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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Periodontal Surgery Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
View directory record Official record
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment, Endodontic Lesions, PeriodontalConditions, Oral Surgery Conditions, Tooth Extractions, Local Anesthesia, Traumatic Dental Pain, TMJ, Orthodontics, Endodontic Histopathology, Periodontal Diseases
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis

NCT03127228
View directory record Official record
Conditions
Peri-Implantitis
Interventions
Standard mechanical debridement, Er:YAG laser-assisted debridement
Other · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 14, 2019 · Synced Sep 24, 2026, 1:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Microsurgery and Periodontal Healing

NCT07054008
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Microsurgical approach with Digital Microscope
Procedure
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 18 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 24, 2026, 1:23 PM EDT
Completed No phase listed Observational

Patient-Reported Probiotic Use During Periodontal Therapy in Periodontitis

NCT07619040
View directory record Official record
Conditions
Periodontitis, Probiotic, Oral Hygiene, Oral Health, Periodontal Therapy
Interventions
non surgical periodontal therapy
Procedure
Lead sponsor
Medipol University
Other
Eligibility
18 Years to 70 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Recruiting Not applicable Interventional

Peri-implantitis Management: Surgical and Maintenance Outcomes

NCT07550127
View directory record Official record
Conditions
Peri-implantitis
Interventions
Resective surgery with implantoplasty, Resective surgery with mechanical debridement
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery

NCT04957342
View directory record Official record
Conditions
Pain, Postoperative, Gingival Diseases
Interventions
amnion-chorion membrane, Sutures
Device · Procedure
Lead sponsor
Harvard Medical School (HMS and HSDM)
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Application of L-PRF in Periodontal Surgery

NCT06296498
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Leukocyte Platelet-rich fibrin, Standard of care OFD
Procedure · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets

NCT02316652
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Scaling and root planing, Scaling and root planing with solution
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 24, 2026, 1:23 PM EDT
Completed No phase listed Observational

Systemic Markers of Inflammation: 9- and 12-Month Follow-Up Post Non-Surgical Periodontal Therapy

NCT04312542
View directory record Official record
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
Measurement of Biomarkers
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness

NCT02450383
View directory record Official record
Conditions
Tooth Loss, Peri-implant Mucosa Defect
Interventions
Acellular Dermal Matrix, Autologous subepithelial connective tissue graft
Drug · Procedure
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative

NCT05565079
View directory record Official record
Conditions
Recession, Gingival
Interventions
Regenerative tissue matrix and enamel matrix derivative, Regenerative tissue matrix
Biological
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed No phase listed Observational

Microbes and Bariatric Surgery

NCT01130207
View directory record Official record
Conditions
Obesity, Diabetes, Periodontal Disease
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Pinhole Surgical Technique Compared to Connective Tissue Graft in Treatment of Gingival Recession

NCT04356391
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Connective Tissue Graft Technique, Pinhole Surgical Technique
Procedure
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
19 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Sep 24, 2026, 1:23 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Laser Therapy Treatment of Peri-implantitis.

NCT01972399
View directory record Official record
Conditions
Peri-implantitis
Interventions
Laser, Mechanical debridement
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 2, 2015 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Phase 1Phase 2 Interventional

The Anesthetic and Analgesic Effect of Adjunct Liposomal Bupivacaine in Periodontal Surgical Procedures

NCT07725731
View directory record Official record
Conditions
Periodontal Surgery
Interventions
0.5% Bupivacaine HCl, Liposomal Bupivacaine (EXPAREL®)/Bupivacaine
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.

NCT07637838
View directory record Official record
Conditions
Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain, Analgesic Consumption
Interventions
Platelet rich fibrin, Control Group: collagen matrices or oxidized cellulose membrane
Procedure · Other
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 99 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional Results available

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

NCT05252000
View directory record Official record
Conditions
Periodontal Diseases
Interventions
mechanical debridement, adjunctive aPDT, sham aPDT
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Pilot Study to Evaluate the Use of OroScience Topical Oral Wound Emulsion in Post Operative Wound Healing

NCT00596141
View directory record Official record
Conditions
Oral Surgical Procedures, Pain
Interventions
OroScience Topical Oral Wound Emulsion
Device
Lead sponsor
OroScience, Inc.
Industry
Eligibility
21 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated May 7, 2013 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

PRF + Minocycline vs Arestin in Non-surgical Perio Therapy

NCT07437209
View directory record Official record
Conditions
Non-surgical Periodontal Therapy
Interventions
Arestin, PRF + M
Drug · Biological
Lead sponsor
Center for Advanced Rejuvenation and Esthetics
Network
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Diode Laser Study for Periodontal Maintenance Patients

NCT01215201
View directory record Official record
Conditions
Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative, Suppuration of Gingival Crevice
Interventions
Scaling and Root Planing, Diode Laser + Scaling and Root Planing
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Sep 24, 2026, 1:23 PM EDT
Terminated No phase listed Observational

Clinical Outcomes of Resective Surgical Treatment of Peri-Implantitis With or Without Implantoplasty

NCT04259840
View directory record Official record
Conditions
Peri-Implantitis
Interventions
Observation
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
41 participants
Timeline
2019 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 10, 2021 · Synced Sep 24, 2026, 1:23 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy

NCT00755911
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Tissue Repair Cells (TRC), Control
Biological · Device
Lead sponsor
University of Michigan
Other
Eligibility
20 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 2, 2015 · Synced Sep 24, 2026, 1:23 PM EDT
Terminated No phase listed Interventional Results available

Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® Emdogain

NCT01614925
View directory record Official record
Conditions
Periodontal Attachment Loss, Periodontal Diseases
Interventions
Emdogain, Periodontal surgery
Device · Procedure
Lead sponsor
Institut Straumann AG
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Sep 24, 2026, 1:23 PM EDT