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ClinicalTrials.gov public records Last synced Oct 23, 2026, 6:39 AM EDT

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Showing 1–24 of 94 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain, Procedural Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide Use in Minor Procedures

NCT01911351
View directory record Official record
Conditions
Laceration, Abscess
Interventions
Nitrous Oxide
Drug
Lead sponsor
New York City Health and Hospitals Corporation
Other
Eligibility
3 Years to 12 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 11, 2016 · Synced Oct 23, 2026, 6:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Remimazolam Sedation for Nerve Blocks

NCT05415202
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
Remimazolam 20 MG [Byfavo]
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 23, 2026, 6:39 AM EDT
Not yet recruiting Not applicable Interventional

E-MOHS Trial of TENS and Vibration During Local Anesthesia

NCT07852455
View directory record Official record
Conditions
Pain, Procedural Pain, Local Anesthesia, Mohs Surgery, Skin Cancer
Interventions
Active Vibration:TENS, Sham TENS
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
3
States / cities
Maple Grove, Minnesota • Minneapolis, Minnesota • Wyoming, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Terminated No phase listed Observational

HF10 Treatment of Chronic Knee Pain

NCT04020211
View directory record Official record
Conditions
Chronic Pain Post-Procedural
Interventions
Senza HF10 Therapy
Device
Lead sponsor
Nevro Corp
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Greenfield, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Efficacy of Lidocaine Gel Enema After Endoscopic Hemorrhoid Band Ligation for Relief of Post Procedural Pain

NCT03797703
View directory record Official record
Conditions
Hemorrhoids
Interventions
Lidocaine Hydrochloride 2% gel enema
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 4, 2024 · Synced Oct 23, 2026, 6:39 AM EDT
Recruiting Not applicable Interventional

Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

NCT05961800
View directory record Official record
Conditions
Pain, Chronic, Facet Joint Pain, Pain, Procedural, Analgesia
Interventions
Cutaneous Probe, Quantitative Sensory Testing, Computer Tasks
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain, Anxiety During Interventional Spine Procedures

NCT04257019
View directory record Official record
Conditions
Pain, Low Back Pain, Procedural Pain, Procedural Anxiety
Interventions
Lavender oil, Almond oil, Water
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 23, 2026, 6:39 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Does Preventive Analgesia Improve the Outcome of Demerol-Vistaril Procedural Sedations in Pediatric Dentistry

NCT01971853
View directory record Official record
Conditions
Pain
Interventions
oral placebo, Oral Analgesics
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
2 Years to 8 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 22, 2021 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Can Virtual Reality Reduce Pain and Anxiety During Blood Draw

NCT04449341
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
Oculus Go headset with Ocean Rift application
Device
Lead sponsor
C.R.Darnall Army Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 23, 2026, 6:39 AM EDT
Not yet recruiting Phase 2 Interventional

Investigating Pre-Procedural Anxiety and Effect of Analgesia on Intrauterine Device Placement and Endometrial Biopsy

NCT07031206
View directory record Official record
Conditions
Anxiety, Pain
Interventions
Paracervical block- Lidocaine without epinephrine, Benzocaine Gel applied to the cervix, Hydroxyzine Hydrochloride
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 23, 2026, 6:39 AM EDT
Not yet recruiting No phase listed Observational

Clinical Evidence With Biomarker Confirmation for PPMI in PCI Clinical Trials Study

NCT07848529
View directory record Official record
Conditions
Peri-procedural Myocardial Infarction, Heart Failure Hospitalization, Mortality, Stable Angina Pectoris, Non ST Elevation Myocardial Infarction (NSTEMI)
Interventions
Biomarker testing
Diagnostic Test
Lead sponsor
Baim Institute for Clinical Research
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Enrolling by invitation Not applicable Interventional

VR-PAT for Pain and Anxiety Management During Pediatric Dermatologic Laser Procedures

NCT05645224
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
VR-PAT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
5 Years to 25 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Phase 3 Interventional Results available

Pain Medicine for Wound Care Procedures

NCT00701909
View directory record Official record
Conditions
Wound Care, Pain Intensity, Hyperalgesia, Nausea, Vomiting, Hallucinations
Interventions
Morphine plus Ketamine, Morphine plus Saline (placebo)
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Not applicable Interventional

Distracting Through Procedural Pain and Distress

NCT04892160
View directory record Official record
Conditions
Chronic Illness, Hematologic Malignancy, Bone Marrow Transplant Infection, Oncology, Sickle Cell Disease
Interventions
Guided Imagery, Virtual Reality
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
8 Years to 25 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Milwaukee, Wisconsin • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 23, 2026, 6:39 AM EDT
Recruiting Phase 3 Interventional

Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen

NCT07525219
View directory record Official record
Conditions
Analgesic Efficacy
Interventions
Suzetrigine, acetaminophen
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2022 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Not applicable Interventional

Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial

NCT01269307
View directory record Official record
Conditions
Sedation
Interventions
1:1 ketamine-propofol mixture sedation, Propofol Sedation
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 12, 2014 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Not applicable Interventional

Virtual Reality in Burn Pain Management

NCT00593086
View directory record Official record
Conditions
Burns, Pain
Interventions
Pain management, Standard of care/no virtual reality game
Procedure · Other
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Oct 23, 2026, 6:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cervical Preparation for Same-Day Dilation & Evacuation

NCT06799052
View directory record Official record
Conditions
Abortion, Second Trimester, Procedural Pain, Procedural Complication
Interventions
Transcervical single-balloon catheter, Synthetic osmotic dilators
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
16 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Phase 4 Interventional

Skin Blood Flow Changes Using Laser Doppler Imager for Assessment of Pain and Analgesia in Newborn Infants

NCT00694174
View directory record Official record
Conditions
Procedural Pain
Interventions
sucrose 24% oral solution, sterile water
Drug
Lead sponsor
Children's Hospital of Michigan
Other
Eligibility
1 Day to 7 Days
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 10, 2008 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Phase 2Phase 3 Interventional

VR for Burn Dressing Changes at Home

NCT04548635
View directory record Official record
Conditions
Burns, Acute Pain, Procedural Pain
Interventions
VR-PAT
Device
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 23, 2026, 6:39 AM EDT
Enrolling by invitation Not applicable Interventional

VR for Steroid Joint Injections - Feasibility

NCT07778069
View directory record Official record
Conditions
Acute Pain, Procedural Anxiety, Juvenile Idiopahtic Arthritis
Interventions
VR-PAT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 23, 2026, 6:39 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement

NCT05875571
View directory record Official record
Conditions
IUD, Healthy Female, Contraception, IUD Insertion Complication
Interventions
Ketorolac, Placebo
Drug
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
13 Years to 21 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 23, 2026, 6:39 AM EDT
Completed Not applicable Interventional Results available

Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children

NCT01669642
View directory record Official record
Conditions
Abscess, Fracture
Interventions
Ketamine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
2 Years to 17 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Oct 23, 2026, 6:39 AM EDT