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ClinicalTrials.gov public records Last synced Oct 1, 2026, 9:30 PM EDT

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Showing 25–48 of 354 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain and Anxiety Clear all
Completed Phase 2 Interventional Results available

Treating Negative Affect in Low Back Pain Patients

NCT04747314
View directory record Official record
Conditions
Chronic Low Back Pain, Negative Affectivity
Interventions
Antidepressant, Enhanced Fear Avoidance Rehabilitation
Drug · Other
Lead sponsor
Ajay Wasan, MD, Msc
Other
Eligibility
18 Years to 75 Years
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Chestnut Hill, Massachusetts • Rochester, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional Results available

Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications

NCT04419168
View directory record Official record
Conditions
Chronic Pain, Depression, Anxiety, Opioid Use
Interventions
cCBT, m-Education
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
7
States / cities
Chicago, Illinois • Baltimore, Maryland • Durham, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

Does Distraction With a Hand Held Video Game Reduce Preoperative and Emergence Anxiety in Children?

NCT00932685
View directory record Official record
Conditions
Pediatric Emergence Agitation and Pain
Interventions
Midazolam, Game Boy
Drug · Device
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
4 Years to 12 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 3, 2009 · Synced Oct 1, 2026, 9:30 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

PURSUIT: A Technologically Augmented School-based Program to Improve Child Coping and Prevent Substance Use.

NCT07266740
View directory record Official record
Conditions
Pediatric Pain, Anxiety, Mood, Stress, Feasibility Studies, Acceptability, Health Promotion, Online Mental Health Program
Interventions
PURSUIT
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
8 Years to 18 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 1, 2026, 9:30 PM EDT
Active, not recruiting Not applicable Interventional

App Delivered Brief Mindfulness Intervention for Surgical Patients

NCT05433389
View directory record Official record
Conditions
Pain, Anxiety State, Depressive State
Interventions
Breath Counting, Body Scan, Mindful Breathing, Mindfulness of Pain, Mindful Savoring
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
823 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

Wellness Through Mobile Health

NCT04640090
View directory record Official record
Conditions
Musculoskeletal Diseases, Chronic Pain, Anxiety Disorders, Depression
Interventions
Smartphone app (Wysa)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 1, 2021 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy

NCT02445378
View directory record Official record
Conditions
Acute Leukemia, Anorexia, Anxiety, Depression, Dyspnea, Insomnia, Nausea, Pain
Interventions
Aromatherapy and Essential Oils, Placebo, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Not listed
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 5, 2019 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Music on Nociceptive Processing

NCT04087564
View directory record Official record
Conditions
Pain, Acute, Pain, Chronic, Anxiety, Anxiety Disorders, Catastrophization, Healthy
Interventions
music intervention
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality for the Management of Pain and Anxiety for Outpatient Interventional Radiology Procedures

NCT06150963
View directory record Official record
Conditions
Pain, Anxiety
Interventions
Virtual Reality, Standard Procedure Thyroid Biopsy, Standard Procedure PICC Placement
Device · Procedure
Lead sponsor
Temple University
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 1, 2026, 9:30 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of State and Trait Anxiety on Pain-pressure Threshold

NCT06047704
View directory record Official record
Conditions
Pain, Anxiety, Musculoskeletal Pain, Sensitisation
Interventions
No intervention
Other
Lead sponsor
Philadelphia College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Goggle Utilization for Venipuncture Distraction

NCT04479735
View directory record Official record
Conditions
Pain, Procedural
Interventions
Virtual Reality Goggles
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
5 Years to 21 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 1, 2026, 9:30 PM EDT
Not listed Not applicable Interventional

Massage Therapy After Thoracic or Lumbar Surgery

NCT06424158
View directory record Official record
Conditions
Scoliosis; Adolescence, Adolescent Idiopathic Scoliosis, Thoracic Region, Adolescent Idiopathic Scoliosis, Lumbar Region
Interventions
Massage Therapy
Other
Lead sponsor
Cook Children's Health Care System
Other
Eligibility
7 Years to 19 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Mood in Assisted Living Settings

NCT01763216
View directory record Official record
Conditions
Depressive Symptoms, Clinical Depression
Interventions
Road Tour, Boatload of Crosswords
Other
Lead sponsor
Marianne Smith
Other
Eligibility
55 Years and older
Enrollment
351 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
32
States / cities
Amana, Iowa • Bettendorf, Iowa • Carlisle, Iowa + 17 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2020 · Synced Oct 1, 2026, 9:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Aromatherapy and Its Impact on Preoperative Anxiety, Postoperative Pain, and Patient Experience

NCT07771205
View directory record Official record
Conditions
Postoperative Pain, Preoperative Anxiety, Patient Experience
Interventions
Aromatherapy, Unscented Pod
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
286 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stockton, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

The Impact of Simulated Forest Immersion Therapy on Pain and Anxiety in Patients Axial Spondyloarthritis (axSpA)

NCT06072859
View directory record Official record
Conditions
Axial Spondyloarthritis
Interventions
Humidified Forest Oils, Forest oils and audio-visual forest exposure
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 1, 2026, 9:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Health in Rural Populations: Music as Therapy

NCT07538427
View directory record Official record
Conditions
Stress, Generalized Anxiety, Chronic Pain, Depression Disorder
Interventions
Music Based Intervention
Behavioral
Lead sponsor
Northern Arizona University
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety

NCT01182051
View directory record Official record
Conditions
Pediatric, Headache, Anxiety
Interventions
CBT or relaxation training
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
7 Years to 17 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 24, 2013 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure

NCT04935775
View directory record Official record
Conditions
Pain, Acute, Anxiety
Interventions
Untrained Touch
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional Results available

Decreasing Delirium Through Music in Critically Ill Older Adults

NCT04182334
View directory record Official record
Conditions
Intensive Care Unit Delirium, Pain, Anxiety, Intensive Care Acquired Cognitive Impairment
Interventions
Slow Tempo Music, Attention Control
Other
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
5
States / cities
Avon, Indiana • Indianapolis, Indiana • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 1, 2026, 9:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study

NCT04653064
View directory record Official record
Conditions
Pain
Interventions
Placebo Cream, Control Cream
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Hanover, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

Virtual Reality, Debriefing and Chronic Pain

NCT05254509
View directory record Official record
Conditions
Chronic Pain
Interventions
Occupational Therapy, Occupational Therapy +Virtual Reality
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Oct 1, 2026, 9:30 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management

NCT04729244
View directory record Official record
Conditions
CBD, Pain, Chronic, Anxiety, Insomnia, Opioid Use
Interventions
CBD
Drug
Lead sponsor
Advanced Pain and Rehab Specialists
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hermitage, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 1, 2026, 9:30 PM EDT
Completed Not applicable Interventional

Determining the Efficacy of Essential Oil Aromatherapy in Children Undergoing Port Access

NCT05696899
View directory record Official record
Conditions
Anxiety and Fear, Pain
Interventions
STILL QuickTAB Medipack blended scent aromatherapy, manufactured by Soothing Scents
Other
Lead sponsor
Stanford University
Other
Eligibility
4 Years to 18 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 1, 2026, 9:30 PM EDT
Enrolling by invitation Not applicable Interventional

Exploring the Effect of Aromatherapy

NCT07155876
View directory record Official record
Conditions
Anxiety, Labor Pain, Nausea and Vomiting
Interventions
Aromatherapy plus standard of care, Standard of Care Only
Other
Lead sponsor
Baptist Health South Florida
Other
Eligibility
18 Years and older · Female only
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 1, 2026, 9:30 PM EDT