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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Pain Threshold Clear all
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds

NCT06792474
View directory record Official record
Conditions
Spinal Disease, Anesthesia, Post Operative Pain
Interventions
Lidocaine in Saline, Normal saline
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 2, 2026, 1:28 AM EDT
Completed No phase listed Observational

Development of a Questionnaire to Measure Hypervigilance for Visceral Pain

NCT01166802
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2010 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Duration of Effects of Massage in Healthy Participants

NCT05317702
View directory record Official record
Conditions
Healthy, Pressure Pain Threshold, Massage
Interventions
Moderately Painful Massage
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Local and Widespread Hypoalgesic Effects of Neurodynamic Mobilization in Healthy Controls

NCT03674489
View directory record Official record
Conditions
Pain, Pain, Neuropathic
Interventions
Neurodynamic Slider Mobilization, Neurodynamic Tensioner Mobilization, Sham Neurodynamic Mobilization
Other
Lead sponsor
Brenau University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2019 · Synced Sep 2, 2026, 1:28 AM EDT
Not yet recruiting Not applicable Interventional

Marine Lipids Ease Painful TMD

NCT07437313
View directory record Official record
Conditions
Temporomandibular Disorder (TMD)
Interventions
SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Influence of Genetics in Pain Sensitivity

NCT00001956
View directory record Official record
Conditions
Healthy, Hyperalgesia, Pain
Interventions
Blood draw, Oral surgery, Tissue biopsy
Procedure
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2006 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers

NCT03233737
View directory record Official record
Conditions
No Disease State or Condition
Interventions
One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
Combination Product · Device
Lead sponsor
Cetylite Industries
Industry
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity

NCT05985382
View directory record Official record
Conditions
Healthy
Interventions
Lower Body Resistance Exercise, Upper Body Resistance Exercise
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Sep 2, 2026, 1:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pain Inhibition With Neuromuscular Electrical Stimulation

NCT05280522
View directory record Official record
Conditions
Healthy Participants
Interventions
Volitional Contractions (VOL), Neuromuscular Electrical Stimulation (NMES), Noxious Electrical Stimulation (NXES)
Other · Device
Lead sponsor
University of New England
Other
Eligibility
18 Years to 30 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management

NCT07160049
View directory record Official record
Conditions
Pain Management, Peripheral Neuropathic Pain
Interventions
Cold Pressor Task - Upper Limb, Algometry Pain Tests in the Upper Limb, Algometry Pain Tests in the Lower Limb
Device
Lead sponsor
Evan (Huiliang) Wang
Other
Eligibility
20 Years to 40 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 2, 2026, 1:28 AM EDT
Terminated Phase 2 Interventional

Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids

NCT01821430
View directory record Official record
Conditions
Chronic Pain
Interventions
Pregabalin, Placebo
Drug
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional

Mechanisms of Palmitoylethanolamide (PEA) to Alter Pain Sensitivity in Knee Osteoarthritis

NCT05406726
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
palmitoylethanolamide, Placebo
Dietary Supplement
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
40 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 4, 2024 · Synced Sep 2, 2026, 1:28 AM EDT
Completed No phase listed Observational

Role of B2 Adrenergic Receptors in Labor Pain

NCT00385294
View directory record Official record
Conditions
Pain, Pain Threshold, Labour Pain
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 2, 2026, 1:28 AM EDT
Completed No phase listed Observational

Effect of Chemotherapy on Pain Sensitivity and Patient-reported Symptoms

NCT01983982
View directory record Official record
Conditions
Breast Cancer, Chronic Pain
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 25, 2016 · Synced Sep 2, 2026, 1:28 AM EDT
Completed No phase listed Observational

Effect of Spinal Cord Stimulation on Pain Thresholds and Sensory Perception in Chronic Pain Patients.

NCT01137617
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2020 · Synced Sep 2, 2026, 1:28 AM EDT
Not yet recruiting Phase 2 Interventional

A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder

NCT06710431
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Abuse/addiction, Anxiety, Pain Threshold, Depression Disorders, Sleep Disorder
Interventions
AFA-281
Drug
Lead sponsor
Afasci Inc
Industry
Eligibility
21 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2024 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

NCT03344913
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain, Physical Activity, Mitochondrial Pathology
Interventions
Walking
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 6, 2022 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold

NCT02550093
View directory record Official record
Conditions
Healthy
Interventions
Intervention 1, Washout Period, Intervention 2
Procedure · Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
20 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 15, 2022 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Prophylactic Massage Therapy on Pain Tolerance and Threshold

NCT04625335
View directory record Official record
Conditions
Pain
Interventions
No Massage Protocol, Prophylactic Therapeutic Massage
Other
Lead sponsor
Kyle Knight
Other
Eligibility
18 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Phase 2 Interventional Results available

Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception

NCT00351819
View directory record Official record
Conditions
Pain, Hypogonadism
Interventions
AndroGel, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 100 Years · Male only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Sep 2, 2026, 1:28 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Oxytocin and Pain Sensitivity and Threshold

NCT01988649
View directory record Official record
Conditions
Pain
Interventions
Intranasal Oxytocin, Placebo (saline)
Drug
Lead sponsor
Northwestern University
Other
Eligibility
20 Years to 35 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 7, 2017 · Synced Sep 2, 2026, 1:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Participant(s) With Autism and High Pain Tolerance Treated With High Dose Naltrexone

NCT05100563
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
50 mg naltrexone
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
12 Years to 80 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 2, 2026, 1:28 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

NCT01222091
View directory record Official record
Conditions
Hyperalgesia
Interventions
Propranolol, Placebo to Match Propranolol, Remifentanil
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Sep 2, 2026, 1:28 AM EDT