- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Interventions
- Epi-ON corneal cross-linking (CXL)
- Combination Product
- Lead sponsor
- Woolfson Eye Institute
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 225 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 12
- States / cities
- Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more
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Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.
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Showing 1–15
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matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration, Forme Fruste Keratoconus (FFK)
- Interventions
- Epi-ON corneal cross-linking
- Combination Product
- Lead sponsor
- Woolfson Eye Institute
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 485 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 12
- States / cities
- Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more
- Conditions
- Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia
- Interventions
- Brillouin Ocular Scanner
- Device
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 15 Years to 75 Years
- Enrollment
- 85 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2020
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Corneal Ectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Colorado Eye Consultants/Cornea Consultants of Colorado
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2023
- U.S. locations
- 3
- States / cities
- Littleton, Colorado • Highland Park, Illinois • Brecksville, Ohio
- Conditions
- Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia, Corneal Trauma, Corneal Scar, Dry Eye Syndromes, Keratoconjunctivitis Sicca, Sjogren's Syndrome
- Interventions
- Ocular surface optical coherence tomography
- Device
- Lead sponsor
- Boston Sight
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 11 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Needham, Massachusetts
- Conditions
- Keratoconus, Ectasia, Degeneration
- Interventions
- Ciprofloxicine or Vigamox or other., Nonsteroidal (Acular, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Drug
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 1,189 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2017
- U.S. locations
- 3
- States / cities
- Miami, Florida • Rockville, Maryland • Fairfax, Virginia
- Conditions
- Corneal Diseases
- Interventions
- Not listed
- Lead sponsor
- Carl Zeiss Meditec, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 769 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2007 – 2008
- U.S. locations
- 4
- States / cities
- La Jolla, California • San Diego, California • Greenwood Village, Colorado + 1 more
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Cornea Associates of Texas
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 249 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2024
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents
- Interventions
- CXLO Corneal Strengthening Solution and UVA Illumination Device
- Combination Product
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 2,228 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2020
- U.S. locations
- 9
- States / cities
- Scottsdale, Arizona • San Francisco, California • Littleton, Colorado + 6 more
- Conditions
- Keratoconus
- Interventions
- Theralight crosslinking and Riboflavin
- Other
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 1,324 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2017
- U.S. locations
- 6
- States / cities
- Miami, Florida • Atlanta, Georgia • Rockville, Maryland + 3 more
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Goodman Eye Center
- Other
- Eligibility
- 10 Years and older
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2029
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Keratoconus, Ectasia
- Interventions
- Riboflavin Solution, UV-X Illumination System
- Other · Device
- Lead sponsor
- Stephen Trokel
- Other
- Eligibility
- 16 Years and older
- Healthy volunteers
- Accepts healthy volunteers
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Cornea Associates of Texas
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Keratoconus, Ectasia, Degeneration
- Interventions
- Not listed
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 2,619 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2017
- U.S. locations
- 5
- States / cities
- San Diego, California • Littleton, Colorado • Hoffman Estates, Illinois + 2 more
- Conditions
- Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront, Wavefront Aberration, Corneal, Pellucid Marginal Corneal Degeneration, Keratoglobus
- Interventions
- Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
- Device
- Lead sponsor
- Cornea and Laser Eye Institute
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2025
- U.S. locations
- 1
- States / cities
- Teaneck, New Jersey