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Showing 1–24 of 10,089 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional

Lidocaine and Tetracaine Cream to Treat Postherpetic Neuralgia (PHN)

NCT00609323
View directory record Official record
Conditions
Postherpetic Neuralgia
Interventions
lidocaine and tetracaine cream 7%/7%, Placebo
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
6
States / cities
Lexington, Kentucky • High Point, North Carolina • Winston-Salem, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2012 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Phase 1 Interventional

Methadone Pharmacokinetics and Cardiac Effects in Newborns

NCT00715988
View directory record Official record
Conditions
Pain
Interventions
Methadone HCl Inject 10 mg/ml (will require dilution), Methadone
Drug
Lead sponsor
University of Utah
Other
Eligibility
29 Weeks to 48 Weeks
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2017
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 10, 2026, 1:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Dissecting the Heterogeneity of Oral Cancer Pain

NCT05024383
View directory record Official record
Conditions
Oral Squamous Cell Carcinoma
Interventions
Chemical sensitivity, Mechanical sensitivity
Other
Lead sponsor
NYU College of Dentistry
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Omnitram Pharmacokinetic Study In Healthy Volunteers

NCT02205554
View directory record Official record
Conditions
Pain
Interventions
Omnitram, Tramadol, Placebo
Drug
Lead sponsor
Syntrix Biosystems, Inc.
Industry
Eligibility
21 Years to 55 Years · Male only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 14, 2014 · Synced Sep 10, 2026, 1:22 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Combination of Preoperative Gabapentin and TAP Blocks in Decreasing Postoperative Pain

NCT02927405
View directory record Official record
Conditions
Postoperative Pain
Interventions
Gabapentin, TAP Block
Drug · Procedure
Lead sponsor
State University of New York - Downstate Medical Center
Other
Eligibility
18 Years to 60 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Phase 4 Interventional Results available

Effect of L-dopa In Subacute Back Pain Population

NCT01951105
View directory record Official record
Conditions
Sub-acute Back Pain
Interventions
Naproxen, Carbidopa/Levodopa, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 10, 2026, 1:22 AM EDT
Recruiting Phase 2Phase 3 Interventional

Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache

NCT06621329
View directory record Official record
Conditions
SAH (Subarachnoid Hemorrhage), Headache
Interventions
Transnasal sphenopalatine ganglion block
Combination Product
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

NCT05919745
View directory record Official record
Conditions
Pain, Post Operative, Quality of Life
Interventions
Ibuprofen 600 mg, Placebo, Acetaminophen
Drug
Lead sponsor
Marquette University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Sep 10, 2026, 1:22 AM EDT
Not yet recruiting Phase 3 Interventional

Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT

NCT07158567
View directory record Official record
Conditions
Chronic Low Back Pain, Musculoskeletal Pain
Interventions
intermittent theta burst stimulation, LoveYourBrain Yoga Program
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years and older
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Active, not recruiting Not applicable Interventional

Chronic Pain Management In Primary Care Using Behavioral Health Consultants

NCT04680000
View directory record Official record
Conditions
Chronic Pain
Interventions
Brief Cognitive Behavioral Therapy for Chronic Pain (BCBT-CP), BCBT-CP Booster
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
716 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
5
States / cities
Bethesda, Maryland • Fort Hood, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Phase 2 Interventional Results available

Trial of Dronabinol and Vaporized Cannabis in Chronic Low Back Pain

NCT02460692
View directory record Official record
Conditions
Cannabis, Low Back Pain, Neuropathic Pain
Interventions
Placebos, dronabinol, Vaporized Cannabis 3.7% THC/5.6% CBD
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
19 Years to 70 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Directional Specific Thoracic Spine Mobilization on Cervical Spine Pain

NCT01917071
View directory record Official record
Conditions
Neck Pain
Interventions
thoracic spine manipulation
Other
Lead sponsor
Chatham University
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2015 · Synced Sep 10, 2026, 1:22 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Intraperitoneal Infusion of Analgesic for Postoperative Pain Management

NCT04130464
View directory record Official record
Conditions
Hysterectomy, Gynecologic Surgical Procedures, Narcotic Use, Pain, Postoperative
Interventions
Ropivacaine Infusion from ON-Q Pump, Ropivacaine + Ketorolac Infusion from ON-Q Pump, Normal Saline Infusion from ON-Q Pump
Drug
Lead sponsor
Ying Liu
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain

NCT05575999
View directory record Official record
Conditions
Pain Management
Interventions
Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination
Drug
Lead sponsor
Kansas City Heart Rhythm Research Foundation
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
3
States / cities
Loma Linda, California • Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Thermal Analgesia in Newborns

NCT00740298
View directory record Official record
Conditions
Pain
Interventions
sucrose, warmth
Other
Lead sponsor
University of Chicago
Other
Eligibility
Up to 2 Days
Enrollment
178 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Spencer's Technique on Shoulder Function

NCT06447493
View directory record Official record
Conditions
Shoulder
Interventions
Osteopathic Manipulative Treatment-Spencer's Technique (Modified), Rest
Other
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Terminated Phase 3 Interventional Results available

rTMS for the Treatment of Chronic Pain in GW1 Veterans

NCT01608321
View directory record Official record
Conditions
Chronic Pain
Interventions
rTMS, Sham device
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Sep 10, 2026, 1:22 AM EDT
Terminated Phase 3 Interventional Results available

A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety

NCT00364533
View directory record Official record
Conditions
Arthroplasty
Interventions
Tapentadol IR (CG5503), Placebo, Oxycodone HCL IR
Drug
Lead sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Industry
Eligibility
18 Years to 80 Years
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
45
States / cities
Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 42 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2014 · Synced Sep 10, 2026, 1:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Paracervical Block for Pain Control With Osmotic Dilator Placement

NCT02354092
View directory record Official record
Conditions
Abortion Late, Pain
Interventions
Local anesthetic for tenaculum placement, Sham, Paracervical Block, Dilator Placement, Post-procedural assessment, Preprocedural pain control
Procedure · Behavioral · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 10, 2026, 1:22 AM EDT
Terminated Phase 3 Interventional

Modafinil in Opioid Induced Sedation

NCT00267332
View directory record Official record
Conditions
Cancer, Pain
Interventions
Modafinil
Drug
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Sep 10, 2026, 1:22 AM EDT
Recruiting No phase listed Observational

Pain and Disability Outcomes in Post Amputation Patients

NCT05716321
View directory record Official record
Conditions
Limb Pain, Phantom, Residual Limbs Pain, Disability Physical
Interventions
Not listed
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Not yet recruiting Phase 3 Interventional

Morphine or Ketamine for Analgesia

NCT06835504
View directory record Official record
Conditions
Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
Interventions
Ketamine hydrochloride, Morphine sulphate
Drug
Lead sponsor
Columbia University
Other
Eligibility
6 Years to 17 Years
Enrollment
1,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Los Angeles, California • Sacramento, California • Wilmington, Delaware + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 10, 2026, 1:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica

NCT00847236
View directory record Official record
Conditions
Polymyalgia Rheumatica, Rheumatoid Arthritis, Rheumatic Disease
Interventions
Not listed
Lead sponsor
Lahey Clinic
Other
Eligibility
50 Years and older
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Arlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 22, 2017 · Synced Sep 10, 2026, 1:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Functional Brain Imaging of Pain Phenotype and Genotype

NCT01777087
View directory record Official record
Conditions
Pain
Interventions
gauze soaked with capsaicin
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Sep 10, 2026, 1:22 AM EDT