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ClinicalTrials.gov public records Last synced Sep 30, 2026, 7:29 AM EDT

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Showing 49–72 of 1,791 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain, Musculoskeletal Clear all
Recruiting Not applicable Interventional

The PROACTIVE Study for Black Elders

NCT06512727
View directory record Official record
Conditions
Musculoskeletal Pain, Chronic Pain, Osteoarthritis, Pain, Chronic, Movement Evoked Pain
Interventions
PROACTIVE Intervention
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 92 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 30, 2026, 7:29 AM EDT
Recruiting Not applicable Interventional

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

NCT06887829
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Low dose radiotherapy, Sham comparator
Radiation · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years to 100 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Phase 2 Interventional

HKT-500-US12 In Adult Patients With OA Knee Pain

NCT00647231
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
HKT-500 Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
45 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2015 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Omega-3 Fatty Acid Supplementation to Enhance Performance

NCT05924139
View directory record Official record
Conditions
Strength, Body Composition, Muscle Soreness
Interventions
Omega-3 fatty acid, Placebo
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 25 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2023 · Synced Sep 30, 2026, 7:29 AM EDT
Terminated Phase 1 Interventional

Managing Chronic Tendon Pain by Metformin

NCT06100822
View directory record Official record
Conditions
Tendinopathy, Chronic Pain, Achilles Tendinopathy
Interventions
Metformin, Placebo
Drug
Lead sponsor
James Wang
Other
Eligibility
18 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Not applicable Interventional

A Multi-Site Evaluation of the Pain Relief, Support, Fit and Comfort From Use of a Custom Knee or Ankle Brace in Persons Suffering From Chronic Ankle or Knee Pain and Instability

NCT02682654
View directory record Official record
Conditions
Joint Instability
Interventions
Dr. Scholl's Prototype Ankle Brace, Dr. Scholl's Prototype Knee Brace
Device
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 65 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
2
States / cities
Colorado Springs, Colorado • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Phase 4 Interventional

Treatment of Plantar Fasciitis With Dorsiflexion Night Splints and Medial Arch Supports

NCT00222911
View directory record Official record
Conditions
Plantar Fasciitis
Interventions
dorsiflexion night splint, medial arch support
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2008 · Synced Sep 30, 2026, 7:29 AM EDT
Completed No phase listed Observational

How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)

NCT04020471
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
Interventions
Pain Scale/Medication Log
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Sep 30, 2026, 7:29 AM EDT
Active, not recruiting Not applicable Interventional

Microcurrent for Fibromyalgia

NCT04949100
View directory record Official record
Conditions
Fibromyalgia
Interventions
Microcurrent Transcutaneous Electrical Nerve Stimulator (TENS) for pain relief, PLACEBO Microcurrent Transcutaneous Electrical Nerve Stimulator (TENS) for pain relief
Device
Lead sponsor
Paul Crawford
Federal
Eligibility
18 Years to 74 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Nellis Air Force Base, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilizing the Trunk as a Proximal Lever to Strengthen the Hip Musculature and Alter Lower Extremity Function

NCT03285464
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Triplanar Rotary Resistance
Other
Lead sponsor
High Point University
Other
Eligibility
18 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Sep 30, 2026, 7:29 AM EDT
Not yet recruiting Not applicable Interventional

Light Bulb Stimuli to Reduce Chronic Pain

NCT07825792
View directory record Official record
Conditions
Fibromyalgia, Musculoskeletal Pain
Interventions
S-Cone Stimulating Chromatic Light, Equal-Energy White Light
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 30, 2026, 7:29 AM EDT
Terminated Not applicable Interventional Results available

Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA

NCT04712019
View directory record Official record
Conditions
Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases, Musculoskeletal Diseases, Edema Leg, Joint Pain, Arthritis Knee
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
Annapolis, Maryland • Baltimore, Maryland • Columbia, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 30, 2026, 7:29 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TaiChi-DTx for Treating Long Covid Symptoms

NCT05419219
View directory record Official record
Conditions
Fatigue, Dyspnea, Cognitive Impairment, Muscle Pain
Interventions
the multi-domain Tai Chi Digital therapy Software Application
Device
Lead sponsor
Tim Shi
Other
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ellicott City, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Sep 30, 2026, 7:29 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

SPRINT: Signature for Pain Recovery IN Teens

NCT04285112
View directory record Official record
Conditions
Pain, Chronic, Pain, Joint Pain, Musculoskeletal Pain
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
11 Years to 18 Years
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
2
States / cities
Palo Alto, California • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Not applicable Interventional

Pilot Study of the Efficacy & Safety of Natural Eggshell Membrane (NEM) for Joint & Connective Tissue Disorders

NCT00750230
View directory record Official record
Conditions
Osteoarthritis, Fibromyalgia
Interventions
NEM
Dietary Supplement
Lead sponsor
ESM Technologies, LLC
Industry
Eligibility
18 Years to 100 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Carthage, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Relationship to Dose of Triamcinolone Acetonide and Methylyprednisolone to Improvement in Subacromial Bursitis

NCT02242630
View directory record Official record
Conditions
Subacromial Bursitis, Shoulder Pain
Interventions
Methylprednisolone, 20 mg, Methylprednisolone, 40 mg, Triamcinolone, 20 mg, Triamcinolone, 40 mg
Drug
Lead sponsor
Keesler Air Force Base Medical Center
Federal
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Keesler Air Force Base, Mississippi
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Sep 30, 2026, 7:29 AM EDT
Withdrawn Phase 4 Interventional

Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

NCT04134442
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Shoulder Pain, Pain, Postoperative
Interventions
Bupivacaine Liposome Injection, Standard Therapy
Drug · Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 6, 2022 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for Hemiplegic Shoulder Pain

NCT01123382
View directory record Official record
Conditions
Stroke, Shoulder Pain
Interventions
Intramuscular Electrical Stimulator, Outpatient Therapy
Device · Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Sep 30, 2026, 7:29 AM EDT
Recruiting No phase listed Observational

The BRIDGE Pain Study

NCT07602595
View directory record Official record
Conditions
Juvenile Idiopathic Arthritis (JIA), Fibromyalgia, Lupus, Scoliosis, Pectus Excavatum, Chronic Pain, Musculoskeletal Pain
Interventions
Not applicable- observational study
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
14 Years to 26 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Phase 1 Interventional

AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain

NCT03263611
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Placebo, AMG0103
Drug
Lead sponsor
AnGes, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
6
States / cities
Los Angeles, California • San Diego, California • St. Petersburg, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Sep 30, 2026, 7:29 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)

NCT04770064
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
High-dose/short-duration Fisetin, Low-dose/sustained-duration Fisetin, Oral placebo capsule
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
35 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 29, 2022 · Synced Sep 30, 2026, 7:29 AM EDT
Terminated Phase 4 Interventional

Efficacy and Safety of Coenzyme Q10 in the Treatment of Statin-Associated Myalgia

NCT00590408
View directory record Official record
Conditions
Statin-associated Myalgia
Interventions
coenzyme Q10, matching placebo
Dietary Supplement
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 79 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 1, 2009 · Synced Sep 30, 2026, 7:29 AM EDT
Completed No phase listed Observational

Misoprostol for Spinal Stenosis

NCT04611464
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Low Back Pain
Interventions
Misoprostol
Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Sep 30, 2026, 7:29 AM EDT
Completed Phase 4 Interventional Results available

Intra-articular Morphine and Clonidine Injections for Pain Management in Hip Arthroscopy

NCT02530151
View directory record Official record
Conditions
Femoracetabular Impingement, Pain, Postoperative
Interventions
Morphine with clonidine, Normal saline
Drug · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 23, 2019 · Synced Sep 30, 2026, 7:29 AM EDT