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Showing 25–45 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Performance Enhancement Clear all
Completed Not applicable Interventional

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine

NCT03928041
View directory record Official record
Conditions
Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
Interventions
Device: EVOS Lumbar Interbody System (EVOS-HA)
Device
Lead sponsor
Invibio Ltd
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults

NCT03512028
View directory record Official record
Conditions
Healthy, Young Adults
Interventions
RLIC, Sham conditioning, Muscle strength training, Driving training, Balance training
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 40 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Photomedicine Project 14: PBMT for Performance Enhancement in SOF

NCT06380179
View directory record Official record
Conditions
Photobiomodulation Therapy, Photomedicine, Low-Level Laser Therapy, Performance Enhancement, Quadriceps, Special Operations Readiness
Interventions
THOR3 training + Photobiomodulation Therapy (PBMT), THOR3 training + sham PBMT
Device
Lead sponsor
Musculoskeletal Injury Rehabilitation Research for Operational Readiness
Federal
Eligibility
18 Years to 45 Years · Male only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Joint Base Lewis McChord, Washington
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 4, 2026, 11:33 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Brain-Physical Optimization Conditioning

NCT04863469
View directory record Official record
Conditions
Physical Performance
Interventions
B-POC high load intervention, B-POC low load intervention
Behavioral
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 40 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindful Mental Training for Surgeons to Enhance Resilience and Performance Under Stress

NCT03141190
View directory record Official record
Conditions
Burnout Syndrome, Surgery, Stress
Interventions
Mindfulness Based Stress Reduction - modified, Active listening and reading
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional

PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study

NCT01168128
View directory record Official record
Conditions
Critically Ill, Intensive Care Unit
Interventions
Tailored Change Strategy
Other
Lead sponsor
Daren K. Heyland
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Annapolis, Maryland • Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Non-Invasive Brain Stimulation on Soldiers' Cognitive and Functional Performance

NCT04155333
View directory record Official record
Conditions
Performance Enhancement
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
United States Army Aeromedical Research Laboratory
Federal
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Rucker, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effect of Huperzine A on Cognitive Function and Perception of Effort During Exercise

NCT03445104
View directory record Official record
Conditions
Cognitive Enhancement During Exercise
Interventions
Huperzine A, Placebo
Other
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 30, 2018 · Synced Sep 4, 2026, 11:33 PM EDT
Completed No phase listed Observational

Role of Brain Region Changes in Tactile (Touch) Ability Following Nerve Block

NCT00357058
View directory record Official record
Conditions
Tactile Spatial Acuity, Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhanced Stress Resilience Training for Residents

NCT03518359
View directory record Official record
Conditions
Stress, Mindfulness, Cognitive Change
Interventions
Enhanced Stress Resilience Training (ESRT), Active Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2022 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional

Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

NCT01633138
View directory record Official record
Conditions
Substance-Related Disorders, Mental Disorders
Interventions
Cognitive Remediation Therapy - Standard, Cognitive Remediation Therapy plus Contingency Management
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional

Automated Diabetes Registry Tools to Enhance Patient Self-Management and Provider Performance Feedback

NCT00827710
View directory record Official record
Conditions
Diabetes
Interventions
point of care patient report cards, Provider performance report card
Behavioral
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 75 Years
Enrollment
5,457 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 30, 2012 · Synced Sep 4, 2026, 11:33 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Acute and Mild TBI Injury in Military and Civilian Population Using Advanced MR Imaging

NCT05101239
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
MRI imaging exam
Device
Lead sponsor
The Geneva Foundation
Other
Eligibility
18 Years to 55 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Conditionally Increased Output (CIO) Enhanced Ultrasound System

NCT05792423
View directory record Official record
Conditions
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Fatty Liver
Interventions
GE ultrasound system with increased acoustic output settings
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Sep 4, 2026, 11:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Performance and Accuracy of an AI Enhanced Smart Watch Single Lead ECG

NCT05450809
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhanced vs. Routine Clear Liquid Intake in Labor

NCT02524002
View directory record Official record
Conditions
Abnormal Labor, Failed Induction of Labor, Ketosis
Interventions
Accel Gel, Usual clear diet
Dietary Supplement
Lead sponsor
Temple University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ACtive Children Enhance LEaRning and AttenTION: A Randomized Controlled Trial (RCT)

NCT05794360
View directory record Official record
Conditions
Physical Inactivity
Interventions
ACtive Children Enhance LEaRning and AttenTION (ACCELERATION)
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
8 Years to 11 Years
Enrollment
257 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Sep 4, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality and tACS for Performance Enhancement

NCT03636126
View directory record Official record
Conditions
Law Enforcement Officers
Interventions
VR + TACS
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Garland, Texas
Source: ClinicalTrials.gov public record
Updated Jul 25, 2021 · Synced Sep 4, 2026, 11:33 PM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

tFUS to Enhance Alertness and Performance

NCT06461221
View directory record Official record
Conditions
Reaction Time, Alertness
Interventions
Transcranial Focused Ultrasound
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
22 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 4, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acoustic Stimulation During Restricted Sleep After Sleep Deprivation

NCT05309473
View directory record Official record
Conditions
Sleep Deprivation, Sleep Restriction, Acoustic Stimulation, Performance, Alertness
Interventions
Philips SmartSleep Acoustic Stimulation Device, Sham (no Acoustic Stimulation)
Device
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 39 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Sep 4, 2026, 11:33 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance

NCT05852730
View directory record Official record
Conditions
Motion Sickness, Space, Motion Simulation, Parabolic Flight
Interventions
DPI-386 Nasal Gel, Other (e.g., promethazine, meclizine)
Drug
Lead sponsor
Repurposed Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 4, 2026, 11:33 PM EDT