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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Periodontal Inflammation Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Instructed Dental Flossing on Interdental Gingival Bleeding: A Randomized Controlled Clinical Trial

NCT04218994
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Flossing technique
Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Sep 4, 2026, 2:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Risk for Infective Endocarditis

NCT05721781
View directory record Official record
Conditions
Bacteremia, Infective Endocarditis
Interventions
Oral Hygiene instruction, Dental Cleaning
Behavioral · Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
6
States / cities
Boston, Massachusetts • Ann Arbor, Michigan • Newark, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model

NCT00779909
View directory record Official record
Conditions
Gingivitis
Interventions
vitamin D3, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 64 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2017 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlation Between Oral Health and Systemic Inflammation (COHESION)

NCT03641989
View directory record Official record
Conditions
Inflammation, Periodontal Disease, Gingivitis
Interventions
Plaque disclosing toothpaste, Non-plaque disclosing toothpaste
Other
Lead sponsor
Marshfield Clinic Research Foundation
Other
Eligibility
21 Years to 84 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Marshfield, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Next Science Antimicrobial Mouth Rinse Study

NCT03154021
View directory record Official record
Conditions
Gingivitis, Dental Plaque
Interventions
Next Science OTC Oral Rinse with Essential Oils, OTC Oral Rinse Control
Combination Product
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

NCT02187185
View directory record Official record
Conditions
Inflammation, Periodontitis
Interventions
Sonicare/Elite-Flexcare Toothbrush, Manual Toothbrush
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

NCT03762915
View directory record Official record
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
minocycline HCl microspheres
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 4, 2026, 2:51 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization

NCT05932017
View directory record Official record
Conditions
Periodontal Diseases, Periodontal Pocket, Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss, Periodontal Bone Loss, Surgery
Interventions
Not listed
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Not applicable Interventional

Randomized Trial of a Gum Health Formulation

NCT03196648
View directory record Official record
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis

NCT02342691
View directory record Official record
Conditions
Gingival Inflammation
Interventions
BLXA4, Placebo oral rinse
Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2023 · Synced Sep 4, 2026, 2:51 AM EDT
Recruiting Not applicable Interventional

Peri-implantitis Management: Surgical and Maintenance Outcomes

NCT07550127
View directory record Official record
Conditions
Peri-implantitis
Interventions
Resective surgery with implantoplasty, Resective surgery with mechanical debridement
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 4, 2026, 2:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Third Molar Clinical Trials: Pericoronitis Studies

NCT01882270
View directory record Official record
Conditions
Pericoronitis
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2014 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Toothbrush Wear and Its Effect on Subgingival Inflammation Using Two Different Brushing Techniques

NCT03158350
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Instructed Brushing Method
Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2019 · Synced Sep 4, 2026, 2:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Epigenetics, DNA Methylation Patterns and Periodontal Disease

NCT01399034
View directory record Official record
Conditions
Periodontal Disease
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2011 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Phase 4 Interventional Results available

Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation

NCT04187053
View directory record Official record
Conditions
DENT IMPLANTS, LASER
Interventions
Conventional mechanical therapy, Saline, Methylene Blue, Light emitting laser, Non-light emitting laser
Procedure · Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Sep 4, 2026, 2:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis

NCT02794012
View directory record Official record
Conditions
Rheumatoid Arthritis, Periodontal Disease
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 99 Years
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Sep 4, 2026, 2:51 AM EDT
Active, not recruiting Phase 2 Interventional

Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant

NCT05579639
View directory record Official record
Conditions
Allogeneic Stem Cell Transplantation
Interventions
Xylitol, Placebo
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
4 Months to 25 Years
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Aurora, Colorado • Boston, Massachusetts • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 4, 2026, 2:51 AM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Topical 10% Povidone-Iodine in Preventing White Spots

NCT06616207
View directory record Official record
Conditions
White Spot Lesions, Gingival Inflammation and Bleeding
Interventions
Placebo, Povidone-iodine solution
Drug
Lead sponsor
University of Washington
Other
Eligibility
10 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 4, 2026, 2:51 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Association of Periodontal Inflammation on Immune Response in Wound Healing

NCT04805320
View directory record Official record
Conditions
Inflammation of Mouth
Interventions
Dental Extraction
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
21 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Phase 4 Interventional Results available

Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients

NCT01647282
View directory record Official record
Conditions
Moderate to Advanced Chronic Periodontitis
Interventions
locally-applied minocycline HCl (1 mg), scaling and root planing (Sc/RP)
Drug · Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 24, 2023 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Not applicable Interventional

Effect of Smartphone Application on Reducing Localized Inflammation in Periodontal Maintenance Patients

NCT04546295
View directory record Official record
Conditions
Periodontal Inflammation
Interventions
Brushlink application, Water-flosser, Interproximal brush
Other
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 85 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 4, 2026, 2:51 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Rapid Point-of-Care Salivary Diagnostic for Periodontal Health

NCT02403297
View directory record Official record
Conditions
Gingivitis, Periodontal Disease
Interventions
Quik Check PD
Device
Lead sponsor
Innovative Diagnostics Inc
Industry
Eligibility
18 Years to 95 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Sep 4, 2026, 2:51 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluate Inflammation Caused by Gingivitis in Adults

NCT00941668
View directory record Official record
Conditions
Gingivitis
Interventions
Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Sep 4, 2026, 2:51 AM EDT
Recruiting No phase listed Observational

Inflammation in Clear Aligners With and Without Attachments

NCT07506993
View directory record Official record
Conditions
Periodontal Inflammation
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
14 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 4, 2026, 2:51 AM EDT