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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Peripheral Diabetic Neuropathy Clear all
Completed Phase 2 Interventional Results available

The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy

NCT02643251
View directory record Official record
Conditions
Painful Diabetic Neuropathy, Diabetic Neuropathy, Neuropathy
Interventions
Clonidine Hydrochloride Topical Gel, 0.1%, Clonidine Hydrochloride Gel Comparator
Drug
Lead sponsor
BioDelivery Sciences International
Industry
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
25
States / cities
Glendale, Arizona • Phoenix, Arizona • Anaheim, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2017 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 2 Interventional

A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain

NCT01345045
View directory record Official record
Conditions
Diabetic Neuropathic Pain
Interventions
ABT-639, pregabalin, Placebo
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
18 Years to 75 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
19
States / cities
Little Rock, Arkansas • Anaheim, California • Long Beach, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2013 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 4 Interventional

A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions

NCT00904202
View directory record Official record
Conditions
Postherpetic Neuralgia, Diabetic Neuropathy, Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, HIV Neuropathy, Idiopathic Sensory Neuropathy, Peripheral Neuropathy
Interventions
Placebo Capsules + Placebo Patch, Placebo capsules + Lidoderm®, Gabapentin + Placebo, Gabapentin + Lidoderm®, Gabapentin 300 mg capsules 1800 mg/day + placebo patch, Gabapentin 1800 mg/day + Lidoderm patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
7
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Jul 23, 2026, 7:06 AM EDT
Withdrawn Not applicable Interventional

Oral Thiamine for the Treatment of Painful Diabetic Peripheral Neuropathy

NCT00279266
View directory record Official record
Conditions
Peripheral Neuropathy, Diabetes Mellitus, Diabetes Complications
Interventions
Thiamine
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Not applicable Interventional

A Nutritional Intervention for Diabetic Neuropathy (WCCR-DN2)

NCT01953757
View directory record Official record
Conditions
Diabetic Neuropathy
Interventions
Vegan diet and vitamin B12 supplement, Vitamin B12 supplement
Other · Dietary Supplement
Lead sponsor
Physicians Committee for Responsible Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 26, 2015 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 4 Interventional Results available

Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects

NCT02682901
View directory record Official record
Conditions
Diabetic Autonomic Neuropathy
Interventions
Cycloset, Placebo
Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
30 Years to 80 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2021 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 3 Interventional

Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)

NCT00594152
View directory record Official record
Conditions
Diabetic Nephropathy, Diabetic Retinopathy
Interventions
CIIIT
Drug
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 75 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 1995
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 14, 2008 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Not applicable Interventional

Evaluating the Effect of Diabetes Control Through Intensive Lifestyle Modifications on Diabetic Peripheral Neuropathy

NCT01565317
View directory record Official record
Conditions
Diabetic Polyneuropathy, Weight Loss
Interventions
Weight Achievement and Intensive Treatment (Why WAIT)
Other
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Gene Therapy for Painful Diabetic Neuropathy

NCT01002235
View directory record Official record
Conditions
Painful Diabetic Peripheral Neuropathy
Interventions
VM202
Biological
Lead sponsor
Helixmith Co., Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Walnut Creek, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 5, 2025 · Synced Jul 23, 2026, 7:06 AM EDT
Not listed Phase 3 Interventional

The Effects of the Magnetic Molecular Energizer (MME) on Diabetic Peripheral Neuropathy

NCT00134524
View directory record Official record
Conditions
Diabetic Neuropathies, Pain, Neuralgia
Interventions
MME procedure
Procedure
Lead sponsor
Advanced Magnetic Research Institute International
Industry
Eligibility
18 Years to 79 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
5
States / cities
Tucson, Arizona • Sterling Heights, Michigan • Mocksville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2007 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy

NCT01086150
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy
Interventions
Skin biopsy, Lidocaine 5% patches
Procedure · Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jun 10, 2020 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 1Phase 2 Interventional

Safety and Pharmacokinetics of CBX129801 in Patients With Type 1 Diabetes

NCT01293461
View directory record Official record
Conditions
Type 1 Diabetes, Diabetes Mellitus, Peripheral Diabetic Neuropathy
Interventions
CBX129801, Placebo
Drug
Lead sponsor
Cebix Incorporated
Industry
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
8
States / cities
Escondido, California • Tustin, California • Walnut Creek, California + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2013 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nociceptive Pain Fiber Response

NCT02696070
View directory record Official record
Conditions
Painful Peripheral Diabetic Neuropathy
Interventions
Provant Therapy System
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Jul 23, 2026, 7:06 AM EDT
Not listed Not applicable Interventional

The Nutritional Benefits of Metanx in Patients With Diabetic Peripheral Neuropathy (MEDIAN)

NCT01990092
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy, B Vitamin Deficiency
Interventions
Metanx, Placebo
Other
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
25 Years to 80 Years
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
25
States / cities
Mobile, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 21 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2016 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy

NCT00695565
View directory record Official record
Conditions
Painful Diabetic Neuropathy
Interventions
Placebo Gel, Clonidine Topical Gel (ARC-4558)
Drug
Lead sponsor
Arcion Therapeutics Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
16
States / cities
Birmingham, Alabama • Sacramento, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Jul 23, 2026, 7:06 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Safety and Efficacy of the Noxsano Wound Care Bandage

NCT04123093
View directory record Official record
Conditions
Wound Heal, Peripheral Artery Disease, Ulcer, Leg, Ulcer Foot, Diabetic Foot Ulcer, Arterial Insufficiency
Interventions
Noxsano Bandage (Healthy Volunteers), Noxsano Bandage (Wound Care)
Device
Lead sponsor
OhioHealth
Other
Eligibility
18 Years to 79 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 10, 2023 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 2 Interventional

Efficacy and Safety Study of TAK-128 in Treating Subjects With Diabetic Peripheral Neuropathy

NCT00229437
View directory record Official record
Conditions
Diabetic Neuropathies
Interventions
TAK-128, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years to 70 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
40
States / cities
Mesa, Arizona • Peoria, Arizona • Phoenix, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2012 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Not applicable Interventional

Treatment of Painful Diabetic Neuropathy With Photon Stimulation

NCT00539175
View directory record Official record
Conditions
Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy, Diabetic Mononeuropathy
Interventions
infrared light, infrared light; placebo
Device
Lead sponsor
East Bay Institute for Research and Education
Other
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Martinez, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2007 · Synced Jul 23, 2026, 7:06 AM EDT
Withdrawn Not applicable Interventional

The Effects of Passive Vibration in Patients With Diabetic Peripheral Neuropathy

NCT03415256
View directory record Official record
Conditions
Diabetic Neuropathies
Interventions
passive vibration, no passive vibration
Other
Lead sponsor
Loma Linda University
Other
Eligibility
40 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Jul 23, 2026, 7:06 AM EDT
Terminated Phase 3 Interventional Results available

A Placebo Controlled, Randomized, Double Blind Trial of Milnacipran for the Treatment of Idiopathic Neuropathy Pain

NCT01288937
View directory record Official record
Conditions
Idiopathic Peripheral Neuropathy
Interventions
Milnacipran, Placebo
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Balancing Treatment Outcomes and Medication Burden Among Patients With Symptomatic Diabetic Peripheral Neuropathy

NCT02056431
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy
Interventions
IVR Intervention Group
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 2Phase 3 Interventional Results available

A Follow-On Trial to Assess the Long Term Safety and Efficacy of SPM 927 in Painful Distal Diabetic Neuropathy

NCT00235443
View directory record Official record
Conditions
Diabetic Neuropathy
Interventions
lacosamide
Drug
Lead sponsor
UCB Pharma
Industry
Eligibility
32 Years to 81 Years
Enrollment
451 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
84
States / cities
Anniston, Alabama • Hoover, Alabama • Huntsville, Alabama + 81 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Jul 23, 2026, 7:06 AM EDT
Completed Phase 4 Interventional

Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

NCT00159731
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy
Interventions
Pregabalin
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
29
States / cities
Hot Springs, Arkansas • La Jolla, California • Torrance, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Jul 23, 2026, 7:06 AM EDT
Terminated Phase 1Phase 2 Interventional

Nicotinamide Riboside for Diabetic Neuropathy

NCT03685253
View directory record Official record
Conditions
Diabetic Neuropathy Peripheral
Interventions
Niagen, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
30 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Jul 23, 2026, 7:06 AM EDT