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ClinicalTrials.gov public records Last synced Oct 29, 2026, 9:59 AM EDT

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Showing 1–24 of 1,851 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain, Post-operative Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

NCT06513208
View directory record Official record
Conditions
Lumbar Spinal Fusion
Interventions
Ketorolac Tromethamine, Placebo
Drug
Lead sponsor
University of Maryland St. Joseph Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 29, 2026, 9:59 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Mindfulness/Meditation on Post-operative Pain and Opioid Consumption

NCT04855968
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
In addition to standard post-op medication patient will have access to the head space meditation application., Patients will take standard post-op pain medication
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Continuous Femoral Nerve Block Following Total Knee Replacement

NCT00135889
View directory record Official record
Conditions
Pain
Interventions
Femoral perineural infusion
Drug
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
2
States / cities
La Jolla, California • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2009 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Local Infiltration Analgesia for Hip Arthroscopy

NCT01454518
View directory record Official record
Conditions
Pain
Interventions
Infiltration of local anesthetic, Normal Saline Injection
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 11, 2013 · Synced Oct 29, 2026, 9:59 AM EDT
Not listed Not applicable Interventional

Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients

NCT05276258
View directory record Official record
Conditions
Pain, Pain, Postoperative
Interventions
cryoSPHERE Ablation, Bupivacaine
Device · Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 90 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2023 · Synced Oct 29, 2026, 9:59 AM EDT
Withdrawn Phase 4 Interventional

Pericapsular Nerve Group Block (PENG) for Hip Surgery

NCT05118620
View directory record Official record
Conditions
Hip Arthropathy, Postoperative Pain, Acute, Pain, Postoperative
Interventions
Active bupivacaine 0.375% PENG block, Placebo normal saline PENG block
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2022 · Synced Oct 29, 2026, 9:59 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Postoperative Pain After Activation of Irrigant

NCT06528574
View directory record Official record
Conditions
Pain
Interventions
Conventional root canal treatment, Ultrasonic, Apical negative pressure, Combined Ultrasonic and negative pressure
Device
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Phase 4 Interventional Results available

Effect of Oral Choline Supplementation on Postoperative Pain

NCT00720343
View directory record Official record
Conditions
Postoperative Pain, Inflammation
Interventions
Choline, Placebo
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Oct 29, 2026, 9:59 AM EDT
Completed No phase listed Observational

Single Dose Pharmacokinetics and Pharmacodynamics of Bupivacaine Following Transversus Abdominis Plane (TAP) Block in Neonates

NCT01557985
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine
Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
Up to 28 Days
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 29, 2026, 9:59 AM EDT
Withdrawn Not applicable Interventional

Coordinated Reset Spinal Cord Stimulation

NCT04997278
View directory record Official record
Conditions
Pain, Neuropathic, Failed Back Surgery Syndrome
Interventions
Coordinated Reset spinal cord stimulation
Device
Lead sponsor
Stanford University
Other
Eligibility
22 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2023 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Patient Controlled Analgesia Pump Cues on Patient Satisfaction

NCT02456909
View directory record Official record
Conditions
Postoperative Pain
Interventions
Patient-Controlled Analgesia pump with Cues, Patient-Controlled Analgesia pump without Cues, Morphine
Device · Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
7 Years to 18 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Oct 29, 2026, 9:59 AM EDT
Withdrawn Not applicable Interventional

Pain Management in Children Undergoing Supracondylar Humerus Fracture Repair

NCT01812863
View directory record Official record
Conditions
Humeral Fractures, Fractures, Closed
Interventions
Supraclavicular nerve block
Procedure
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
2 Years to 10 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Phase 3 Interventional Results available

Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients

NCT01944098
View directory record Official record
Conditions
Bariatric Surgical Pain
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 29, 2026, 9:59 AM EDT
Not listed Not applicable Interventional

Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery

NCT04730531
View directory record Official record
Conditions
Postoperative Pain, Spinal Fusion
Interventions
Local infiltration with 0.25% bupivacaine and epinephrine, Placebo of equal volume injectable saline
Procedure
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Pain After Laparoscopic Cholecystectomy With Bilateral Tranversus Abdominis Plane (TAP) Block Versus Local Anesthetic Infiltration

NCT01204892
View directory record Official record
Conditions
Postoperative Pain
Interventions
TAP Block, Local infiltration
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 12, 2012 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Phase 4 Interventional Results available

Regional Block for Postoperative Free Flap Care

NCT04080739
View directory record Official record
Conditions
Pain Management
Interventions
ropivicaine 0.2%
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study of Acetaminophen for Post Surgical Dental Pain

NCT04018612
View directory record Official record
Conditions
Pain, Postoperative, Dental Pain
Interventions
Acetaminophen, Placebo
Drug · Other
Lead sponsor
Nevakar, Inc.
Industry
Eligibility
17 Years to 55 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 29, 2022 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Preliminary Study of CA-008 (Vocacapsaicin) in Patients Undergoing Ventral Hernia Repair

NCT04774328
View directory record Official record
Conditions
Postsurgical Pain
Interventions
CA-008 (vocacapsaicin), Placebo
Drug
Lead sponsor
Concentric Analgesics
Industry
Eligibility
18 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Oct 29, 2026, 9:59 AM EDT
Withdrawn Phase 4 Interventional

Ketolorac Versus Saline at Laparoscopic Incision Sites

NCT01374828
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Ketolorac
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Beachwood, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 10, 2013 · Synced Oct 29, 2026, 9:59 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Comparison of Anesthetic Techniques on Total Hip Arthroplasty

NCT01359865
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lumbar Plexus Block
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2015 · Synced Oct 29, 2026, 9:59 AM EDT
Not yet recruiting Not applicable Interventional

Gastrectomy at Low Pressure Trial - (GALPT)

NCT07313930
View directory record Official record
Conditions
Pain, Postoperative
Interventions
AirSeal® Insufflation System (AIS), Lexicon AP 50/30 Insufflator
Device
Lead sponsor
SurgiQuest, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 2, 2026 · Synced Oct 29, 2026, 9:59 AM EDT
Terminated Phase 2 Interventional Results available

Dose Finding Posterolateral Thoracotomy Study

NCT00807209
View directory record Official record
Conditions
Postoperative Pain
Interventions
Low Dose SKY0402, High Dose SKY0402, Placebo, Fentanyl via PCA, Bupivacaine via epidural
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
5
States / cities
Pasadena, California • Orlando, Florida • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated May 15, 2012 · Synced Oct 29, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Dose Response Study of Dexamethasone in Combination With Bupivacaine 0.25%

NCT01690663
View directory record Official record
Conditions
Post Surgical Pain
Interventions
Bupivacaine 0.25%, Dexamethasone, normal saline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2017 · Synced Oct 29, 2026, 9:59 AM EDT
Active, not recruiting Phase 1 Interventional

Psilocybin-assisted Therapy for Phantom Limb Pain

NCT05224336
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Psilocybin, Placebo Niacin
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 29, 2026, 9:59 AM EDT