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ClinicalTrials.gov public records Last synced Jun 26, 2026, 4:48 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain Relief Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Efficacy of a Controlled Short-term Trial of Cannabidiol (CBD) Ingestion on Reducing Symptomatic Response and Facilitating Recovery After Induced Muscle Injury

NCT04586712
View directory record Official record
Conditions
Muscle Injury, Recovery, Pain Relief
Interventions
Active CBD, Vehicle Control (Placebo)
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 35 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 2 Interventional

Celebrex for Pain Relief After Oral Surgery

NCT00006299
View directory record Official record
Conditions
Facial Pain
Interventions
Celebrex
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Not applicable Interventional Results available

Buzzy Versus Vapocoolant Spray: Pediatric Needle Pain Relief

NCT00919100
View directory record Official record
Conditions
Pain
Interventions
Buzzy, vapocoolant
Device · Other
Lead sponsor
Georgia State University
Other
Eligibility
4 Years to 18 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Gabapentin for Perioperative Pain Relief in Surgical Abortion

NCT04292171
View directory record Official record
Conditions
Pain Control
Interventions
Gabapentin, Placebos
Drug
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older · Female only
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 1, 2020 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

An Investigation Into the Efficacy of a Botanical Supplement to Provide Period Relief

NCT05845970
View directory record Official record
Conditions
Menstrual Pain, Premenstrual Syndrome
Interventions
Pamprin Botanicals, Pamprin Botanicals + Pamprin Menstrual Pain Relief
Other · Combination Product
Lead sponsor
Focus Consumer Healthcare
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Jun 26, 2026, 4:48 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Opioid-Free Anesthetic for Tonsillectomy

NCT04528173
View directory record Official record
Conditions
Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder, Surgery
Interventions
Ketorolac, Dexmedetomidine, Morphine, Fentanyl
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Years to 18 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 1 Interventional

Study of a Steroid Delivery System for Pain Relief Treatment in Patients With Knee Osteoarthritis

NCT02873273
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Dexamethasone
Drug
Lead sponsor
Mark Figgie
Other
Eligibility
40 Years to 99 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2018 · Synced Jun 26, 2026, 4:48 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Study of Use of Synera for Pain During Local Skin Infiltration With Lidocaine Before Epidural Placement

NCT01775605
View directory record Official record
Conditions
Pain, Anxiety
Interventions
Synera
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 2 Interventional Results available

A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy.

NCT00530764
View directory record Official record
Conditions
Palliative Care, Pain, Cancer
Interventions
Sativex Low Dose, Sativex Medium Dose, Sativex High Dose
Drug
Lead sponsor
GW Pharmaceuticals Ltd
Industry
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
23
States / cities
Tuscaloosa, Alabama • Casa Grande, Arizona • Fountain Valley, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2013 · Synced Jun 26, 2026, 4:48 PM EDT
Recruiting Not applicable Interventional

This Project is a Three-arm RCT Evaluating Two, Single-session Behavioral Interventions for Adults With Chronic Musculoskeletal Pain (CMP) -- 1) Brief Mindfulness-Oriented Recovery Enhancement (B-MORE) vs. Empowered Relief (ER) -- Relative to the Traditional 8-week Version of MORE.

NCT07193095
View directory record Official record
Conditions
Chronic Musculoskeletal Pain
Interventions
Brief Mindfulness Oriented Recovery Enhancement, Empowered Relief, Mindfulness Oriented Recovery Enhancement
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Jun 26, 2026, 4:48 PM EDT
Recruiting No phase listed Observational

RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

NCT01719055
View directory record Official record
Conditions
Pain
Interventions
neurostimulation system
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
4,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2035
U.S. locations
67
States / cities
Phoenix, Arizona • Tucson, Arizona • Campbell, California + 60 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Electrical Nerve Stimulation (TENS) Therapy for Pain Relief Following Total Knee Arthroplasty (TKA)

NCT01641471
View directory record Official record
Conditions
Osteoarthritis, Knee, Arthritis, Pain
Interventions
EMPI Select TENS, Placebo EMPI Select TENS
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2018 · Synced Jun 26, 2026, 4:48 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Pain Relief After PrimaryTKA

NCT05751421
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Zynrelef (Bupivacaine 60 MG / Meloxicam 1.8 MG) Per 2.3 ML Extended Release Solution, Bupivacaine HCl 0.5% Injectable Solution, primary total knee replacement
Drug · Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Jun 26, 2026, 4:48 PM EDT
Terminated Phase 3 Interventional

Comparison of Low-dose Epidural With Intravenous Narcotic Versus Intravenous Narcotic Alone

NCT00287326
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine, Clonidine, Morphine
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
4 Years to 16 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Jun 26, 2026, 4:48 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

nCap Pain Relief Patch vs. Placebo

NCT04753567
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
nCap pain relief patch, Sham Patch
Device
Lead sponsor
nCap Medical
Industry
Eligibility
40 Years to 79 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Not applicable Interventional Results available

Feasibility Study of FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases

NCT04592887
View directory record Official record
Conditions
Bone Metastasis
Interventions
FLASH Radiotherapy
Radiation
Lead sponsor
Varian, a Siemens Healthineers Company
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Not applicable Interventional

An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks

NCT03556787
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
BPI 1000013 (Dr Scholls Insole)
Device
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 70 Years · Male only
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
2
States / cities
Calabasas, California • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 22, 2018 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Not applicable Interventional

The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function

NCT01854892
View directory record Official record
Conditions
Low Back Pain
Interventions
Manipulation, Mobilization, Laser Therapy
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 45 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 4 Interventional

Narcotic vs. Non-narcotic Pain Study Protocol

NCT01974609
View directory record Official record
Conditions
Carpal Tunnel
Interventions
Narcotic, non-narcotic
Drug
Lead sponsor
Horizon Health Network
Other
Eligibility
18 Years to 90 Years
Enrollment
347 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • Sioux Falls, South Dakota • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Jun 26, 2026, 4:48 PM EDT
Terminated Phase 4 Interventional Results available

Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery

NCT01588158
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Acetaminophen, Vicodin
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 3 Interventional Results available

Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy

NCT00468052
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
dexmedetomidine, fentanyl
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
2 Years to 10 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Jun 26, 2026, 4:48 PM EDT
Withdrawn Phase 4 Interventional

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

NCT03547778
View directory record Official record
Conditions
Office Hysteroscopy and Endometrial Biopsy
Interventions
Misoprostol 50 mcg pesssary, Placebos
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 17, 2021 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Phase 2 Interventional Results available

Comparison of Loss of Resistance Techniques

NCT00638274
View directory record Official record
Conditions
Pain Relief
Interventions
Air, Saline
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Female only
Enrollment
356 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 8, 2018 · Synced Jun 26, 2026, 4:48 PM EDT
Completed Not applicable Interventional

Nerve Stimulation Using a TENS to Provide Pain Relief During Surgery for Overactive Bladder

NCT05330117
View directory record Official record
Conditions
Urinary Incontinence, Overactive Bladder, Pain, Acute
Interventions
TENS, Control TENS
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Jun 26, 2026, 4:48 PM EDT