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ClinicalTrials.gov public records Last synced Nov 10, 2026, 7:11 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2209–2232 of 3,979 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Pathophysiology Clear all

Conditions: ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19, Chronic Fatigue, Chronic Fatigue Syndrome (CFS), Brain Fog, Cognitive Impairment, Cognitive Dysfunction
Interventions: Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package, Follow Up Phone Calls, Trans-auricular Vagus Nerve Stimulation: High Intensity, In-session Brain Health Training, Reaction Time Training, Trans-auricular Vagus Nerve Stimulation: Low Intensity; Behavioral · Procedure
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Diabetic Vascular Complications
Interventions: Not listed
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Mineola, New York

Conditions: Meibomian Gland Dysfunction, Evaporative Dry Eye Disease
Interventions: Systane iLux® Dry Eye System, LipiFlow® Thermal Pulsation System; Device
Lead sponsor: Alcon Research; Industry
Eligibility: 18 Years and older
Enrollment: 299 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 15
States / cities: Long Beach, California • Los Angeles, California • San Diego, California + 12 more

Conditions: Down Syndrome, Cognitive Dysfunction
Interventions: Aricept (Donepezil hydrochloride), Placebo; Drug
Lead sponsor: Eisai Inc.; Industry
Eligibility: 6 Years to 10 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 2
States / cities: San Antonio, Texas • Herndon, Virginia

Conditions: Breast Cancer, Cognitive/Functional Effects, Fatigue, Long-term Effects Secondary to Cancer Therapy in Adults
Interventions: assessment of therapy complications, cognitive assessment, fatigue assessment and management; Procedure
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Cleveland, Ohio

Conditions: Alzheimer Disease, Mild Cognitive Impairment, Cognitive Change, Energy Metabolism, Sleep Disturbance
Interventions: MyTAP oral appliance plus mouth shield; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 55 Years to 85 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Head and Neck Cancer, Neck Dissection
Interventions: Spinal Accessory Nerve Protection utilizing Axoguard HA+; Device
Lead sponsor: Matthew Spector; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cognitive Decline
Interventions: Brain exercise gameplay on a portable electronic device; Device
Lead sponsor: Ohio State University; Other
Eligibility: 60 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Neurogenic Urinary Bladder
Interventions: Alfuzosin, Placebo; Drug
Lead sponsor: Sanofi; Industry
Eligibility: 2 Years to 16 Years
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Bridgewater, New Jersey

Conditions: Childhood Cancer, Cancer Survivors
Interventions: POWERbreathe Plus IMT; Device
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 6 Years to 12 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Contact Lens Discomfort, Meibomian Gland Dysfunction
Interventions: BlephEx, Manual debridement; Device
Lead sponsor: University of the Incarnate Word; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Aging, Aging Well, All-Cause Mortality, Mortality, Metabolic Syndrome, Cardiovascular Diseases, Cognitive Dysfunction, Musculoskeletal Diseases, Neoplasms, Frailty, Activities of Daily Living, Health-Related Quality of Life, Disability Physical, Neuro-Degenerative Disease, Dementia
Interventions: Comprehensive Multi-System Clinical Screening; Diagnostic Test
Lead sponsor: Longevity Metrics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 1,000,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2099
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Chronic Ischemic Heart Disease, Left Ventricular Dysfunction, Angina, Ischemic Cardiomyopathy
Interventions: Adult stem cells, Placebo; Biological
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 5
States / cities: Gainesville, Florida • Minneapolis, Minnesota • Cleveland, Ohio + 2 more

Conditions: Preclinical Alzheimer's Disease
Interventions: Gemfibrozil, Placebo; Drug
Lead sponsor: Gregory Jicha, 323-5550; Other
Eligibility: 65 Years to 90 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Blood Pressure, Endothelial Dysfunction, Hypertension
Interventions: Inspiratory muscle strength training, Brisk walking; Other
Lead sponsor: University of Colorado, Boulder; Other
Eligibility: 50 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Erectile Dysfunction
Interventions: Platelet rich plasma, Placebo Sham Injection; Biological · Other
Lead sponsor: University of Nebraska; Other
Eligibility: 50 Years to 80 Years · Male only
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Nasal Airway Obstruction
Interventions: Vivaer ARC Stylus, Sham; Device
Lead sponsor: Aerin Medical; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 12
States / cities: Roseville, California • Torrance, California • Coral Springs, Florida + 9 more

Conditions: Major Depressive Disorder (MDD)
Interventions: Extended-release Bupropion Hydrochloride; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 425 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 24
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Berkeley, California + 19 more

Conditions: Cognitive Dysfunction
Interventions: iomazenil; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 45 Years
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2018
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Prediabetes, Obesity
Interventions: Exenatide, Saxagliptin, Exenatide extended-release (ER), Placebo; Drug · Other
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 30 Years to 70 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cancer, Bowel Dysfunction
Interventions: alvimopan, placebo; Drug
Lead sponsor: Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA); Industry
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 14
States / cities: Duarte, California • Fountain Valley, California • La Verne, California + 11 more

Conditions: Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
Interventions: Not listed
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cancer Survivor, Cognitive/Functional Effects, Leukemia, Long-term Effects Secondary to Cancer Therapy in Children, Lymphoma, Psychosocial Effects of Cancer and Its Treatment
Interventions: educational intervention, psychosocial assessment and care; Other · Procedure
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 6 Years to 16 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Duarte, California

Conditions: Alzheimer's Disease
Interventions: Not listed
Lead sponsor: Orasi Medical, Inc.; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Plymouth, Minnesota

Search by objective public record fields.

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

Continuous Glucose Monitoring in Type 2 Diabetes Mellitus

Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multicenter Study

Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10

Fatigue Caused by Chemotherapy in Women Who Have Undergone Surgery for Breast Cancer and in Healthy Volunteers

Brain Energy Metabolism and Sleep in Adults

Axoguard HA Plus Nerve Protector to Reduce Post-operative Neck and Shoulder Dysfunction in Patients Undergoing Neck Dissection

Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study

Alfuzosin Treatment in Children and Adolescents With Neurogenic Urinary Bladder Dysfunction

Diaphragm Structure and Function in Childhood Cancer Survivors

Meibomian Gland Dysfunction Management

100-Year Human Aging Study

Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)

Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease

Novel Time-efficient Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure

The Role of Platelet Rich Plasma for Erectile Dysfunction

Vivaer® Procedure for Treatment of Nasal Airway Obstruction Study

Effects Of Antidepressants On Sexual Functioning In Adults

GABA-glutamate Interactions and Psychosis

Effects of Antidiabetic Medications on the Postprandial State in Prediabetes

Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects

The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

Educational and Skills Training Program for Parents of Childhood Cancer Survivors Who Have Neurobehavioral Dysfunction

Improved Diagnosis of Alzheimer's Disease Using the Synchronous Neural Interaction™ Test