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ClinicalTrials.gov public records Last synced Oct 11, 2026, 7:53 AM EDT

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Showing 217–240 of 282 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain, Shoulder Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Mindfulness/Meditation on Post-operative Pain and Opioid Consumption

NCT04855968
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
In addition to standard post-op medication patient will have access to the head space meditation application., Patients will take standard post-op pain medication
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine After Arthroscopic Rotator Cuff Repair

NCT03149887
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Liposomal bupivacaine, Placebo
Drug
Lead sponsor
Steven Orebaugh
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2020 · Synced Oct 11, 2026, 7:53 AM EDT
Recruiting Phase 2 Interventional

Myofascial Dysfunction in Post Stroke Shoulder Pain

NCT06718413
View directory record Official record
Conditions
Stroke
Interventions
hyaluronidase plus saline, saline
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Not applicable Interventional

Prospective RCT Comparing Perioperative Pain

NCT03253198
View directory record Official record
Conditions
Arthroplasty Shoulder
Interventions
Saline, Bupivacaine liposome
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Chronic Post-Stroke Shoulder Pain Using the Smartpatch System

NCT01847885
View directory record Official record
Conditions
Post-stroke Shoulder Pain, Hemiplegic Shoulder Pain
Interventions
Smartpatch Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
5
States / cities
Chicago, Illinois • West Orange, New Jersey • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 2 Interventional Results available

Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip

NCT03382262
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Osteoarthritis of the Hip
Interventions
FX006 32 mg, TAcs 40 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
6
States / cities
El Cajon, California • La Mesa, California • San Diego, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 11, 2026, 7:53 AM EDT
Completed No phase listed Observational

Effects of Interscalene Brachial Plexus Nerve Blocks on the Hand and Forearm

NCT01229683
View directory record Official record
Conditions
Shoulder Surgery, Interscalene Nerve Block
Interventions
Interscalene Nerve Block
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Oct 11, 2026, 7:53 AM EDT
Terminated Phase 4 Interventional

Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks

NCT00875862
View directory record Official record
Conditions
Adhesive Capsulitis, Post-operative Pain
Interventions
Interscalene catheter with Ropivicaine or normal saline
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 11, 2026, 7:53 AM EDT
Completed No phase listed Observational

Single Shot vs Continuous Interscalene Block for Rotator Cuff Repair

NCT01122745
View directory record Official record
Conditions
Pain, Rotator Cuff, Surgery
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 90 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 30, 2014 · Synced Oct 11, 2026, 7:53 AM EDT
Not listed Phase 4 Interventional

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

NCT05109312
View directory record Official record
Conditions
Analgesia
Interventions
Bupivacaine Hydrochloride, HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
7
States / cities
Little Rock, Arkansas • Sarasota, Florida • Tulsa, Oklahoma + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Internet Enhanced, Patient-Centered Orthopedic Care: A Prospective, Randomized, Controlled Pilot Trial

NCT02025400
View directory record Official record
Conditions
Knee Injuries, Shoulder Injuries, Rotator Cuff Disease, Meniscus Tear, Patellofemoral Pain
Interventions
eRehab, Formal Physical Therapy
Other
Lead sponsor
Charlotte Sports Medicine Institute, PA
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
Prince Frederick, Maryland • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 1, 2014 · Synced Oct 11, 2026, 7:53 AM EDT
Terminated Not applicable Interventional

Study of the Effect of Neck Treatment on Shoulder Impingement

NCT00764764
View directory record Official record
Conditions
Shoulder Impingement, Shoulder Pain, Rotator Cuff Tendinitis, Cervical Degenerative Joint Disease
Interventions
shoulder treatment, Shoulder AND cervical treatment
Procedure
Lead sponsor
CAMC Health System
Other
Eligibility
40 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 4 Interventional Results available

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

NCT03887650
View directory record Official record
Conditions
Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
Interventions
Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 11, 2026, 7:53 AM EDT
Recruiting Phase 1Phase 2 Interventional

CBD for Pain Following Orthopedic Shoulder Surgery

NCT06381791
View directory record Official record
Conditions
Shoulder Osteoarthritis, Rotator Cuff Injuries
Interventions
Epidiolex, Placebo oral solution
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 11, 2026, 7:53 AM EDT
Terminated Phase 4 Interventional

Pain Management After Total Shoulder Arthroplasty

NCT03219983
View directory record Official record
Conditions
Glenohumeral Arthritis, Total Shoulder Arthroplasty
Interventions
Ropivacaine, liposomal bupivacaine
Drug
Lead sponsor
The Christ Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial

NCT06920264
View directory record Official record
Conditions
This Study Will Evaluate Whether TXA Reduces Pain
Interventions
Tranexamic acid, placebo
Drug · Other
Lead sponsor
St. Louis Joint Replacement Institute
Other
Eligibility
Not listed
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bridgeton, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Not applicable Interventional

Safe and Effective Shoulder Exercise Training in Manual Wheelchair Users With SCI

NCT02777281
View directory record Official record
Conditions
Shoulder Pain, Spinal Cord Injury
Interventions
Shoulder pain and SCI, Shoulder pain and able bodies
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2024 · Synced Oct 11, 2026, 7:53 AM EDT
Not yet recruiting Not applicable Interventional

Laterality Training and Pain Drawings

NCT07078084
View directory record Official record
Conditions
Chronic Musculoskeletal Pain, Chronic Shoulder Pain, Chronic Knee Pain
Interventions
Laterality Training, Sham (No Treatment)
Behavioral · Other
Lead sponsor
Hawaii Pacific University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Moline, Illinois • Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Rotator Cuff Repair Using Standard Double Row Technique With Platelet Rich Fibrin Membrane vs. Standard Double Row Technique

NCT02256891
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
PRFM, Double Row
Device · Procedure
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Not applicable Interventional Results available

Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study

NCT03578237
View directory record Official record
Conditions
Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee, Lower Limb Amputation Above Knee, Knee Arthropathy, Shoulder Arthroplasty, Rotator Cuff Repair, Video-Assisted Thoracoscopic Surgery (VATS), Skin Grafting
Interventions
Cryoneurolysis (active), Sham cryoneurolysis procedure
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2023 · Synced Oct 11, 2026, 7:53 AM EDT
Enrolling by invitation No phase listed Observational

MDR - Comprehensive Reverse/Versa Dial Ti Glenosphere

NCT04003272
View directory record Official record
Conditions
Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Arthritis, Shoulder Disease
Interventions
Comprehensive Reverse Versa-Dial Titanium Glenosphere
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
2
States / cities
Louisville, Kentucky • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of Biofreeze® on Shoulder Pain and In-office Exercise Performance

NCT01827306
View directory record Official record
Conditions
Shoulder Pain
Interventions
Biofreeze
Drug
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years to 64 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2016 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 3 Interventional

Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury

NCT00765700
View directory record Official record
Conditions
Sprain, Strain, Acute Soft Tissue Injury
Interventions
Topical Ketoprofen 10% Cream, Topical Placebo Cream
Drug
Lead sponsor
Imprimis Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 27, 2013 · Synced Oct 11, 2026, 7:53 AM EDT
Completed Phase 4 Interventional

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

NCT06109415
View directory record Official record
Conditions
Postoperative Pain, Total Shoulder Arthroplasty, Multimodal Analgesia
Interventions
HTX-011, Bupivacaine Hydrochloride, Ibuprofen, Acetaminophen, Luer lock applicator
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
5
States / cities
Little Rock, Arkansas • Jenks, Oklahoma • Bellaire, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Oct 11, 2026, 7:53 AM EDT