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ClinicalTrials.gov public records Last synced Oct 27, 2026, 5:08 PM EDT

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Showing 985–1008 of 10,287 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of GentleWave System in Endodontic Treatment

NCT06518304
View directory record Official record
Conditions
Pain, Postoperative, Root Canal Infection, Endodontically Treated Teeth
Interventions
GentleWave, Conventional Protocol
Other
Lead sponsor
University of Salamanca
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional

Evolution of Analgesic Tolerance With Opioids

NCT00275249
View directory record Official record
Conditions
Chronic Pain
Interventions
levorphanol
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2011 · Synced Oct 27, 2026, 5:08 PM EDT
Not listed Not applicable Interventional

E-STIM Trial: Comparing the Efficacy of the Empi Select TENS to a Control for the Treatment of Chronic Lower Back Pain

NCT00709748
View directory record Official record
Conditions
Lower Back Pain
Interventions
Empi Select TENS Device, Placebo
Device
Lead sponsor
Empi, A DJO Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
8
States / cities
Fair Oaks, California • Pensacola, Florida • St. Petersburg, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2008 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Satisfaction Following Cesarean Section

NCT03355248
View directory record Official record
Conditions
Pain, Postoperative, Cesarean Section Complications, Postpartum Disorder, Opioid Use
Interventions
Oxycodone Acetaminophen
Other
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 18, 2020 · Synced Oct 27, 2026, 5:08 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis

NCT05551858
View directory record Official record
Conditions
Safety Issues, Pain, Pancreas Fibrosis
Interventions
Proglumide, Placebo
Drug
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 27, 2026, 5:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

NCT07464860
View directory record Official record
Conditions
Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological, Breathing Techniques, Breathing Exercises, Hypothalamic Pituitary Adrenal, Relaxation, Relaxation Therapy, Cortisol, Postoperative Pain, Postoperative Anxiety, Postoperative Depression, Quality of Recovery (QoR-15)
Interventions
A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
65 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 3 Interventional

Liposomal Bupivacaine To Control Post-Operative Pain Following BMG

NCT03720223
View directory record Official record
Conditions
Urethral Stricture
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Urology of Virginia
Other
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Virginia Beach, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 1, 2021 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of the Nottingham Augmented Reality (AR) App for Arthritis Hand Joint Pain

NCT05634291
View directory record Official record
Conditions
Chronic Pain, Arthritis Hand, Opioid Use
Interventions
Standard of care, Nottingham AR smartphone app with active intervention
Other · Device
Lead sponsor
VRx Medical Inc
Industry
Eligibility
21 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2023 · Synced Oct 27, 2026, 5:08 PM EDT
Recruiting Not applicable Interventional

Tailored Pain Guide (TPG) Study

NCT05843890
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Structured and tailored PainGuide, Standard PainGuide
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 27, 2026, 5:08 PM EDT
Recruiting Not applicable Interventional

Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery

NCT07715591
View directory record Official record
Conditions
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Interventions
Music and Guided Imagery, Control, Music Only
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 4 Interventional Results available

A Randomized Study of Three Medication Regimens for Acute Low Back Pain

NCT01587274
View directory record Official record
Conditions
Acute Low Back Pain
Interventions
Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
21 Years to 64 Years
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional Results available

Psychological Intervention Using Smartphone Technology to Alleviate Malignant Pain

NCT05774197
View directory record Official record
Conditions
Cancer Pain, Opioid Use, Cognitive Behavior Therapy
Interventions
Cognitive Behavioral Therapy for pain
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of Popular Recovery Techniques for Ultramarathon Recovery

NCT02530190
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
intermittent pneumatic compression, massage
Device · Procedure
Lead sponsor
Western States Endurance Run Research Foundation
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Oct 27, 2026, 5:08 PM EDT
Withdrawn Phase 4 Interventional

The Effect of Theraworx Foam in Carpal Tunnel Syndrome

NCT04017390
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Theraworx Foam, Placebo Foam, Theraworx Foam and night splint, Placebo Foam and night time splint
Drug · Other
Lead sponsor
John Fowler
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2022 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy Study of Hydromorphone and Morphine

NCT00195910
View directory record Official record
Conditions
Pain
Interventions
Morphine, Hydromorphone
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
198 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 3 Interventional Results available

Loteprednol Etabonate Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

NCT02208297
View directory record Official record
Conditions
Inflammation, Pain, Cataract
Interventions
Loteprednol Etabonate Gel (BID), Vehicle Gel (BID)
Drug
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional

Predictive Validity of Lumbopelvic Stress Tests to Determine Those Who Will Benefit From Lumbar Traction: A Pilot Study

NCT03127410
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar traction
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 2Phase 3 Interventional

Double-Blind, Multicenter, Study Comparing the Efficacy and Safety of OMS103HP With Vehicle Irrigation Solution in Subjects Undergoing Meniscectomy

NCT00624845
View directory record Official record
Conditions
Postoperative Pain
Interventions
OMS103HP, Vehicle
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
8
States / cities
Tucson, Arizona • Los Angeles, California • Aurora, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2011 · Synced Oct 27, 2026, 5:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

NCT00672737
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Remifentanil, Cold pain threshold and tolerance, Heat pain threshold and tolerance, Polysomnography
Drug · Procedure · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Oct 27, 2026, 5:08 PM EDT
Completed No phase listed Observational

Ethnopharmacological Studies in Oral Medicine

NCT00200837
View directory record Official record
Conditions
Oral Pain, Oral Ulcers, Oral Tumors
Interventions
Not listed
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 28, 2007 · Synced Oct 27, 2026, 5:08 PM EDT
Terminated Phase 4 Interventional Results available

Safety and Pharmacokinetic Study of EMBEDA in Children Ages 7-17 With Pain

NCT02101554
View directory record Official record
Conditions
Moderate-severe Pain
Interventions
Ages 7-11, ages 12-17
Drug
Lead sponsor
Pfizer
Industry
Eligibility
7 Years to 17 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
19
States / cities
Irvine, California • Los Angeles, California • Orange, California + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Not applicable Interventional Results available

Subcutaneous Botulinum Toxin for Cutaneous Allodynia

NCT00725322
View directory record Official record
Conditions
Pain
Interventions
Botulinum Toxin A, Placebo - Saline
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 2 Interventional Results available

Comparison of Psychological and Pharmacological Treatments for Pain Due to Temporomandibular Joint Disorder (TMD)

NCT00066937
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
Nortriptyline Oral Capsule, Benztropine Oral Product, CBT, Disease MGT
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 27, 2026, 5:08 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department

NCT03571737
View directory record Official record
Conditions
Acute Musculoskeletal Disease, Sprains, Sprains and Strains, Injuries, Emergencies, Trauma, Acute Pain
Interventions
Ibuprofen, Lidocaine Patch 4%
Drug
Lead sponsor
East Carolina University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 25, 2024 · Synced Oct 27, 2026, 5:08 PM EDT