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Showing 25–47 of 23 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Gingivitis
Interventions
Iocide Oral Rinse, Placebo
Drug
Lead sponsor
Biomedical Development Corporation
Industry
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
San Antonio, Texas
Conditions
Moderate to Advanced Chronic Periodontitis
Interventions
locally-applied minocycline HCl (1 mg), scaling and root planing (Sc/RP)
Drug · Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Periodontal Inflammation and Epigenetics in Obese Individuals

NCT07610902
Conditions
Obesity, Periodontitis
Interventions
Non-surgical periodontal therapy will be administered
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Conditions
Diabetes, Insulin Resistance, Inflammation, Cardiovascular Disease, Periodontal Disease
Interventions
2 groups of population responding to 2 types of diets
Behavioral
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
25 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Toothbrush Bristles

NCT07306026
Conditions
Gingivitis and Periodontal Diseases
Interventions
Toothbrush with tapered bristles, Toothbrush with end-rounded bristles
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Topical 10% Povidone-Iodine in Preventing White Spots

NCT06616207
Conditions
White Spot Lesions, Gingival Inflammation and Bleeding
Interventions
Placebo, Povidone-iodine solution
Drug
Lead sponsor
University of Washington
Other
Eligibility
10 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

NCT07095556
Conditions
Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management, Tooth Extraction Site Healing
Interventions
Low-level laser therapy
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Gingival Inflammation
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Loma Linda, California
Conditions
Gingival Inflammation, Dental Caries
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Loma Linda, California
Conditions
Wound Heal, Mouth; Wound, Periodontal Inflammation
Interventions
Emanate Tray
Device
Lead sponsor
Emanate Biomedical Inc.
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Cambridge, Massachusetts
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

NCT03762915
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
minocycline HCl microspheres
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Risk for Infective Endocarditis

NCT05721781
Conditions
Bacteremia, Infective Endocarditis
Interventions
Oral Hygiene instruction, Dental Cleaning
Behavioral · Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
6
States / cities
Boston, Massachusetts • Ann Arbor, Michigan • Newark, New Jersey + 3 more
Completed Not applicable Interventional Accepts healthy volunteers

Correlation Between Oral Health and Systemic Inflammation (COHESION)

NCT03641989
Conditions
Inflammation, Periodontal Disease, Gingivitis
Interventions
Plaque disclosing toothpaste, Non-plaque disclosing toothpaste
Other
Lead sponsor
Marshfield Clinic Research Foundation
Other
Eligibility
21 Years to 84 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Marshfield, Wisconsin
Conditions
Gingivitis, Investigation of Biological Markers of Inflammation
Interventions
Iocide Oral Rinse, Placebo
Drug
Lead sponsor
Biomedical Development Corporation
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Lexington, Kentucky
Conditions
HIV, Periodontal Diseases, Caries, Non-communicable Disease, Xerostomia
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
227 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Recruiting No phase listed Observational Accepts healthy volunteers

Association of Periodontal Inflammation on Immune Response in Wound Healing

NCT04805320
Conditions
Inflammation of Mouth
Interventions
Dental Extraction
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
21 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lincoln, Nebraska
Completed No phase listed Observational Accepts healthy volunteers

Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis

NCT02794012
Conditions
Rheumatoid Arthritis, Periodontal Disease
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 99 Years
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Recruiting Not applicable Interventional

Oil Pulling Reduction

NCT07706647
Conditions
Good Health, Gingival Inflammation and Bleeding, Dental Plaque
Interventions
GuruNanda natural Oil Pulling oral rinse, TheraBreath Plaque Control Oral Rinse, GuruNanda water-based non-whitening mouthwash
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Conditions
Inflammation, Periodontitis
Interventions
Sonicare/Elite-Flexcare Toothbrush, Manual Toothbrush
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Completed No phase listed Observational Accepts healthy volunteers

Periodontal and Periapical Inflammation and Pregnancy

NCT00490165
Conditions
Periodontal Disease, Periapical Disease, Pregnancy, Diabetes, Cardiovascular Disease, Dental Caries
Interventions
Not listed
Lead sponsor
Roger Johnson
Other
Eligibility
10 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Jackson, Mississippi
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluate Inflammation Caused by Gingivitis in Adults

NCT00941668
Conditions
Gingivitis
Interventions
Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Periodontal Diseases, Periodontal Pocket, Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss, Periodontal Bone Loss, Surgery
Interventions
Not listed
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas