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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:08 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Patients With Substance Abuse Clear all

Conditions: Peripheral Arterial Disease
Interventions: Bupivacaine liposome, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Eau Claire, Wisconsin

Conditions: Substance-Related Disorders
Interventions: Desipramine; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2001
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Compliance, Chronic Pain
Interventions: acetazolamide, Quinine, Riboflavin; Drug
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder
Interventions: Therabot-CALM; Device
Lead sponsor: Trustees of Dartmouth College; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
Interventions: MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing); Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Alcohol Abuse, Alcohol Dependence
Interventions: Motivational Interview, Assessment; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2011
U.S. locations: 2
States / cities: Providence, Rhode Island

Conditions: Substance Abuse, Substance Dependence, Substance, Addiction, Alcohol Abuse
Interventions: Linkage patient activation intervention; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 504 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Alcohol Abuse
Interventions: Protandim; Dietary Supplement
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years to 55 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Schizophrenia, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse, Alcohol Abuse
Interventions: Quetiapine; Drug
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 4
States / cities: Augusta, Georgia • Lebanon, New Hampshire • Manchester, New Hampshire

Conditions: Alcoholism, Alcohol Abuse, Hepatitis C, Liver Disease
Interventions: 3 session brief intervention with health behavior feedback, treatment as usual; Behavioral · Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Use Disorders, Substance Abuse, Substance Use, Substance Dependence
Interventions: The Bridge; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 99 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Bipolar Disorder, Major Depressive Disorder, Substance Abuse
Interventions: Pregnenolone; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Adolescent Substance Use
Interventions: Family Check-up, Parent psychoeducation; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 16 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Opioid-Related Disorders
Interventions: Video-based DOT Application; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Boston, Massachusetts • Seattle, Washington

Conditions: Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic, Opioid-use Disorder, Opioid Abuse and Addiction, Opioid Withdrawal
Interventions: Quality IQ Patient Simulations; Other
Lead sponsor: Qure Healthcare, LLC; Industry
Eligibility: Not listed
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Alcohol Abuse, Alcohol Abuse/addiction, Anxiety, Pain Threshold, Depression Disorders, Sleep Disorder
Interventions: AFA-281; Drug
Lead sponsor: Afasci Inc; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cannabinoid Hyperemesis Syndrome
Interventions: Haloperidol; Drug
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Bipolar Disorder
Interventions: Lithium, Divalproex, Placebo; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 16 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2006
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Opioid Use Disorder
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Depression, Alcoholism, Drug Abuse
Interventions: Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR), Psycho-education & Understanding Bipolar Medications Therapy; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Alcohol Abuse
Interventions: Strengths Based Case Management, Motivational Enhancement Therapy, Brief Informational Feedback; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 19 Years to 60 Years
Enrollment: 686 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Cannabis Dependence, Marijuana Dependence
Interventions: Dronabinol, Clonidine, Placebo; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Opioid-use Disorder, Substance Use Disorders
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: InSightec; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 4
States / cities: Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more

Conditions: Bipolar Disorder, Alcohol Abuse/Dependence
Interventions: Quetiapine; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2004
U.S. locations: 1
States / cities: Dallas, Texas

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A Study of Loco-Regional Liposomal Bupivacaine Injection

Methamphetamine Abuse Treatment in Patients With AIDS - 1

Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Enhanced Motivational Interviewing With Alcohol Positive Trauma Patients

Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care

Antioxidant Replacement Therapy in Patients With Alcohol Abuse

Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder

Health Behavior Feedback Study for Veterans With Hepatitis C

Can The Bridge Transition Opiate Use Disorder Patients in Stable Recovery From Buprenorphine to Naltrexone

Pregnenolone Trial for Depression in Bipolar Disorders or Recurrent Major Depressive Disorder With Substance Abuse

Substance Use Prevention in Teen Psychiatric Patients

Trial of Adherence App for Buprenorphine Treatment (TAAB) Study

Assessing Opioid Care Practices Using CPV Patient Simulation Modules

A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder

Haloperidol For Outpatient Symptom Management in Patients Diagnosed With Cannabinoid Hyperemesis Syndrome in the Emergrency Department

Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Project Health Link: Connecting Patients With Services

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence