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ClinicalTrials.gov public records Last synced Oct 19, 2026, 12:09 PM EDT

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Showing 1–24 of 897 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain Acute Clear all
Completed Phase 2 Interventional Results available

Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica

NCT00668434
View directory record Official record
Conditions
Sciatica
Interventions
Prednisone, Placebo
Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 70 Years
Enrollment
269 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
3
States / cities
Redwood City, California • Roseville, California • San Jose, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional

Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries

NCT00474721
View directory record Official record
Conditions
Pain
Interventions
ibuprofen, acetaminophen with codeine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
5 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 17, 2007 · Synced Oct 19, 2026, 12:09 PM EDT
Terminated Phase 3 Interventional

Neocartilage Implant to Treat Cartilage Lesions of the Knee

NCT01400607
View directory record Official record
Conditions
Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions
Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
Biological · Other
Lead sponsor
ISTO Technologies, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
9
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional

Internet-based Pain Self-management for Persons With Acute Recurrent and Chronic Pancreatitis Pain

NCT03322644
View directory record Official record
Conditions
Pancreatitis, Chronic, Pancreatitis, Acute Recurrent
Interventions
Internet-based CBT intervention
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 3 Interventional

A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV)

NCT02462811
View directory record Official record
Conditions
Pain, Nausea, Vomiting
Interventions
CL-108 (hydrocodone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg), Placebo, Norco (hyrdocodone 7,5 mg, acetaminophen 325 mg)
Drug
Lead sponsor
Joseph Hazelton
Industry
Eligibility
18 Years and older
Enrollment
552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 3 Interventional

Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS)

NCT00093158
View directory record Official record
Conditions
Unstable Angina, Myocardial Infarction, Acute Disease
Interventions
Angiomax (bivalirudin) anticoagulant
Drug
Lead sponsor
The Medicines Company
Industry
Eligibility
18 Years and older
Enrollment
13,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 21, 2007 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional

A Brief Intervention for Patients on Opioids for Acute Pain

NCT05658926
View directory record Official record
Conditions
Acute Pain
Interventions
Mindfulness, Education
Behavioral · Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 4 Interventional Results available

Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy

NCT05121168
View directory record Official record
Conditions
Pain, Acute Postoperative, Renal Stone
Interventions
Active bupivacaine 0.25% via an erector spinae plane perineural catheter, Placebo normal saline via an erector spinae plane perineural catheter
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

EHR-based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care

NCT02633735
View directory record Official record
Conditions
Appendicitis
Interventions
Appy CDS
Other
Lead sponsor
HealthPartners Institute
Other
Eligibility
5 Years to 20 Years
Enrollment
5,940 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Oakland, California • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 9, 2020 · Synced Oct 19, 2026, 12:09 PM EDT
Enrolling by invitation Not applicable Interventional

Alternatives to Dental Opioid Prescribing After Tooth Extraction

NCT06275191
View directory record Official record
Conditions
Analgesics, Opioid, Acute Pain, Tooth Extraction, Adolescent, Acetaminophen, Ibuprofen
Interventions
Multicomponent intervention, Usual care
Behavioral · Other
Lead sponsor
Douglas Oyler
Other
Eligibility
12 Years to 25 Years
Enrollment
38,159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00008476
View directory record Official record
Conditions
Facial Pain
Interventions
Capsaicin
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 1 Interventional

A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD).

NCT04912869
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
Crovalimab, Placebo
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
12 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Oct 19, 2026, 12:09 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Medrol Dosepak for Outpatient Total Knee Arthroplasty

NCT05097976
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methylprednisolone, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Oak Brook, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Not listed No phase listed Observational

Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease

NCT04732091
View directory record Official record
Conditions
Acute Myocardial Infarction, Unstable Angina
Interventions
Therapeutic ultrasound with 20 usec
Procedure
Lead sponsor
University of Sao Paulo General Hospital
Other
Eligibility
30 Years and older
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Oct 19, 2026, 12:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Acute Coronary Syndrome and Care-Seeking Delay: A Web Based Behavioral Study

NCT01407146
View directory record Official record
Conditions
Acute Myocardial Infarction, Heart Attack, Acute Coronary Syndrome, Unstable Angina
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
2,381 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 19, 2026, 12:09 PM EDT
Recruiting Not applicable Interventional

Imagined Acupuncture for Postoperative Pain After Spinal Surgery

NCT07197710
View directory record Official record
Conditions
Pain Management
Interventions
video-guided acupuncture imagery treatment (VGAIT), Education video
Other
Lead sponsor
Jingping Wang, MD, Ph.D.
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Promoting Self-Management of Breast and Nipple Pain With Technology (PROMPT) for Breastfeeding Women Study

NCT05262920
View directory record Official record
Conditions
Breastfeeding, Exclusive, Pain, Acute, Maternal Distress, Parent-Child Relations, Self Efficacy
Interventions
The BSM Intervention, Attention Control
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Farmington, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional

A Pilot MRI Study of Osteopathic Manipulative Treatment of Acute Low Back Pain

NCT00562562
View directory record Official record
Conditions
Low Back Pain
Interventions
osteopathic manipulative treatment
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aromatherapy for Management of Pain, Anxiety, and Nausea in the Acute Care Setting

NCT06400979
View directory record Official record
Conditions
Effectiveness of Aromatherapy
Interventions
Elequil aromatab
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 2 Interventional Results available

Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients

NCT01906008
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Minocycline, Placebo, Questionnaires, Sensory Test
Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Oct 19, 2026, 12:09 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Human Experimental Models of Pain (HEMP)

NCT07549490
View directory record Official record
Conditions
Acute Pain
Interventions
Placebo, Naproxen, Pregabalin
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 100 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 4 Interventional Results available

Sub-dissociative Ketamine for the Management of Acute Pediatric Pain

NCT01951963
View directory record Official record
Conditions
Pain
Interventions
Ketamine, Morphine
Drug
Lead sponsor
HealthPartners Institute
Other
Eligibility
3 Years to 17 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 3, 2018 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing

NCT03825549
View directory record Official record
Conditions
Acute Pain
Interventions
Individual audit feedback, Peer comparison feedback
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
452 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 19, 2026, 12:09 PM EDT
Completed Phase 3 Interventional Results available

Maxigesic® IV Phase 3 Exposure Study

NCT04005755
View directory record Official record
Conditions
Postoperative Pain
Interventions
Maxigesic® IV
Drug
Lead sponsor
AFT Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Pasadena, Maryland • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Oct 19, 2026, 12:09 PM EDT