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ClinicalTrials.gov public records Last synced Nov 14, 2026, 11:53 PM EST

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Showing 1–24 of 71 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Perioperative Analgesia Clear all

Conditions: Pain
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 10 Years to 18 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Abdominal Hysterectomy (& Wertheim)
Interventions: Lidocaine, Placebo, Ketamine, Ketamine + Lidocaine; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Mayfield Heights, Ohio

Conditions: Cesarean Section Complications, Opioid Use
Interventions: Preoperative Genotyping; Diagnostic Test
Lead sponsor: Senthil Sadhasivam; Other
Eligibility: 18 Years and older · Female only
Enrollment: 700 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 4
States / cities: Indianapolis, Indiana • St Louis, Missouri • Pittsburgh, Pennsylvania

Conditions: Post-operative Pain
Interventions: Multimodal Pain Management (Ibuprofen/Acetaminophen/GABAPentin/0.25%Bupivacaine); Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: San Diego, California

Conditions: Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
Interventions: Bupivicaine intervention arm, Placebo arm; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Elective Spine Surgery Receiving Pre and/or Postoperative Pain Control With Opioids
Interventions: Opioid and Benzodiazepine Naive-patients, Opioid and Benzodiazepine Tolerant-patients; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 21 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pain, Postoperative, Opioid Use Disorder
Interventions: Patient Engagement Tools, Educational Guide; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: THA
Interventions: Duloxetine, Placebo; Drug · Other
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Degenerative Joint Disease of Shoulder
Interventions: Cryoneurolysis, No cryoneurolysis; Device · Other
Lead sponsor: North Texas Medical Research Institute, PLLC; Other
Eligibility: 30 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Rockwall, Texas

Conditions: Post-operative Pain, Post-operative Nausea and Vomiting, Respiratory Depression, Confusion Postoperative
Interventions: ComfortSafe Care; Procedure
Lead sponsor: Georgetown University; Other
Eligibility: 21 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Tonsillitis
Interventions: Fentanyl, Dexmedetomidine; Drug
Lead sponsor: Children's National Research Institute; Other
Eligibility: 2 Years to 12 Years
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: PPAP, Spine Fusion
Interventions: Preoperative Genotyping; Diagnostic Test
Lead sponsor: Senthil Sadhasivam; Other
Eligibility: 10 Years to 21 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 5
States / cities: San Francisco, California • St. Petersburg, Florida • Indianapolis, Indiana + 1 more

Conditions: Post Operative Analgesia, Bariatric Surgery, Bariatric Surgery (Gastric Bypass), Bariatric Surgery Patients, Perioperative Analgesia
Interventions: Acetaminophen; Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Colorectal Surgery
Interventions: Placebo, Ketamine high-dose, Ketamine low-dose; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Foot and Ankle Procedures
Interventions: Dexamethasone, Saline; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Liver Disease, Pain
Interventions: paravertebral blocks; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Colon Cancer, Colon Diverticulosis, Colonic Neoplasms, Colonic Diverticulitis, Pain, Postoperative, Ileus, Ileus Paralytic, Ileus; Mechanical, Constipation Drug Induced, Constipation, Rectum Cancer, Rectum Neoplasm
Interventions: Acetaminophen, Gabapentin, Orphenadrine, Lidocaine, Marcaine, Ketamine, Methadone, Tramadol, Ketorolac, Morphine Sulfate, Fentanyl, Dilaudid, Hydrocodone-Acetaminophen Tab 5-325 MG, HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET; Drug
Lead sponsor: University of Illinois College of Medicine at Peoria; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Peoria, Illinois

Conditions: Oncologic Surgery, Cancer, Cancer Surgery, Hepatic Cancer, Gastric (Cardia, Body) Cancer, Biliary Tract Cancer, Pancreatic Cancer Resectable, Gynecologic Cancers, Gastrointestinal Cancers, Colorectal Cancer, Minimally Invasive Surgical Procedures
Interventions: Local Anesthesia, Laparoscopic Transversus Abdominis Plane block; Procedure
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 18 Years to 89 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Postoperative Pain
Interventions: Methadone, Saline; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Multimodal Analgesic Approach
Interventions: Ofirmev, Per Os Acetaminophen; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 85 Years
Enrollment: 166 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Spine Surgery, Pain After Surgery, Anesthesia , Analgesia
Interventions: NOL guided intraoperative analgesia; Device
Lead sponsor: Medasense Biometrics Ltd; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pain, Postoperative
Interventions: Epidural Analgesia, Parenteral Analgesia (Intravenous); Procedure
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Orange, California

Conditions: Pectus Excavatum, Pain, Postoperative
Interventions: Ultrasound-guided Sub-Paraspinal Block, PCA only; Procedure
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 12 Years to 17 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions: Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline; Drug
Lead sponsor: John O'Toole; Other
Eligibility: 18 Years to 80 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Pharmacogenetic Morphine Spine Study

Lidocaine and Ketamine in Abdominal Surgery

Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Comparing Perioperative Outcomes in Pain Control

COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block

Impact of Daily, Digital and Behavioral Tele-health Tapering Program for Perioperative Surgical Patients Exposed to Opioids and Benzodiazepines.

Patient Engagement in Perioperative Pain Management Project

Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA)

Multimodal Perioperative Pain Management: ComfortSafe Program

Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy

Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)

Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients

Effect of Ketamine on Postoperative Clinical Outcomes

Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery

Comparison Between Epidural and Bilateral Paravertebral Blocks in Liver Resection

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery

Methadone Versus Placebo in Spine Fusion

IV vs Oral Acetaminophen in Spine Fusion Perioperative Care

Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot

Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.

Sub-Paraspinal Block in Nuss Patients. A Pilot Project

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery