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ClinicalTrials.gov public records Last synced Oct 10, 2026, 12:22 AM EDT

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Showing 97–120 of 125 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Paroxysmal Atrial Fibrillation (PAF) Clear all
Active, not recruiting No phase listed Observational

STOP AF First Post-Approval Study

NCT05227053
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Arctic Front™ Cardiac Cryoablation Catheter
Device
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
11
States / cities
Anchorage, Alaska • Stamford, Connecticut • Washington D.C., District of Columbia + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 10, 2026, 12:22 AM EDT
Not listed Phase 2Phase 3 Interventional

Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation

NCT00691470
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Flutter, Venous Thromboembolic Disease, Myocardial Infarction, Cardiomyopathy
Interventions
ATI-5923, Coumadin (warfarin)
Drug
Lead sponsor
ARYx Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
41
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 34 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2010 · Synced Oct 10, 2026, 12:22 AM EDT
Recruiting Not applicable Interventional

Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

NCT07298473
View directory record Official record
Conditions
Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
Interventions
Sphere-9 Catheter Ablation
Device
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
22
States / cities
Birmingham, Alabama • La Jolla, California • Los Angeles, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated Not applicable Interventional

Focal Impulse and Rotor Modulation Ablation Trial for Treatment of Paroxysmal Atrial Fibrillation (FIRMAT-PAF)

NCT01925885
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
PVI Ablation, FIRM Ablation
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Oct 10, 2026, 12:22 AM EDT
Active, not recruiting Not applicable Interventional

Treatment of PAF With the Synaptic System

NCT05905835
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Synaptic Cryoablation System
Device
Lead sponsor
Synaptic Medical Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
10
States / cities
Phoenix, Arizona • Jonesboro, Arkansas • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional

A Study of the THERMOCOOL SMARTTOUCH Surround Flow (SF) Catheter With the TRUPULSE Generator for Treatment of Drug Refractory Symptomatic PAF

NCT06144632
View directory record Official record
Conditions
Drug Refractory Paroxysmal Atrial Fibrillation
Interventions
THERMOCOOL STSF Bi- Directional Navigation Catheter, TRUPULSE Generator
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Atlantis, Florida + 24 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated Not applicable Interventional Results available

ECGi Ibutilide: Effect of Ibutilide on AF Source Location and Organization

NCT03370536
View directory record Official record
Conditions
Atrial Fibrillation, Persistent Atrial Fibrillation
Interventions
CardioInsight ECGI Mapping System, AF ablation, Ibutilide
Device · Procedure · Drug
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated Not applicable Interventional

Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation

NCT04216667
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Catheter ablation
Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
10
States / cities
Birmingham, Alabama • Larkspur, California • Boulder, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional

A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:

NCT06676072
View directory record Official record
Conditions
Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
Interventions
PFA Ablation catheter
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
29
States / cities
Scottsdale, Arizona • Little Rock, Arkansas • Stanford, California + 24 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 10, 2026, 12:22 AM EDT
Completed No phase listed Observational

RHYTHMIA vs CARTO in Redo Ablation Procedures for Atrial Fibrillation

NCT04835844
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
CARTO, RHYTHMIA
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation in Subjects With Paroxysmal Atrial Fibrillation

NCT03775512
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
RF Ablation with QDOT Micro
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
18 Years and older
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
22
States / cities
Birmingham, Alabama • Atlantis, Florida • Jacksonville, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Oct 10, 2026, 12:22 AM EDT
Recruiting Not applicable Interventional

Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation

NCT06754176
View directory record Official record
Conditions
Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal)
Interventions
Alcohol Consumption Randomized Instructions
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Phase 3 Interventional

Cryoballoon Ablation of Pulmonary Veins After Failed RF Ablation in Patients With Paroxysmal AF

NCT01611701
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
cryoballoon ablation, Radiofrequency ablation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2012 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated Phase 2 Interventional Results available

The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure

NCT01887353
View directory record Official record
Conditions
Atrial Fibrillation, Heart Failure
Interventions
Ranolazine, Placebo
Drug
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jul 20, 2015 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated No phase listed Observational

DIAMOND AF Post-Approval Study

NCT05230524
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
DiamondTemp™ Ablation System
Device
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Winter Park, Florida
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated Phase 1 Interventional Results available

Ascending Dose Study of OPC-108459 Intravenous Infusions in Patients With Paroxysmal and Persistent Atrial Fibrillation

NCT01483183
View directory record Official record
Conditions
Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Interventions
OPC-108459, Placebo
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
9
States / cities
Washington D.C., District of Columbia • Hollywood, Florida • Jacksonville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Occult Paroxysmal Atrial Fibrillation in Non-Cryptogenic Ischemic Stroke

NCT02232022
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Reveal LINQ Insertable Cardiac Monitor
Device
Lead sponsor
Northwell Health
Other
Eligibility
41 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Manhasset, New York • New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional

The OneFreeze Study

NCT02217254
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Atrial fibrillation catheter ablation using the Medtronic Arctic Front Ablation System
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
San Francisco, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation

NCT03118518
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Fibrillation New Onset
Interventions
Cryoablation, Antiarrhythmic drug
Device · Drug
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years to 80 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
24
States / cities
Birmingham, Alabama • Anchorage, Alaska • Newport Beach, California + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Phase 2 Interventional Results available

Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation

NCT00971204
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
CardioFocus HeartLight Endoscopic Ablation System
Device
Lead sponsor
CardioFocus
Industry
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
10
States / cities
Birmingham, Alabama • Santa Monica, California • Royal Oak, Michigan + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2016 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation

NCT00584415
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
GP ablation + PV isolation
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 28, 2014 · Synced Oct 10, 2026, 12:22 AM EDT
Terminated Not applicable Interventional

MultiPulse Therapy (MPT) for AF (US)

NCT05055921
View directory record Official record
Conditions
Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Interventions
Multi Pulse Therapy as delivered from the Cardialen External Stimulation System
Device
Lead sponsor
Cardialen, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Minneapolis, Minnesota • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 10, 2022 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Phase 3 Interventional Results available

THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation CONTINUED ACCESS

NCT01639495
View directory record Official record
Conditions
Drug Refractory Symptomatic Paroxysmal Atrial Fibrillation
Interventions
THERMOCOOL® SMARTTOUCH™ Catheter
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
20
States / cities
Birmingham, Alabama • Stanford, California • Orlando, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Oct 10, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation

NCT01687166
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation (PAF)
Interventions
Blazer Open-Irrigated Ablation Catheter (Boston Scientific), FDA Approved Open-Irrigated Ablation Catheter
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
27
States / cities
Birmingham, Alabama • Huntsville, Alabama • Redwood City, California + 23 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2018 · Synced Oct 10, 2026, 12:22 AM EDT