joint Osteoarthritis, Postoperative Pain, Joint Replacement Surgery, Joint Replacement
Interventions: suzetrigine 100mg, Acetaminophen; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 40 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 8 Years to 35 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Anesthesia, Dental, Pain, Postoperative
Interventions: lidocaine, articaine; Drug
Lead sponsor: Boston University; Other
Eligibility: 4 Years to 14 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Postoperative, Pelvic Organ Prolapse
Interventions: Ice T, Motrin/Percocet/Dilaudid for breakthrough; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years to 80 Years · Female only
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Surgery, Otolaryngologic Disorder, Pain, Postoperative
Interventions: Virtual Reality, Fitbit; Device
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
Interventions: IPACK, PLACEBO; Drug
Lead sponsor: Loyola University; Other
Eligibility: 16 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Anesthesia, Local, Pain, Postoperative
Interventions: Short-term ON-Q, Short-term ON-Q, Long-term ON-Q, Long-term ON-Q; Device · Drug
Lead sponsor: AdventHealth; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Thoracotomy, Pain, Postoperative
Interventions: Gabapentin; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Osteoarthritis
Interventions: Active Device (Torino II), Sham Device (Torino II); Device
Lead sponsor: Center for Joint Surgery and Sports Medicine, Maryland; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: Hagerstown, Maryland

Conditions: Pain
Interventions: Transcranial magnetic stimulation; Procedure
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: Not listed
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2002
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Kidney Stone, Pain, Postoperative, Anxiety Postoperative
Interventions: Meditation; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 12 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

Conditions: Pain
Interventions: Buprenorphine, Placebo; Drug
Lead sponsor: INSYS Therapeutics Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 322 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 4
States / cities: Phoenix, Arizona • Anaheim, California • Pasadena, Maryland + 1 more

Conditions: Pain, Pain Control, Postoperative Pain
Interventions: Postoperative; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 99 Years
Enrollment: 100 participants
Timeline: 2018
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Acute Pain, Postoperative Pain Control
Interventions: Experimental: LTG-001 High Dose, Experimental: LTG-001 Low Dose, Active Comparator: HB/APAP, Placebo Comparator; Drug
Lead sponsor: Latigo Biotherapeutics; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 343 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 5
States / cities: Phoenix, Arizona • Atlanta, Georgia • Houston, Texas + 2 more

Conditions: Symptomatic Apical Periodontitis, Postoperative Pain, Mechanical Allodynia
Interventions: Adjunctive Photobiomodulation, Sham Photobiomodulation; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Hysterectomy, Post Operative Analgesia
Interventions: Bupivacain, Saline (NaCl 0,9 %) (placebo); Drug · Other
Lead sponsor: MediSys Health Network; Other
Eligibility: 18 Years and older · Female only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Flushing, New York

Conditions: Pain
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 10 Years to 18 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Peripheral Arterial Disease
Interventions: Bupivacaine liposome, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Eau Claire, Wisconsin

Conditions: Post-surgical Pain
Interventions: Music Therapy; Other
Lead sponsor: Beth Israel Medical Center; Other
Eligibility: 40 Years to 55 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Pain, Postoperative, Postoperative Nausea and Vomiting, Postoperative Hemorrhage, Body Weight Changes
Interventions: Norco (Hydrocodone and Acetaminophen), Percocet (Oxycodone and Acetaminophen), Dilaudid (hydromorphone), Tylenol (Acetaminophen); Drug
Lead sponsor: University of Nebraska; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Vasectomy, Pain, Postoperative, Anxiety Postoperative
Interventions: SmileyScope Virtual Reality Headset; Device
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older · Male only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Failed Back Surgery Syndrome, Post-laminectomy Syndrome
Interventions: PrimeAdvanced® neurostimulator system; Device
Lead sponsor: MedtronicNeuro; Industry
Eligibility: 22 Years and older
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 27
States / cities: Phoenix, Arizona • Carlsbad, California • Fountain Valley, California + 22 more

Search by objective public record fields.

Interscalene Catheter vs. Interscalene Liposomal Bupivacaine for Arthroscopic Rotator Cuff Repair

The Effect of Abdominal Binder Use on Postoperative Pain and Mobility in Patients Undergoing Pelvic Surgery

Journavx to Treat Pain After Thumb Basal Joint Arthroplasty

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Articaine vs Lidocaine for Pediatric Dental Procedures

Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery

Digital Intervention Postoperative Protocol

IPACK on Early Pain Scores After ACL Reconstruction

Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks

Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

Use of Pulsed Electromagnetic Fields for Postoperative Knee Pain

Transcranial Magnetic Stimulation for the Treatment of Phantom Pain

Meditation Effects on Discomfort, Pain InTerference, and AnxieTy After urEteroscopy

Study of Buprenorphine Sublingual Spray for the Treatment of Moderate to Severe Pain

Postoperative Pain Reported to Nurses and Physicians

An Efficacy and Safety Study of LTG-001 Following Abdominoplasty

Photobiomodulation After Nonsurgical Root Canal Treatment

Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use

Pharmacogenetic Morphine Spine Study

A Study of Loco-Regional Liposomal Bupivacaine Injection

Effects of Music Therapy on the Recovery of Patients Undergoing Spine Surgery

Post-tonsillectomy Pain Control in Adults

Virtual Reality Technology for Vasectomy Pain Modulation

Subcutaneous Nerve Stimulation for Failed Back Surgery Syndrome (FBSS) Patients