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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: People Who Inject Drugs Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Adaptation and Implementation of Project Encuentro in the U.S.-Mexico Border

NCT03293875
View directory record Official record
Conditions
HIV
Interventions
Community Events, Social Network HIV Testing, Peer Network Intervention
Behavioral
Lead sponsor
City University of New York
Other
Eligibility
18 Years and older
Enrollment
840 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Setting Focus Overdose Prevention Intervention

NCT05320835
View directory record Official record
Conditions
HIV Infections, HCV, Drug Overdose
Interventions
HIV, HCV and overdose prevention
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
285 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Tele-Harm Reduction

NCT05208697
View directory record Official record
Conditions
IV Drug Usage, HIV Infections, Hepatitis C
Interventions
Tele-Harm Reduction, off-site linkage
Behavioral · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Fort Lauderdale, Florida • Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

Integrated PrEP Interventions for People Who Inject Drugs in Rural Kentucky

NCT05037513
View directory record Official record
Conditions
HIV Prevention
Interventions
SBCM-PrEP, CDC-PrEP
Behavioral
Lead sponsor
Hilary L Surratt, PhD
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Recruiting Not applicable Interventional

PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

NCT05769218
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
CHORUS+, Standard of care
Behavioral · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

EPIC-P Intervention

NCT04193787
View directory record Official record
Conditions
HIV
Interventions
EPIC-P
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

MAPS PrEP Van Study

NCT06908252
View directory record Official record
Conditions
HIV Infection
Interventions
Pre-Exposure Prophylaxis (PrEP)
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 4 Interventional Results available

Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of Care

NCT03093415
View directory record Official record
Conditions
Hepatitis C, Substance Use Disorders, Substance Abuse, Intravenous
Interventions
elbasvir-grazoprevir (50 mg/100 mg)
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit

NCT04804072
View directory record Official record
Conditions
HIV Infections, Drug Use, Opioid Use, Opioid-use Disorder
Interventions
Medication for opioid-use disorder (MOUD) for opioid-use disorder (OUD), HIV testing, HIV treatment for participants living with HIV not already in care, PrEP for participants without HIV, Testing and referral for vaccination or treatment for hepatitis A virus (HAV) and hepatitis B virus (HBV), Testing and referral for treatment for hepatitis C virus (HCV), Sexually transmitted infection (STI) testing and treatment, Primary care, Harm reduction services, Peer navigation, COVID-19 testing and referral for further evaluation, care and/or treatment
Drug · Diagnostic Test · Other + 1 more
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
18 Years and older
Enrollment
447 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
5
States / cities
Los Angeles, California • Washington D.C., District of Columbia • The Bronx, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Recruiting Phase 4 Interventional

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

NCT05669534
View directory record Official record
Conditions
Hiv, Opioid Use Disorder
Interventions
community-friendly health recovery program, Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis
Behavioral · Drug
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eliminating HCV in Rural South Carolina Utilizing NP Led Mobile Clinics and Virtual Care Coordination

NCT05369507
View directory record Official record
Conditions
Hepatitis C, Substance Use Disorders
Interventions
Virtual Care Coordination
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Increasing HCV Linkage to Care Among People Who Inject Drugs

NCT04741750
View directory record Official record
Conditions
Hepatitis C
Interventions
Simplified HCV care within a mobile medical unit
Other
Lead sponsor
Family Health Centers of San Diego
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Sep 27, 2026, 4:23 AM EDT
Not listed Not applicable Interventional

The Staying Safe Intervention

NCT03418636
View directory record Official record
Conditions
Hepatitis C, Opioid Use
Interventions
Staying Safe (Ssafe), Healthy Living
Behavioral
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
18 Years to 29 Years
Enrollment
456 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 3 Interventional Results available

Randomised Study of Interferon-free Treatment for Recently Acquired Hepatitis C in PWID and People With HIV Coinfection.

NCT02625909
View directory record Official record
Conditions
Hepatitis C
Interventions
SOF/VEL for 6 weeks, SOF/VEL for 12 weeks
Drug
Lead sponsor
Kirby Institute
Government
Eligibility
18 Years and older
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs

NCT06733506
View directory record Official record
Conditions
Opioid Use Disorder, Injection Drug Use, Skin and Soft Tissue Infections (SSTIs)
Interventions
Chlorhexidine gluconate, Isopropyl Alcohol 70% Topical Application Solution, Skin Prep Before Injecting Recreational/Street Drugs
Drug · Behavioral
Lead sponsor
Gabriel John Culbert
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

BRIDGE: Improving HIV Service Delivery for People Who Inject Drugs

NCT02796027
View directory record Official record
Conditions
Human Immunodeficiency Virus, Substance Abuse, Intravenous
Interventions
BRIDGE
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
616 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2022 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Testing of the Integrated Rapid Access to HIV Prevention Program for People Who Inject Drugs Program

NCT04531670
View directory record Official record
Conditions
HIV Prevention Program, Opioid-use Disorder
Interventions
iRaPID, Standard of Care
Behavioral · Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 27, 2026, 4:23 AM EDT
Completed No phase listed Observational Results available

Hepatitis C Pharmacy-based Strategy for Injectors

NCT04698629
View directory record Official record
Conditions
Hepatitis C
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Integrated HIV Prevention and HCV Care for PWID

NCT03981445
View directory record Official record
Conditions
HIV Prevention, HCV, Opioid Use, Intravenous Drug Usage
Interventions
ARTAS Adapted Patient Navigation, Adherence Counseling
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 64 Years
Enrollment
446 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advancing Access to HIV/HCV Testing for People Who Inject Drugs (PWID)

NCT06730555
View directory record Official record
Conditions
HIV Infections
Interventions
ACCESS Intervention, Control Group
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Not listed Not applicable Interventional

Implementing HCV Treatment for High-risk Populations in Austin, Texas

NCT05460130
View directory record Official record
Conditions
Hepatitis C Virus Infection
Interventions
Simplified Hepatitis C Virus (HCV) Treatment Protocol
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Intervention to Improve HIV Self-care Among People Who Inject Drugs

NCT05819411
View directory record Official record
Conditions
Hiv, Substance Use Disorders
Interventions
Project iSTRIVE, incentivized Directly Observed Therapy (iDOT)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Not listed Phase 4 Interventional

Treatment of HCV-Infected Recent Injection Drug Users in U.S. Liver Clinics

NCT05895448
View directory record Official record
Conditions
Chronic Hepatitis C, People Who Inject Drugs
Interventions
velpatasvir and sofosbuvir once daily for 12 weeks (brand or branded generic) .
Drug
Lead sponsor
Center For Hepatitis C, Atlanta, GA
Other
Eligibility
18 Years to 75 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

Patient-Centered Models of HCV Care for People Who Inject Drugs

NCT02824640
View directory record Official record
Conditions
Hepatitis C, Medication Adherence
Interventions
Patient Navigation, modified Directly Observed Therapy
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years to 70 Years
Enrollment
755 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Sep 27, 2026, 4:23 AM EDT