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ClinicalTrials.gov public records Last synced Oct 1, 2026, 8:33 AM EDT

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Showing 25–48 of 102 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Patient Comfort Clear all
Not yet recruiting Not applicable Interventional

The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage

NCT07223866
View directory record Official record
Conditions
Cataract and IOL Surgery, Cataract Surgery Anesthesia, Cataract Surgery Experience, Nuclear Cataract
Interventions
High IOP Setting, Low IOP Setting
Device
Lead sponsor
Matthew Rauen
Other
Eligibility
60 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Phase 4 Interventional

Comfort and Cleaning Evaluation of Multipurpose Solutions in Contact Lens Patients

NCT00519948
View directory record Official record
Conditions
Patient Comfort, Lens Cleanliness
Interventions
new MPS, opti-free express no rub MPS
Drug
Lead sponsor
Innovative Medical
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Timeline
Ends 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 19, 2008 · Synced Oct 1, 2026, 8:33 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Microderm for Root Coverage Procedures

NCT07203326
View directory record Official record
Conditions
Connective Tissue Graft, Gum Recession
Interventions
Alloderm, MicroDerm
Biological
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 1, 2026, 8:33 AM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers

Techniques to Enhance Patient Comfort in Sedation-risk Free Colonoscopy

NCT01076907
View directory record Official record
Conditions
Screening of Colonic Polyps
Interventions
Warm water, Control
Other
Lead sponsor
VA Greater Los Angeles Healthcare System
Federal
Eligibility
18 Years to 95 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 15, 2015 · Synced Oct 1, 2026, 8:33 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Comparison of Sequential Compression Devices and Foot Pumps in the Obstetric Population

NCT00356434
View directory record Official record
Conditions
Thrombophilia
Interventions
Kendall A-V foot impulse pump, model 6060, Kendall sequential compression device, model 9525
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2017 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer

NCT02191969
View directory record Official record
Conditions
Colorectal Cancer, Fatigue
Interventions
Walk With Ease
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
60 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 1, 2020 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Walk With Ease Program For Patients With Systemic Lupus Erythematosus

NCT02631005
View directory record Official record
Conditions
Systemic Lupus Erythematosus
Interventions
"Walk With Ease"
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Trial of Written Exposure for Metastatic Cancer Patients (EASE)

NCT06042400
View directory record Official record
Conditions
Metastatic Cancer, Solid Tumor Cancer, Lymphoproliferative Disorders, Anxiety, Post-traumatic Stress Symptoms, Fear of Cancer Progression
Interventions
Written Exposure Therapy
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Vapocoolant (Pain Ease Medium Stream) for Intravenous Lines in Emergency Department Patients

NCT01670487
View directory record Official record
Conditions
Pain
Interventions
Vapocoolant, Sterile water
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study to Evaluate Patient Tolerance and Nursing Ease-of-Use of a Novel Hearing Protection Device

NCT02744066
View directory record Official record
Conditions
Hearing Impairment
Interventions
NEATCAP
Device
Lead sponsor
Michael Balsan, MD
Other
Eligibility
12 Hours to 2 Weeks
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

GenTeal in Perioperative Treatment of Laser Assisted in Situ Keratomileusis LASIK Patients

NCT00598689
View directory record Official record
Conditions
Corneal Epithelium Defect
Interventions
0.3% hypromellose
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort

NCT02015221
View directory record Official record
Conditions
Chronic Venous Insufficiency
Interventions
Dual Action Pneumatic Compression Device, Standard Compression Garments
Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
11
States / cities
Phoenix, Arizona • Colton, California • La Jolla, California + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2016 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

To Evaluate the Performance of Total 30 (Lehifilcon A) Contact Lenses in Patients Using Digital Devices for Greater Than 8 Hours Per Day 5 Days Per Week Based on Subjective Reported Data.

NCT06317038
View directory record Official record
Conditions
Eye Strain
Interventions
Total 30 Contact Lens
Device
Lead sponsor
Tauber Eye Center
Other
Eligibility
18 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 1, 2026, 8:33 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Tetracaine Versus Lidocaine Gel for Anesthetic Effect and Comfort in Patients Undergoing LASIK

NCT01383200
View directory record Official record
Conditions
Pain
Interventions
Tetracaine drop, Lidocaine gel
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2017 · Synced Oct 1, 2026, 8:33 AM EDT
Not yet recruiting Not applicable Interventional

Pilot Study of MammoGRIP for Breast Positioning, Image Quality, and Patient Comfort in Mammography

NCT07388940
View directory record Official record
Conditions
Mammography
Interventions
MammoGRIP
Device
Lead sponsor
Englewood Hospital and Medical Center
Other
Eligibility
40 Years to 75 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Englewood, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Reduction of Claustrophobia and Patient Motion After Training of MRI Personnel in Comfort TalkTM

NCT01563198
View directory record Official record
Conditions
Claustrophobia, Complication of Diagnostic Procedure
Interventions
Comfort Talk®
Behavioral
Lead sponsor
Hypnalgesics, LLC
Industry
Eligibility
Not listed
Enrollment
97,712 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
4
States / cities
Boston, Massachusetts • Brookline, Massachusetts • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 14, 2017 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Patient Comfort Using Green vs. Yellow Pan Retinal Photocoagulation

NCT02995629
View directory record Official record
Conditions
Proliferative Diabetic Retinopathy - High Risk
Interventions
laser indirect ophthalmoscopy pan retinal photocoagulation
Procedure
Lead sponsor
Wills Eye
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2016 · Synced Oct 1, 2026, 8:33 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Assessing Patient Comfort With Two Different Multi-Purpose Disinfecting Solutions

NCT01847105
View directory record Official record
Conditions
Contact Lens Solution Toxicity
Interventions
RevitaLens, OptiFree PureMoist
Other
Lead sponsor
Hom, Milton M., OD, FAAO
Individual
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
3
States / cities
Azusa, California • Morrow, Georgia • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 1, 2026, 8:33 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Simulines Non-Inferiority Pivotal Study

NCT02736825
View directory record Official record
Conditions
Skin Laxity
Interventions
Ulthera System with standard transducer, Ulthera System with prototype 2 simulines transducer
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 70 Years
Enrollment
262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
8
States / cities
Beverly Hills, California • Roseville, California • Sacramento, California + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 1, 2026, 8:33 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Is Pain Ease (New Formula) Safe and Effective in Reducing Pain Associated With Peripheral Intravenous Cannulation (PIV)?

NCT07821476
View directory record Official record
Conditions
Peripheral Intravenous Cannulation, Pain Management
Interventions
Sterile water, Vapocoolant spray
Other · Device
Lead sponsor
Gebauer Company
Network
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 1, 2026, 8:33 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

SKED Physiology Study

NCT04964778
View directory record Official record
Conditions
Comparison of Patient Packaging and Transport Methods
Interventions
SKED©
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Oct 1, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure

NCT00727025
View directory record Official record
Conditions
Breast Hypertrophy, Abdominal Elastosis, Breast Reconstruction
Interventions
wound closure device (Steri-Strip™)
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Oct 1, 2026, 8:33 AM EDT
Withdrawn Not applicable Interventional

Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer

NCT03592459
View directory record Official record
Conditions
Advanced Malignant Neoplasm, Pain
Interventions
Macy Catheter, Pain Therapy, Questionnaire Administration, Survey Administration
Device · Procedure · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Oct 1, 2026, 8:33 AM EDT
Not listed Phase 4 Interventional

Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL

NCT04863742
View directory record Official record
Conditions
Dry Eye Syndromes
Interventions
Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
Drug
Lead sponsor
Sight Medical Doctors PLLC
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Brentwood, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 1, 2026, 8:33 AM EDT