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Showing 1–24 of 506 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain;Back Low;Chronic Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Self-Natural Posture Exercise Programs on Chronic Low Back Pain

NCT05136729
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Self-Natural Posture Exercise training
Behavioral
Lead sponsor
Billings Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Billings, Montana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Jun 26, 2026, 3:48 AM EDT
Active, not recruiting Not applicable Interventional Results available

Development and Feasibility of Mindfulness Based Pain Reduction

NCT04980612
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Mindfulness Based Pain Reduction, Mindfulness Based Stress Reduction
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain

NCT00899600
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Ketamine, Normal saline
Drug · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Jun 26, 2026, 3:48 AM EDT
Not listed Phase 1 Interventional

New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain

NCT02008136
View directory record Official record
Conditions
Cervicalgia, Low Back Pain
Interventions
Botulinum Toxins
Drug
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 6, 2017 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Lumbar Injectrode Feasibility Evaluation

NCT06206356
View directory record Official record
Conditions
Chronic Pain, Lower Back Pain Chronic
Interventions
PNS Injectrode F1
Device
Lead sponsor
Neuronoff, Inc
Industry
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jun 26, 2026, 3:48 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Chronic Opioid Use in Low Back Pain and Lumbar Orthosis Intervention

NCT02241824
View directory record Official record
Conditions
Chronic Lower Back Pain, Chronic Opioid Use
Interventions
In-elastic lumbar brace, Elastic abdominal binder
Device
Lead sponsor
Geoffrey C. Garth
Other
Eligibility
20 Years to 72 Years · Male only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Jun 26, 2026, 3:48 AM EDT
Terminated Phase 4 Interventional Results available

Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy

NCT00619983
View directory record Official record
Conditions
Diabetic Neuropathic Pain, Chronic Low Back Pain
Interventions
donepezil, duloxetine, donepezil 2.5 mg and duloxetine 30mg, placebo, gabapentin
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Not applicable Interventional

Modifiable Work and Movement Solutions Low Back Pain in Seafood Workers

NCT03524378
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Ergonomic and movement modifications
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
Cedar Key, Florida • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Jun 26, 2026, 3:48 AM EDT
Active, not recruiting Phase 4 Interventional

Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain

NCT03888820
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Biofreeze, Placebo
Drug
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2019 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Music-based Treatments and Pain: Underlying Mechanisms and the Beneficial Effects of Music-Based Treatments

NCT05578781
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Music Therapy, Music Medicine, Control group
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Not applicable Interventional

Cooperative Pain Education and Self-management

NCT02724930
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Enhanced facilitation of COPES
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Menlo Park, California • Indianapolis, Indiana • Brockton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Jun 26, 2026, 3:48 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

NCT05419297
View directory record Official record
Conditions
Back Pain Lower Back Chronic, Chronic Pain
Interventions
Buprenorphine Buccal Film [Belbuca], Urine Drug Screening, actigraph, PROMIS 29, sit to stand test, numerical rating scale pain score, patient global impression of function, PROMIS - sleep
Drug · Other · Device + 1 more
Lead sponsor
Carolinas Pain Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Jun 26, 2026, 3:48 AM EDT
Recruiting Not applicable Interventional

A Superiority Trial of Radiofrequency Ablation for Low Back Pain

NCT07222462
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
Lumbar radiofrequency ablation with conventional electrodes (LRFA-C), Lumbar radiofrequency ablation with multi-tined electrodes (LRFA-M), Simulated lumbar radiofrequency ablation
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Atlanta, Georgia • Cleveland, Ohio • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jun 26, 2026, 3:48 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Hormones, Outcomes, and Pain Pathways in Exercise Study

NCT07579182
View directory record Official record
Conditions
Breast Pain, Mastalgia, Back Pain, Back Pain, Low, Neck Pain, Chest Pain, Activity, Motor, Healthy Aging, Weight, Body, Inflammation, Gonadal Steroid Hormones, Neuronal Plasticity, Neuromuscular Manifestations
Interventions
Interventional Sports bra
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Not applicable Interventional Results available

Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)

NCT02697435
View directory record Official record
Conditions
Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia, Depression, Maladaptive Coping, Lumbar Spinal Stenosis, Insomnia, Sacroiliac Joint Pain, Lateral Hip and Thigh Pain, Anxiety, Dementia, Recent Leg Length Discrepancy
Interventions
Patient-Centered Care, Imaging-Directed Care
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 89 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2019 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Phase 2 Interventional

Effect of Yoga Vs. Stretching on Chronic Back Pain

NCT00447668
View directory record Official record
Conditions
Chronic Non-specific Low Back Pain
Interventions
Yoga, Exercise, Self-care book recommendations
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
20 Years to 64 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Phase 4 Interventional

Pilot Study of the Efficacy and Safety of Lidoderm Patch in the Treatment of Low Back Pain

NCT00904475
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
6
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2010 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Meditation-CBT for Opioid-treated Chronic Low Back Pain

NCT01775995
View directory record Official record
Conditions
Chronic Pain, Low Back Pain
Interventions
Meditation-CBT Intervention + Usual Care, Usual Care Alone
Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 15, 2016 · Synced Jun 26, 2026, 3:48 AM EDT
Terminated Phase 3 Interventional Results available

Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Low Back Pain

NCT00313014
View directory record Official record
Conditions
Back Pain Lower Back Chronic
Interventions
Buprenorphine, Oxycodone Immediate-Release
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
660 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
85
States / cities
Birmingham, Alabama • Haleyville, Alabama • Phoenix, Arizona + 72 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2012 · Synced Jun 26, 2026, 3:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Engagement Via Crowdsourcing

NCT03264521
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Surveys
Other
Lead sponsor
RAND
Other
Eligibility
21 Years and older
Enrollment
8,193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 25, 2021 · Synced Jun 26, 2026, 3:48 AM EDT
Completed Not applicable Interventional Results available

ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation

NCT04803214
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
ReActiv8
Device
Lead sponsor
Mainstay Medical
Industry
Eligibility
21 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
28
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Newport Beach, California + 24 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jun 26, 2026, 3:48 AM EDT
Recruiting Phase 2 Interventional

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

NCT05986292
View directory record Official record
Conditions
Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
Interventions
LY3016859 ISA, LY3556050 ISA, LY3526318 ISA, LY3857210 ISA, Placebo Oral, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
62
States / cities
Birmingham, Alabama • Glendale, Arizona • Phoenix, Arizona + 52 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jun 26, 2026, 3:48 AM EDT
Active, not recruiting Phase 3 Interventional

Nonpharmacologic Pain Management in FQHC Primary Care Clinics

NCT04923334
View directory record Official record
Conditions
Low Back Pain, Chronic Pain
Interventions
Brief Pain Teleconsult, Telehealth Physical Therapy
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jun 26, 2026, 3:48 AM EDT
Not listed Not applicable Interventional

E-STIM Trial: Comparing the Efficacy of the Empi Select TENS to a Control for the Treatment of Chronic Lower Back Pain

NCT00709748
View directory record Official record
Conditions
Lower Back Pain
Interventions
Empi Select TENS Device, Placebo
Device
Lead sponsor
Empi, A DJO Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
8
States / cities
Fair Oaks, California • Pensacola, Florida • St. Petersburg, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2008 · Synced Jun 26, 2026, 3:48 AM EDT