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Showing 1–24 of 79 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain, Chronic Post-Surgical Clear all
Completed No phase listed Observational Results available

Pain and Function After Orthopedic Surgery

NCT01390298
View directory record Official record
Conditions
Chronic Pain
Interventions
Observational
Other
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Not applicable Interventional

iCanCope With Post-Operative Pain (iCanCope PostOp)

NCT05382962
View directory record Official record
Conditions
Pain, Chronic, Pain, Chronic Post-Surgical
Interventions
iCanCope Post Op Application
Behavioral
Lead sponsor
The Hospital for Sick Children
Other
Eligibility
12 Years to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

NCT06354699
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Telethon Kids Institute
Other
Eligibility
Up to 16 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
7
States / cities
San Francisco, California • Aurora, Colorado • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Not applicable Interventional

Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty

NCT05981105
View directory record Official record
Conditions
Chronic Pain, Opioid Use, Adductor Canal Block, Total Knee Arthroplasty
Interventions
ambIT pump with catheter, ambIT pump with sham catheter
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Terminated Phase 4 Interventional Results available

Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain

NCT01743976
View directory record Official record
Conditions
Neuropathic Pain
Interventions
Donepezil, Placebo
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Completed No phase listed Observational

TEMporal PostOperative Pain Signatures

NCT02407743
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Surgical patients' clinical progression, Genetic markers
Behavioral · Genetic
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
428 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 18, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Not applicable Interventional

Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation

NCT07199361
View directory record Official record
Conditions
Post-Surgical Pain, Chronic, Post-traumatic Pain, Chronic
Interventions
Peripheral Transcutaneous Magnetic Stimulation from MagVenture
Device
Lead sponsor
Florida International University
Other
Eligibility
19 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Completed No phase listed Observational

Persistent Post-Surgical Pain in Women With BrCA

NCT02266082
View directory record Official record
Conditions
Breast Cancer, Chronic Pain
Interventions
No intervention
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 75 Years · Female only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 27, 2018 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Not applicable Interventional

Studying Melatonin and Recovery in Teens

NCT06093477
View directory record Official record
Conditions
Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital, Kyphosis, Spondylolisthesis, Pectus Surgery, Hip Surgery
Interventions
Fast-Dissolve Melatonin Pill, Fast-Dissolve Placebo Pill
Dietary Supplement · Other
Lead sponsor
Stanford University
Other
Eligibility
12 Years to 18 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Perioperative ACT for Preventing CPSP

NCT06750874
View directory record Official record
Conditions
Back Pain, Spinal Stenosis, Spondylosis, Spondylolisthesis, Back Injury
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Samantha Meints
Other
Eligibility
22 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Lidocaine and Prevention of Chronic Pain

NCT01619852
View directory record Official record
Conditions
Surgery
Interventions
.9 normal saline placebo, Group L (lidocaine)
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Study of Opioid Use After Lumbar and Cervical Spine Surgery

NCT02674711
View directory record Official record
Conditions
Low Back Pain, Opiate Addiction, Neck Pain
Interventions
Educational Video
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Phase 2 Interventional Results available

Intravenous(IV) vs. Erector Spinae Plane Blocks in Cardiac Surgery

NCT04995497
View directory record Official record
Conditions
Erector Spinae Plane Block, Pain Control, Post-Operative Pain, Chronic
Interventions
Intravenous Administration of Lidocaine Post Cardiac Surgery, Administration of Lidocaine Post Cardiac Surgery via ESP Catheter
Drug
Lead sponsor
Archit Sharma
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Not listed Phase 4 Interventional

Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery

NCT06066879
View directory record Official record
Conditions
Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
Interventions
Ketamine Hydrochloride
Drug
Lead sponsor
AXIS Spine Center- a division of Northwest Specialty Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Coeur d'Alene, Idaho
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Jun 25, 2026, 11:08 PM EDT
Completed No phase listed Observational Results available

Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement

NCT01320150
View directory record Official record
Conditions
Persistent Postsurgical Pain
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
311 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Terminated Not applicable Interventional

Post-operative Pain Control With Acetaminophen and Ibuprofen After Functional Endoscopic Sinus Surgery

NCT05287217
View directory record Official record
Conditions
Chronic Rhinosinusitis (Diagnosis)
Interventions
Comparison of medication administration for pain control
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Surgical Outcomes Following Neurectomy Based Upon Response to Local Anesthetic Injection in Chronic Groin Pain

NCT05386693
View directory record Official record
Conditions
Hernia, Inguinal, Chronic Postoperative Pain
Interventions
Ilioinguinal nerve block
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting No phase listed Observational

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

NCT06466941
View directory record Official record
Conditions
Acute Pain, Chronic Post Operative Pain, Opioid Use
Interventions
regional anesthesia, no regional anesthesia, acute pain consultation, no acute pain consultation
Procedure · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy

NCT04019834
View directory record Official record
Conditions
Breast Cancer, Mastectomy, Anesthesia, Local, Narcotic Use
Interventions
regional nerve block with local anesthesia of bupivacaine with steroid, Placebo regional nerveblock with normal saline
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Jun 25, 2026, 11:08 PM EDT
Not listed No phase listed Observational

Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain

NCT04681183
View directory record Official record
Conditions
Chronic Post-surgical Pain
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Jun 25, 2026, 11:08 PM EDT
Terminated Not applicable Interventional

SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study

NCT01990287
View directory record Official record
Conditions
Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
Interventions
SCS and PNfS, SCS Alone
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
28
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 24 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery

NCT04637802
View directory record Official record
Conditions
Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital, Kyphosis, Spondylolisthesis
Interventions
CBT (SurgeryPal), Education
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
433 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients

NCT01053572
View directory record Official record
Conditions
Low Back Pain
Interventions
Adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Jun 25, 2026, 11:08 PM EDT
Completed No phase listed Observational

Patient Controlled Analgesia Pharmacogenetic Study

NCT01731873
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 18 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Jun 25, 2026, 11:08 PM EDT