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ClinicalTrials.gov public records Last synced Nov 8, 2026, 8:52 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 649–672 of 3,978 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Pathophysiology Clear all

Conditions: Aging, Cognitive Decline, Mild Cognitive Impairment, Dementia, Hearing Loss
Interventions: Hearing intervention, Successful aging/delayed hearing intervention; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 73 Years and older
Enrollment: 629 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 4
States / cities: Hagerstown, Maryland • Minneapolis, Minnesota • Jackson, Mississippi + 1 more

Conditions: Alzheimer Disease, Mild Cognitive Impairment, Neuropsychiatric Symptoms, Sleep Disturbance
Interventions: Cognitive Behavioral Therapy for Insomnia (CBT-I), Desensitization Therapy for insomnia (DT-I); Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 50 Years to 90 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma, Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma, Metastatic Malignant Solid Neoplasm, Stage III Hepatocellular Carcinoma AJCC v7, Stage IIIA Hepatocellular Carcinoma AJCC v7, Stage IIIB Hepatocellular Carcinoma AJCC v7, Stage IIIC Hepatocellular Carcinoma AJCC v7, Stage IV Hepatocellular Carcinoma AJCC v7, Stage IVA Hepatocellular Carcinoma AJCC v7, Stage IVB Hepatocellular Carcinoma AJCC v7, Unresectable Solid Neoplasm
Interventions: Laboratory Biomarker Analysis, Pharmacological Study, Tazemetostat; Other · Drug
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cognitive Decline
Interventions: ProdromeNeuro Omega 3 Oil Nutritional Supplement; Dietary Supplement
Lead sponsor: Neurological Associates of West Los Angeles; Other
Eligibility: 35 Years to 65 Years · Male only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Alzheimer Disease
Interventions: Empagliflozin, Insulin, Insulin Placebo, Empagliflozin Placebo; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 55 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Non-Alcoholic Fatty Liver Disease, Steatosis of Liver, Metabolic Dysfunction-Associated Steatotic Liver Disease
Interventions: STIRRED; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 4,704 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: COVID-19, Muscle Atrophy, Muscle Weakness
Interventions: Electrical Stimulation, Electrical Stimulation - Sham; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 100 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Chemotherapy-induced Cognitive Impairment
Interventions: Neurocognitive assessments; Behavioral
Lead sponsor: Rachel Miller; Other
Eligibility: 18 Years and older · Female only
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Osteoarthritis, Knee, Dementia
Interventions: Tai Chi, Attention control; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 60 Years and older
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Parkinson Disease
Interventions: Gen0Bh Transcranial Focused Ultrasound System (Active), Gen0Bh Transcranial Focused Ultrasound System (Sham); Device
Lead sponsor: Sanmai Technologies PBC dba Sanmai; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 4
States / cities: Tucson, Arizona • Santa Monica, California • Gainesville, Florida + 1 more

Conditions: Mild Cognitive Impairment, Alzheimer's Disease
Interventions: Flutemetamol (18F) Injection; Drug
Lead sponsor: GE Healthcare; Industry
Eligibility: 60 Years and older
Enrollment: 365 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Princeton, New Jersey

Conditions: Liver Dysfunction
Interventions: liver biopsy; Procedure
Lead sponsor: University of Alberta; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2028
U.S. locations: 8
States / cities: San Francisco, California • Chicago, Illinois • Baltimore, Maryland + 5 more

Conditions: Sodium Excess
Interventions: High Sodium, Placebo; Dietary Supplement · Other
Lead sponsor: University of Delaware; Other
Eligibility: 21 Years to 45 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Blepharitis, Dry Eye Syndrome
Interventions: LipiFlow Pre-Treatment, LipiFlow Post-treatment; Device
Lead sponsor: TearScience, Inc.; Industry
Eligibility: 55 Years to 85 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 7
States / cities: Hoffman Estates, Illinois • Lake Villa, Illinois • Winchester, Massachusetts + 4 more

Conditions: Congestive Heart Failure
Interventions: Avandia (Rosiglitazone), Avanclia (Rosiqlitazone); Drug
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2007
U.S. locations: 2
States / cities: Bethesda, Maryland

Conditions: Postoperative Cognitive Dysfunction
Interventions: Not listed
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 60 Years to 80 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Alcohol Aftereffects, Anxiety, Cognitive Impairment
Interventions: JoyRise Recovery Powder, Placebo; Dietary Supplement
Lead sponsor: Joyrise; Industry
Eligibility: 35 Years to 54 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Chronic Lung Allograft Dysfunction Lung MRI (CLAD)
Interventions: Spirometry, Contrast Lung Computed Tomography (CT) Scan, Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan, 129Xe MRI scans; Diagnostic Test · Drug
Lead sponsor: Sean Fain; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Mild Cognitive Impairment
Interventions: Aerobic exercise, Stretching; Behavioral
Lead sponsor: University of Delaware; Other
Eligibility: 60 Years to 90 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Obesity, Vascular Dysfunction
Interventions: Exercise training; Other
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years to 50 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Skin Barrier Dysfunction, Healthy Volunteers
Interventions: Fermented Papaya Preparation (FPP); Dietary Supplement
Lead sponsor: University of Pittsburgh; Other
Eligibility: 50 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cognitive Impairment, Elderly
Interventions: 2g Centella asiatica water extract product, 4g Centella asiatica water extract product; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 65 Years to 85 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Periodontal Disease, Atherosclerosis
Interventions: Not listed
Lead sponsor: San Diego State University; Other
Eligibility: 21 Years to 40 Years
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Valley Center, California

Conditions: Spinal Cord Injuries
Interventions: Heated Vest, Non-Heated Vest; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 68 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: The Bronx, New York

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ACHIEVE Brain Health Follow-Up Study

Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia

Tazemetostat in Treating Patients With Metastatic or Unresectable Solid Tumors or B-Cell Lymphomas With Liver Dysfunction

Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline

Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's Disease

Improving Diagnostic Safety Through STeatosis Identification, Risk Stratification, and Referral in the ED

Electrical Stimulation for Critically Ill Post-Covid-19 Patients

Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients

Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia

Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics

Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery

Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes

Use of Brain Wave Monitoring During Surgery to Reduce Postoperative Cognitive Dysfunction

A Clinical Study to Assess the Effects of JoyRise Recovery Powder on Mitigating Alcohol Aftereffects.

Chronic Lung Allograft Dysfunction MRI Study

Aging Brain Structure and Memory in Response to Exercise

DNA Methylation and Vascular Function

Effect of FPP on Cutaneous Barrier Integrity

Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment

Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults

Heated Vest for Persons With Spinal Cord Injury