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Showing 1–24 of 127 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Partial Deafness Clear all
Completed No phase listed Observational

Study of Usher Syndromes, Type 1 and Type 2

NCT00001347
View directory record Official record
Conditions
Retinitis Pigmentosa
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Not applicable Interventional

Auditory Neural Function in Implanted Patients With Usher Syndrome

NCT04906135
View directory record Official record
Conditions
Usher Syndrome, Cochlear Implantation
Interventions
Experimental manipulation of stimulation parameters
Other
Lead sponsor
Ohio State University
Other
Eligibility
1 Year to 85 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Boston, Massachusetts • Columbus, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Sep 8, 2026, 5:54 AM EDT
Active, not recruiting Not applicable Interventional

Pivotal Clinical Trial Evaluating the Safety and Efficacy of the Fully Implanted Acclaim Cochlear Implant

NCT06699797
View directory record Official record
Conditions
Sensori-Neural Deafness, Sensorineural Hearing Loss, Sensorineural Hearing Loss (Disorder), Sensorineural Hearing Loss, Bilateral, Sensorineural Hearing Loss, Profound, Sensorineural Hearing Loss, Severe
Interventions
Acclaim Cochlear Implant
Device
Lead sponsor
Envoy Medical Corporation
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
7
States / cities
Tucson, Arizona • Seal Beach, California • Gainesville, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Not applicable Interventional

Hearing Outcomes With the Osia 3 Sound Processor Compared to the Osia 2 Sound Processor in Adult Osia Implant Recipients

NCT07156461
View directory record Official record
Conditions
Hearing Loss, Mixed, Hearing Loss, Conductive, Single-Sided Deafness, Bone Conduction
Interventions
Cochlear™ Osia® System (Osia® 2), Cochlear™ Osia® System (Osia® 3)
Device
Lead sponsor
Cochlear
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cochlear Implants in Young Children With SSD

NCT05775367
View directory record Official record
Conditions
Single Sided Deafness, Unilateral Deafness, Hearing Loss, Unilateral, Hearing Loss, Congenital Hearing Loss, Deafness One Ear
Interventions
Cochlear Implant
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
7 Months to 71 Months
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Phase 3 Interventional Results available

Sudden Deafness Treatment Trial

NCT00097448
View directory record Official record
Conditions
Sudden Deafness
Interventions
prednisone, methylprednisolone sodium succinate
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
14
States / cities
Los Angeles, California • San Diego, California • Gainesville, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 8, 2026, 5:54 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

NCT05158296
View directory record Official record
Conditions
Retinitis Pigmentosa, Usher Syndrome Type 2, Deaf Blind, Retinal Disease, Eye Diseases, Eye Diseases, Hereditary, Eye Disorders Congenital, Vision Disorders
Interventions
Ultevursen, Sham-procedure
Drug · Other
Lead sponsor
Laboratoires Thea
Industry
Eligibility
12 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
10
States / cities
San Diego, California • San Francisco, California • Miami, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Otoprotection With SPI-1005 for Prevention of Temporary Auditory Threshold Shift

NCT01444846
View directory record Official record
Conditions
Temporary Auditory Threshold Shift
Interventions
SPI-1005 Low dose, SPI-1005 Middle dose, SPI-1005 High dose, Placebo
Drug
Lead sponsor
Sound Pharmaceuticals, Incorporated
Industry
Eligibility
18 Years to 31 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Maintaining Cochlear Patency After VIIIth Nerve Surgery

NCT03261726
View directory record Official record
Conditions
Acoustic Neuroma, Labyrinthitis Ossificans, Profound Hearing Impairment
Interventions
MedEl Test Electrode Placer
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Farmington Hills, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of a New Implant System for Bone Conduction Hearing

NCT03086135
View directory record Official record
Conditions
Deafness; Sensoneural Single Sided, Conductive Hearing Loss, Mixed Hearing Loss
Interventions
Osia System
Device
Lead sponsor
Cochlear
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Sep 8, 2026, 5:54 AM EDT
Recruiting Not applicable Interventional

Cochlear Implant Speech in Noise Processing

NCT06860152
View directory record Official record
Conditions
Hearing Loss, Adult-Onset, Speech Intelligibility, Hearing Loss, Extreme
Interventions
Cochlear implant
Device
Lead sponsor
Craig D. Workman, PhD
Other
Eligibility
18 Years to 99 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Inherited Retinal Degenerative Disease Registry

NCT02435940
View directory record Official record
Conditions
Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome, Bassen-Kornzweig Syndrome, Batten Disease, Best Disease, Choroidal Dystrophy, Choroideremia, Cone Dystrophy, Cone-Rod Dystrophy, Congenital Stationary Night Blindness, Enhanced S-Cone Syndrome, Fundus Albipunctatus, Goldmann-Favre Syndrome, Gyrate Atrophy, Juvenile Macular Degeneration, Kearns-Sayre Syndrome, Leber Congenital Amaurosis, Refsum Syndrome, Retinitis Pigmentosa, Retinitis Punctata Albescens, Retinoschisis, Rod-Cone Dystrophy, Rod Dystrophy, Rod Monochromacy, Stargardt Disease, Usher Syndrome
Interventions
Not listed
Lead sponsor
Foundation Fighting Blindness
Other
Eligibility
Not listed
Enrollment
20,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2037
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Study of Dietary N-3 Fatty Acids in Patients With Retinitis Pigmentosa and Usher Syndrome

NCT00004345
View directory record Official record
Conditions
Usher Syndrome, Retinitis Pigmentosa
Interventions
Not listed
Lead sponsor
National Center for Research Resources (NCRR)
NIH
Eligibility
0 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1999
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 8, 2026, 5:54 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

NCT01694940
View directory record Official record
Conditions
Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes, Deletion and Duplication of Mitochondrial DNA
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2026
U.S. locations
16
States / cities
San Diego, California • Stanford, California • Aurora, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Recruiting Phase 1 Interventional

Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

NCT05241262
View directory record Official record
Conditions
Mitochondrial Disease
Interventions
N-Acetylcysteine
Drug
Lead sponsor
Michio Hirano, MD
Other
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Tracking Neurodegeneration in Early Wolfram Syndrome

NCT02455414
View directory record Official record
Conditions
Type 1 Diabetes, Diabetes Insipidus, Diabetes Mellitus, Wolfram Syndrome
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
1 Day and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 10, 2018 · Synced Sep 8, 2026, 5:54 AM EDT
Not yet recruiting Not applicable Interventional

Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants

NCT07081542
View directory record Official record
Conditions
Sensorineural Hearing Loss, Bilateral Hearing Loss, Cochlear Implantation, Hearing Disorders, Hearing Disorders and Deafness, Inner Ear Disorders, Hearing Impairment
Interventions
IotaSoft Robotic Insertion System, Manual Cochlear Implant Insertion
Device · Procedure
Lead sponsor
AdventHealth
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Kissimmee, Florida
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Cochlear Implantation in Children With Asymmetric Hearing Loss or Single-Sided Deafness Clinical Trial

NCT04793412
View directory record Official record
Conditions
Asymmetric Hearing Loss, Single-sided Deafness, Unilateral Deafness
Interventions
Cochlear Implant
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
4 Years to 14 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
5
States / cities
Los Angeles, California • Minneapolis, Minnesota • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 8, 2026, 5:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Genetic Testing in Detection of Late-Onset Hearing Loss

NCT00511381
View directory record Official record
Conditions
Hearing Loss, Late-Onset Hearing Loss, Deafness
Interventions
No intervention
Genetic
Lead sponsor
Pediatrix
Other
Eligibility
Up to 14 Days
Enrollment
3,681 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
3
States / cities
Topeka, Kansas • Dayton, Ohio • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 29, 2012 · Synced Sep 8, 2026, 5:54 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Comparing Site-selection Strategies

NCT03870217
View directory record Official record
Conditions
Deafness
Interventions
Site selection
Behavioral
Lead sponsor
East Carolina University
Other
Eligibility
15 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Phase 2 Interventional

Effectiveness of Therapy Via Telemedicine Following Cochlear Implants

NCT02497690
View directory record Official record
Conditions
Congenital Sensorineural Deafness
Interventions
Telemedicine, In-person ART
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
6 Months to 6 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 18, 2021 · Synced Sep 8, 2026, 5:54 AM EDT
Terminated Phase 2 Interventional Results available

Study to Evaluate the Safety and Activity of BB3 to Treat Heart Attack

NCT01539590
View directory record Official record
Conditions
Myocardial Infarction
Interventions
BB3, Normal saline
Drug
Lead sponsor
Angion Biomedica Corp
Industry
Eligibility
21 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Minneapolis, Minnesota • New Haven, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2014 · Synced Sep 8, 2026, 5:54 AM EDT
Completed No phase listed Observational

Single-sided Deafness and Cochlear Implantation

NCT05052944
View directory record Official record
Conditions
Hearing Loss, Hearing Loss, Sensorineural, Hearing Loss, Unilateral, Hearing Loss, Sudden, Hearing Loss, Cochlear, Hearing Loss in Left Ear, Hearing Loss in Right Ear, Labyrinthitis
Interventions
Cochlear implantation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Bethesda, Maryland • Lutherville-Timonium, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2023 · Synced Sep 8, 2026, 5:54 AM EDT
Completed Not applicable Interventional Results available

Cochlear Implantation in Cases of Single-Sided Deafness

NCT02203305
View directory record Official record
Conditions
Unilateral Moderate to Profound Hearing Loss, Asymmetric Hearing Loss, Single-Sided Deafness (SSD)
Interventions
Cochlear Implant, Control Group
Device · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 24, 2022 · Synced Sep 8, 2026, 5:54 AM EDT